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Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats
Luo, Jia1,2; Wang, Tao1; Liang, Shan1,2; Hu, Xu1; Li, Wei1,2; Jin, Feng1; Jin, F (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2013
Source PublicationBEHAVIORAL AND BRAIN FUNCTIONS
ISSN1744-9081
Subtype期刊论文
Volume9
Contribution Rank1
AbstractHuman and animals studies support the idea that there is a gender-related co-morbidity of pain-related and inflammatory gastrointestinal (GI) diseases with psychological disorders. This co-morbidity is the evidence for the existence of GI-brain axis which consists of immune (cytokines), neural (vagus nerve) and neuroendocrine (HPA axis) pathways. Psychological stress causes disturbances in GI physiology, such as altered GI barrier function, changes in motility and secretion, development of visceral hypersensitivity, and dysfunction of inflammatory responses. Whether GI inflammation would exert impact on psychological behavior is not well established. We examined the effect of experimental gastritis on anxiety-and depression-like behaviors in male and female Sprague-Dawley rats, and evaluated potential mechanisms of action. Gastritis was induced by adding 0.1% (w/v) iodoacetamide (IAA) to the sterile drinking water for 7 days. Sucrose preference test assessed the depression-like behavior, open field test and elevated plus maze evaluated the anxiety-like behavior. IAA treatment induced gastric inflammation in rats of either gender. No behavioral abnormality or dysfunction of GI-brain axis was observed in male rats with IAA-induced gastritis. Anxiety- and depression-like behaviors were apparent and the HPA axis was hyperactive in female rats with IAA-induced gastritis. Our results show that gastric inflammation leads to anxiety- and depression-like behaviors in female but not male rats via the neuroendocrine (HPA axis) pathway, suggesting that the GI inflammation can impair normal brain function and induce changes in psychological behavior in a gender-related manner through the GI-to-brain signaling.
KeywordGastrointestinal-brain axis Iodoacetamide-induced gastritis Anxiety Depression Gender difference
Subject AreaEmotional Psychology
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Indexed BySCI
Language英语
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000329909500001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordFOS MESSENGER-RNA ; IRRITABLE-BOWEL-SYNDROME ; REPEATED RESTRAINT STRESS ; ESTROGEN-RECEPTOR-ALPHA ; PITUITARY-ADRENAL AXIS ; EARLY GENE-EXPRESSION ; C-FOS ; PARAVENTRICULAR NUCLEUS ; GENDER-DIFFERENCES ; CITROBACTER-RODENTIUM
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10752
Collection脑与认知科学国家重点实验室
Corresponding AuthorJin, F (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Luo, Jia,Wang, Tao,Liang, Shan,et al. Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2013,9.
APA Luo, Jia.,Wang, Tao.,Liang, Shan.,Hu, Xu.,Li, Wei.,...&Jin, F .(2013).Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats.BEHAVIORAL AND BRAIN FUNCTIONS,9.
MLA Luo, Jia,et al."Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats".BEHAVIORAL AND BRAIN FUNCTIONS 9(2013).
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