The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures

	The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures
	Zhang, Dandan; Ding, Haiyan; Liu, Lili; Hou, Xinlin; Sun, Guoyu; Li, Lei; Liu, Yunzhe; Zhou, Congle; Gu, Ruolei; Luo, Yuejia; Hou, XL (reprint author), Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China.
心理所单位排序	5
摘要	Neonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG measurement and subsequent neurologic outcome are scarce. In this study, the prognostic value of aEEG features was systematically analyzed in 143 full-term neonates to identify prognostic indicators of neurodevelopmental outcome. Neonatal aEEG features of background pattern, cyclicity, and seizure activity, as well as the etiology of neonatal seizures, were significantly associated with neurodevelopmental outcome at one year of age. aEEG background pattern was highly associated with neurologic outcomes (chi(2) = 116.9), followed by aEEG cyclicity (chi(2) = 87.2) and seizure etiology (chi(2) = 79.3). Multiple linear regression showed that the four predictors explained 71.2% of the variation in neurological outcome, with standardized beta coefficients of 0.44, 0.24, 0.22, and 0.14 for the predictors of aEEG background pattern, cyclicity, etiology, and aEEG seizure activity, respectively. This clinically applicable scoring system based on etiology and three aEEG indices would allow pediatricians to assess the risk for neurodevelopmental impairment and facilitate an early intervention in newborns developing seizures.
学科领域	Developmental Psychology ,Physiological Psychology/biological Psychology
	2013
语种	英语
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	8 期号:11
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was funded by the National Natural Science Foundation of China (31300867; 31300847; 91132704). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS关键词	HYPOXIC-ISCHEMIC ENCEPHALOPATHY ; PREDICTIVE-VALUE ; PRETERM INFANTS ; NEUROLOGIC EXAMINATION ; BIRTH ASPHYXIA ; ELECTROENCEPHALOGRAPHY ; AEEG ; HYPOTHERMIA ; NEWBORN ; BORN
WOS标题词	Science & Technology
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000327254700073
资助机构	National Natural Science Foundation of China [31300867, 31300847, 91132704]
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10743
专题	中国科学院行为科学重点实验室
通讯作者	Hou, XL (reprint author), Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China.
作者单位	Hou, XL (reprint author), Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, Dandan,Ding, Haiyan,Liu, Lili,et al. The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures[J]. PLOS ONE,2013,8(11).
APA	Zhang, Dandan.,Ding, Haiyan.,Liu, Lili.,Hou, Xinlin.,Sun, Guoyu.,...&Hou, XL .(2013).The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures.PLOS ONE,8(11).
MLA	Zhang, Dandan,et al."The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures".PLOS ONE 8.11(2013).

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