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Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress
Lu, Jun1; Liang, Jia2; Wang, Jun-Ren3; Hu, Li1; Tu, Ya1; Guo, Jian-You4
2013
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
SubtypeArticle
AbstractExtracellular signal-regulated kinase (ERK)-cAMP response element binding protein (CREB) signal pathway has been implicated in the pathogenesis of depression. There is growing evidence that acupuncture in traditional Chinese medicine has antidepressant-like effect. However, the effect of acupuncture on ERK-CREB pathway remains unknown. In our study, the antidepressant-like effect of acupuncture treatment was measured by sucrose intake test and open field test in rats exposed to chronic unpredictable mild stress (CUMS) for 4 weeks. The protein levels of ERK1/2, CREB, phosphorylated ERK1/2 (p-ERK1/2), and phosphorylated CREB (p-CREB) in the hippocampus (HP) and prefrontal cortex (PFC) were examined by Western blot analysis. Our results showed that CUMS rats exhibited the reduction in behavioral activities, whereas acupuncture stimulation at acupoints Baihui (Du20) and Neiguan (PC6) reversed the behavioral deficit. In addition, exposure to CUMS resulted in the decrease of p-ERK1/2 and p-CREB in the HP and PFC. Acupuncture increased the ratio of p-ERK1/2 to ERK1/2 and the ratio of p-CREB to CREB in the HP and PFC. Our study suggested that one potential way, by which acupuncture had antidepressant-like effect, might be mediated by activating the ERK-CREB pathway in the brain.
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000321368200001
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEPRESSIVE-LIKE BEHAVIOR ; SIGNAL-REGULATED KINASE ; NEURONAL PLASTICITY ; PROTEIN EXPRESSION ; ANTIDEPRESSANT ; BRAIN ; HIPPOCAMPUS ; ANXIETY
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Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10763
Collection中国科学院心理健康重点实验室
Affiliation1.Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China
2.China Acad Chinese Med Sci, Grad Sch, Beijing 100700, Peoples R China
3.Beijing Heping Hosp Chaoyang Dist, Beijing 100103, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Lu, Jun,Liang, Jia,Wang, Jun-Ren,et al. Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Lu, Jun,Liang, Jia,Wang, Jun-Ren,Hu, Li,Tu, Ya,&Guo, Jian-You.(2013).Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Lu, Jun,et al."Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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