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Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression
Ma, Zhenling1,2; Li, Rui1,3,4; Yu, Jing1,5; He, Yong6; Li, Juan1,3,4
2013-01-02
Source PublicationPLOS ONE
SubtypeArticle
Volume8Issue:1
AbstractThe early detection of major depression in elderly individuals who are at risk of developing the disease is of prime importance when it comes to the prevention of geriatric depression. We used resting-state functional magnetic resonance imaging (fMRI) to examine changes in regional homogeneity (ReHo) of spontaneous activity in late-life subthreshold depression (StD), and we evaluated the sensitivity/specificity performance of these changes. Nineteen elderly individuals with StD and 18 elderly controls underwent a resting-state fMRI scan. The ReHo approach was employed to examine whether StD was related to alterations in resting-state neural activity, in the form of abnormal regional synchronization. Receiver operating characteristic curve analysis and the Fisher stepwise discriminant analysis were used to evaluate the sensitivity/specificity characteristics of the ReHo index in discriminating between the StD subjects and normal controls. The results demonstrated that, compared to controls, StD subjects display lower ReHo in the right orbitofrontal cortex (OFC), left dorsolateral prefrontal cortex (DLPFC), left postcentral gyrus (PCG), and left middle frontal and inferior temporal gyri, as well as higher ReHo in the bilateral insula and right DLPFC. The left PCG and the right DLPFC, OFC, and posterior insula, together reported a predictive accuracy of 91.9%. These results suggest that the regional activity coherence was changed in the resting brain of StD subjects, and that these alterations may serve as potential markers for the early detection of StD in late-life depression.
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000313320900065
WOS HeadingsScience & Technology
WOS KeywordSTATE FUNCTIONAL CONNECTIVITY ; VOXEL-BASED MORPHOMETRY ; MAJOR DEPRESSION ; BIPOLAR DISORDER ; PARKINSONS-DISEASE ; FRONTAL-LOBE ; ABNORMALITIES ; FMRI ; CORTEX ; ASYMMETRY
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10748
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Union Med Coll, Sch Nursing, Beijing 100021, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
4.Beijing Normal Univ, Res Ctr Emot Regulat, Beijing 100875, Peoples R China
5.Southwest Univ, Sch Psychol, Chongqing, Peoples R China
6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
Recommended Citation
GB/T 7714
Ma, Zhenling,Li, Rui,Yu, Jing,et al. Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression[J]. PLOS ONE,2013,8(1).
APA Ma, Zhenling,Li, Rui,Yu, Jing,He, Yong,&Li, Juan.(2013).Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression.PLOS ONE,8(1).
MLA Ma, Zhenling,et al."Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression".PLOS ONE 8.1(2013).
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