Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra

	Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra
	Ruan, Yeping 1; Yao, Li 1; Zhang, Bingbing 1; Zhang, Shuijuan 1; Guo, Jianyou2 ; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
心理所单位排序	2
摘要	Background: Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the alpha- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on the anti-inflammatory effects of NT. Therefore, the anti-inflammatory activity of Neurotoxin-Nna was investigated in this study. Methods: The anti-inflammatory effects of NT were evaluated by measuring its influence on several crucial factors in inflammatory pathways, including total antioxidant activity, antinociceptive effects in vivo, nuclear factor kappa B (NF-kappa B), polymorphonuclear cells (PMN), inducible nitric oxide synthase (iNOS), adhesion molecule (ICAM-1) and tactile hyperalgesia. Results: NT treatment decreased the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta). NT treatment decreased the total antioxidant status (TAOS) and reduced CFA-induced tactile hyperalgesia in a dose-dependent manner. NT significantly inhibited regulation of NF-kappaB activation and the production of IL-1 beta, TNF-.alpha;, iNOS and CAM-1. Moreover, NT suppressed infiltration of PMN. Conclusions: Our results showed that NT reduced CFA-induced tactile hyperalgesia through inhibition inflammatory pathways in experimental inflammatory rats.
关键词	Neurotoxin-Nna Anti-inflammatory Antinociceptive Tumor necrosis factor alpha Interleukin 1 beta Nuclear factor kappa B
学科领域	Medical Psychology
	2013
语种	英语
发表期刊	BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1472-6882
卷号	13
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This project was supported by NNSF grant (30800301, 31170992, 81102842) and Nature Sciences Foundation of Zhejiang (Y2101127), projects from Key Laboratory of Mental Health, Institute of Psychology and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS关键词	NITRIC-OXIDE ; INFLAMMATION ; RATS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Integrative & Complementary Medicine
WOS类目	Integrative & Complementary Medicine
WOS记录号	WOS:000320255300001
资助机构	NNSF [30800301, 31170992, 81102842] ; Nature Sciences Foundation of Zhejiang [Y2101127] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10750
专题	中国科学院心理健康重点实验室
通讯作者	Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
作者单位	1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,13.
APA	Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2013).Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA	Ruan, Yeping,et al."Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 13(2013).

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