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Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats
Luo, Jia1,2; Wang, Tao1; Liang, Shan1,2; Hu, Xu1; Li, Wei1,2; Jin, Feng1; Jin, F (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2013
发表期刊BEHAVIORAL AND BRAIN FUNCTIONS
ISSN1744-9081
文章类型期刊论文
卷号9
产权排序1
摘要Human and animals studies support the idea that there is a gender-related co-morbidity of pain-related and inflammatory gastrointestinal (GI) diseases with psychological disorders. This co-morbidity is the evidence for the existence of GI-brain axis which consists of immune (cytokines), neural (vagus nerve) and neuroendocrine (HPA axis) pathways. Psychological stress causes disturbances in GI physiology, such as altered GI barrier function, changes in motility and secretion, development of visceral hypersensitivity, and dysfunction of inflammatory responses. Whether GI inflammation would exert impact on psychological behavior is not well established. We examined the effect of experimental gastritis on anxiety-and depression-like behaviors in male and female Sprague-Dawley rats, and evaluated potential mechanisms of action. Gastritis was induced by adding 0.1% (w/v) iodoacetamide (IAA) to the sterile drinking water for 7 days. Sucrose preference test assessed the depression-like behavior, open field test and elevated plus maze evaluated the anxiety-like behavior. IAA treatment induced gastric inflammation in rats of either gender. No behavioral abnormality or dysfunction of GI-brain axis was observed in male rats with IAA-induced gastritis. Anxiety- and depression-like behaviors were apparent and the HPA axis was hyperactive in female rats with IAA-induced gastritis. Our results show that gastric inflammation leads to anxiety- and depression-like behaviors in female but not male rats via the neuroendocrine (HPA axis) pathway, suggesting that the GI inflammation can impair normal brain function and induce changes in psychological behavior in a gender-related manner through the GI-to-brain signaling.
关键词Gastrointestinal-brain axis Iodoacetamide-induced gastritis Anxiety Depression Gender difference
学科领域Emotional Psychology
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收录类别SCI
语种英语
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000329909500001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FOS MESSENGER-RNA ; IRRITABLE-BOWEL-SYNDROME ; REPEATED RESTRAINT STRESS ; ESTROGEN-RECEPTOR-ALPHA ; PITUITARY-ADRENAL AXIS ; EARLY GENE-EXPRESSION ; C-FOS ; PARAVENTRICULAR NUCLEUS ; GENDER-DIFFERENCES ; CITROBACTER-RODENTIUM
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被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10752
专题脑与认知科学国家重点实验室
通讯作者Jin, F (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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GB/T 7714
Luo, Jia,Wang, Tao,Liang, Shan,et al. Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2013,9.
APA Luo, Jia.,Wang, Tao.,Liang, Shan.,Hu, Xu.,Li, Wei.,...&Jin, F .(2013).Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats.BEHAVIORAL AND BRAIN FUNCTIONS,9.
MLA Luo, Jia,et al."Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats".BEHAVIORAL AND BRAIN FUNCTIONS 9(2013).
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