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The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures
Zhang, Dandan; Ding, Haiyan; Liu, Lili; Hou, Xinlin; Sun, Guoyu; Li, Lei; Liu, Yunzhe; Zhou, Congle; Gu, Ruolei; Luo, Yuejia; Hou, XL (reprint author), Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China.
2013
Source PublicationPLOS ONE
ISSN1932-6203
Subtype期刊论文
Volume8Issue:11
Contribution Rank5
AbstractNeonatal seizures pose a high risk for adverse outcome in survived infants. While the prognostic value of amplitude-integrated electroencephalogram (aEEG) is well established in neonates with encephalopathy and asphyxia, neonatal seizure studies focusing on the direct correlation between early aEEG measurement and subsequent neurologic outcome are scarce. In this study, the prognostic value of aEEG features was systematically analyzed in 143 full-term neonates to identify prognostic indicators of neurodevelopmental outcome. Neonatal aEEG features of background pattern, cyclicity, and seizure activity, as well as the etiology of neonatal seizures, were significantly associated with neurodevelopmental outcome at one year of age. aEEG background pattern was highly associated with neurologic outcomes (chi(2) = 116.9), followed by aEEG cyclicity (chi(2) = 87.2) and seizure etiology (chi(2) = 79.3). Multiple linear regression showed that the four predictors explained 71.2% of the variation in neurological outcome, with standardized beta coefficients of 0.44, 0.24, 0.22, and 0.14 for the predictors of aEEG background pattern, cyclicity, etiology, and aEEG seizure activity, respectively. This clinically applicable scoring system based on etiology and three aEEG indices would allow pediatricians to assess the risk for neurodevelopmental impairment and facilitate an early intervention in newborns developing seizures.
Subject AreaDevelopmental Psychology ,Physiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [31300867, 31300847, 91132704]
Project Intro.This study was funded by the National Natural Science Foundation of China (31300867; 31300847; 91132704). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000327254700073
WOS HeadingsScience & Technology
WOS KeywordHYPOXIC-ISCHEMIC ENCEPHALOPATHY ; PREDICTIVE-VALUE ; PRETERM INFANTS ; NEUROLOGIC EXAMINATION ; BIRTH ASPHYXIA ; ELECTROENCEPHALOGRAPHY ; AEEG ; HYPOTHERMIA ; NEWBORN ; BORN
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Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10743
Collection中国科学院行为科学重点实验室
Corresponding AuthorHou, XL (reprint author), Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China.
AffiliationHou, XL (reprint author), Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China.
Recommended Citation
GB/T 7714
Zhang, Dandan,Ding, Haiyan,Liu, Lili,et al. The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures[J]. PLOS ONE,2013,8(11).
APA Zhang, Dandan.,Ding, Haiyan.,Liu, Lili.,Hou, Xinlin.,Sun, Guoyu.,...&Hou, XL .(2013).The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures.PLOS ONE,8(11).
MLA Zhang, Dandan,et al."The Prognostic Value of Amplitude-Integrated EEG in Full-Term Neonates with Seizures".PLOS ONE 8.11(2013).
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