Institutional Repository of Key Laboratory of Mental Health, CAS
| Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression | |
Ma, Zhenling1,2 ; Li, Rui1,3,4; Yu, Jing1,5; He, Yong6; Li, Juan1,3,4
| |
| 摘要 | The early detection of major depression in elderly individuals who are at risk of developing the disease is of prime importance when it comes to the prevention of geriatric depression. We used resting-state functional magnetic resonance imaging (fMRI) to examine changes in regional homogeneity (ReHo) of spontaneous activity in late-life subthreshold depression (StD), and we evaluated the sensitivity/specificity performance of these changes. Nineteen elderly individuals with StD and 18 elderly controls underwent a resting-state fMRI scan. The ReHo approach was employed to examine whether StD was related to alterations in resting-state neural activity, in the form of abnormal regional synchronization. Receiver operating characteristic curve analysis and the Fisher stepwise discriminant analysis were used to evaluate the sensitivity/specificity characteristics of the ReHo index in discriminating between the StD subjects and normal controls. The results demonstrated that, compared to controls, StD subjects display lower ReHo in the right orbitofrontal cortex (OFC), left dorsolateral prefrontal cortex (DLPFC), left postcentral gyrus (PCG), and left middle frontal and inferior temporal gyri, as well as higher ReHo in the bilateral insula and right DLPFC. The left PCG and the right DLPFC, OFC, and posterior insula, together reported a predictive accuracy of 91.9%. These results suggest that the regional activity coherence was changed in the resting brain of StD subjects, and that these alterations may serve as potential markers for the early detection of StD in late-life depression. |
| 2013-01-02 | |
| 语种 | 英语 |
| 发表期刊 | PLOS ONE
 |
| 卷号 | 8期号:1 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS关键词 | STATE FUNCTIONAL CONNECTIVITY ; VOXEL-BASED MORPHOMETRY ; MAJOR DEPRESSION ; BIPOLAR DISORDER ; PARKINSONS-DISEASE ; FRONTAL-LOBE ; ABNORMALITIES ; FMRI ; CORTEX ; ASYMMETRY |
| WOS标题词 | Science & Technology |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000313320900065 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/10748 |
| 专题 | 中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 2.Peking Union Med Coll, Sch Nursing, Beijing 100021, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 4.Beijing Normal Univ, Res Ctr Emot Regulat, Beijing 100875, Peoples R China 5.Southwest Univ, Sch Psychol, Chongqing, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Zhenling,Li, Rui,Yu, Jing,et al. Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression[J]. PLOS ONE,2013,8(1). |
| APA | Ma, Zhenling,Li, Rui,Yu, Jing,He, Yong,&Li, Juan.(2013).Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression.PLOS ONE,8(1). |
| MLA | Ma, Zhenling,et al."Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression".PLOS ONE 8.1(2013). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000313320900065.p（2688KB） | 期刊论文 | 出版稿 | 开放获取 | Apache License | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论