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Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra
Ruan, Yeping1; Yao, Li1; Zhang, Bingbing1; Zhang, Shuijuan1; Guo, Jianyou2; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
2013
Source PublicationBMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1472-6882
Subtype期刊论文
Volume13
Contribution Rank2
AbstractBackground: Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the alpha- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on the anti-inflammatory effects of NT. Therefore, the anti-inflammatory activity of Neurotoxin-Nna was investigated in this study. Methods: The anti-inflammatory effects of NT were evaluated by measuring its influence on several crucial factors in inflammatory pathways, including total antioxidant activity, antinociceptive effects in vivo, nuclear factor kappa B (NF-kappa B), polymorphonuclear cells (PMN), inducible nitric oxide synthase (iNOS), adhesion molecule (ICAM-1) and tactile hyperalgesia. Results: NT treatment decreased the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta). NT treatment decreased the total antioxidant status (TAOS) and reduced CFA-induced tactile hyperalgesia in a dose-dependent manner. NT significantly inhibited regulation of NF-kappaB activation and the production of IL-1 beta, TNF-.alpha;, iNOS and CAM-1. Moreover, NT suppressed infiltration of PMN. Conclusions: Our results showed that NT reduced CFA-induced tactile hyperalgesia through inhibition inflammatory pathways in experimental inflammatory rats.
KeywordNeurotoxin-Nna Anti-inflammatory Antinociceptive Tumor necrosis factor alpha Interleukin 1 beta Nuclear factor kappa B
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNNSF [30800301, 31170992, 81102842] ; Nature Sciences Foundation of Zhejiang [Y2101127] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
Project Intro.This project was supported by NNSF grant (30800301, 31170992, 81102842) and Nature Sciences Foundation of Zhejiang (Y2101127), projects from Key Laboratory of Mental Health, Institute of Psychology and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000320255300001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNITRIC-OXIDE ; INFLAMMATION ; RATS
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Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10750
Collection中国科学院心理健康重点实验室
Corresponding AuthorRuan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
Affiliation1.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013,13.
APA Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2013).Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,13.
MLA Ruan, Yeping,et al."Anti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 13(2013).
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