PSYCH OpenIR  > 中国科学院心理健康重点实验室
Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression
Ma, Zhenling1,2; Li, Rui1,3,4; Yu, Jing1,5; He, Yong6; Li, Juan1,3,4
2013-01-02
发表期刊PLOS ONE
文章类型Article
卷号8期号:1
摘要The early detection of major depression in elderly individuals who are at risk of developing the disease is of prime importance when it comes to the prevention of geriatric depression. We used resting-state functional magnetic resonance imaging (fMRI) to examine changes in regional homogeneity (ReHo) of spontaneous activity in late-life subthreshold depression (StD), and we evaluated the sensitivity/specificity performance of these changes. Nineteen elderly individuals with StD and 18 elderly controls underwent a resting-state fMRI scan. The ReHo approach was employed to examine whether StD was related to alterations in resting-state neural activity, in the form of abnormal regional synchronization. Receiver operating characteristic curve analysis and the Fisher stepwise discriminant analysis were used to evaluate the sensitivity/specificity characteristics of the ReHo index in discriminating between the StD subjects and normal controls. The results demonstrated that, compared to controls, StD subjects display lower ReHo in the right orbitofrontal cortex (OFC), left dorsolateral prefrontal cortex (DLPFC), left postcentral gyrus (PCG), and left middle frontal and inferior temporal gyri, as well as higher ReHo in the bilateral insula and right DLPFC. The left PCG and the right DLPFC, OFC, and posterior insula, together reported a predictive accuracy of 91.9%. These results suggest that the regional activity coherence was changed in the resting brain of StD subjects, and that these alterations may serve as potential markers for the early detection of StD in late-life depression.
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000313320900065
WOS标题词Science & Technology
关键词[WOS]STATE FUNCTIONAL CONNECTIVITY ; VOXEL-BASED MORPHOMETRY ; MAJOR DEPRESSION ; BIPOLAR DISORDER ; PARKINSONS-DISEASE ; FRONTAL-LOBE ; ABNORMALITIES ; FMRI ; CORTEX ; ASYMMETRY
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10748
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Peking Union Med Coll, Sch Nursing, Beijing 100021, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
4.Beijing Normal Univ, Res Ctr Emot Regulat, Beijing 100875, Peoples R China
5.Southwest Univ, Sch Psychol, Chongqing, Peoples R China
6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714
Ma, Zhenling,Li, Rui,Yu, Jing,et al. Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression[J]. PLOS ONE,2013,8(1).
APA Ma, Zhenling,Li, Rui,Yu, Jing,He, Yong,&Li, Juan.(2013).Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression.PLOS ONE,8(1).
MLA Ma, Zhenling,et al."Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression".PLOS ONE 8.1(2013).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000313320900065.p(2688KB)期刊论文出版稿限制开放Apache License浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ma, Zhenling]的文章
[Li, Rui]的文章
[Yu, Jing]的文章
百度学术
百度学术中相似的文章
[Ma, Zhenling]的文章
[Li, Rui]的文章
[Yu, Jing]的文章
必应学术
必应学术中相似的文章
[Ma, Zhenling]的文章
[Li, Rui]的文章
[Yu, Jing]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000313320900065.pdf.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。