Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats

	Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats
	Luo, Jia1,2 ; Wang, Tao1 ; Liang, Shan1,2 ; Hu, Xu1 ; Li, Wei1,2 ; Jin, Feng1 ; Jin, F (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Human and animals studies support the idea that there is a gender-related co-morbidity of pain-related and inflammatory gastrointestinal (GI) diseases with psychological disorders. This co-morbidity is the evidence for the existence of GI-brain axis which consists of immune (cytokines), neural (vagus nerve) and neuroendocrine (HPA axis) pathways. Psychological stress causes disturbances in GI physiology, such as altered GI barrier function, changes in motility and secretion, development of visceral hypersensitivity, and dysfunction of inflammatory responses. Whether GI inflammation would exert impact on psychological behavior is not well established. We examined the effect of experimental gastritis on anxiety-and depression-like behaviors in male and female Sprague-Dawley rats, and evaluated potential mechanisms of action. Gastritis was induced by adding 0.1% (w/v) iodoacetamide (IAA) to the sterile drinking water for 7 days. Sucrose preference test assessed the depression-like behavior, open field test and elevated plus maze evaluated the anxiety-like behavior. IAA treatment induced gastric inflammation in rats of either gender. No behavioral abnormality or dysfunction of GI-brain axis was observed in male rats with IAA-induced gastritis. Anxiety- and depression-like behaviors were apparent and the HPA axis was hyperactive in female rats with IAA-induced gastritis. Our results show that gastric inflammation leads to anxiety- and depression-like behaviors in female but not male rats via the neuroendocrine (HPA axis) pathway, suggesting that the GI inflammation can impair normal brain function and induce changes in psychological behavior in a gender-related manner through the GI-to-brain signaling.
关键词	Gastrointestinal-brain axis Iodoacetamide-induced gastritis Anxiety Depression Gender difference
学科领域	Emotional Psychology
	2013
语种	英语
发表期刊	BEHAVIORAL AND BRAIN FUNCTIONS
ISSN	1744-9081
卷号	9
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
WOS关键词	FOS MESSENGER-RNA ; IRRITABLE-BOWEL-SYNDROME ; REPEATED RESTRAINT STRESS ; ESTROGEN-RECEPTOR-ALPHA ; PITUITARY-ADRENAL AXIS ; EARLY GENE-EXPRESSION ; C-FOS ; PARAVENTRICULAR NUCLEUS ; GENDER-DIFFERENCES ; CITROBACTER-RODENTIUM
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000329909500001
引用统计	被引频次：34[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10752
专题	脑与认知科学国家重点实验室
通讯作者	Jin, F (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Luo, Jia,Wang, Tao,Liang, Shan,et al. Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats[J]. BEHAVIORAL AND BRAIN FUNCTIONS,2013,9.
APA	Luo, Jia.,Wang, Tao.,Liang, Shan.,Hu, Xu.,Li, Wei.,...&Jin, F .(2013).Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats.BEHAVIORAL AND BRAIN FUNCTIONS,9.
MLA	Luo, Jia,et al."Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats".BEHAVIORAL AND BRAIN FUNCTIONS 9(2013).

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