PSYCH OpenIR  > 中国科学院心理健康重点实验室
Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress
Lu, Jun1; Liang, Jia2; Wang, Jun-Ren3; Hu, Li1; Tu, Ya1; Guo, Jian-You4
2013
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
文章类型Article
摘要Extracellular signal-regulated kinase (ERK)-cAMP response element binding protein (CREB) signal pathway has been implicated in the pathogenesis of depression. There is growing evidence that acupuncture in traditional Chinese medicine has antidepressant-like effect. However, the effect of acupuncture on ERK-CREB pathway remains unknown. In our study, the antidepressant-like effect of acupuncture treatment was measured by sucrose intake test and open field test in rats exposed to chronic unpredictable mild stress (CUMS) for 4 weeks. The protein levels of ERK1/2, CREB, phosphorylated ERK1/2 (p-ERK1/2), and phosphorylated CREB (p-CREB) in the hippocampus (HP) and prefrontal cortex (PFC) were examined by Western blot analysis. Our results showed that CUMS rats exhibited the reduction in behavioral activities, whereas acupuncture stimulation at acupoints Baihui (Du20) and Neiguan (PC6) reversed the behavioral deficit. In addition, exposure to CUMS resulted in the decrease of p-ERK1/2 and p-CREB in the HP and PFC. Acupuncture increased the ratio of p-ERK1/2 to ERK1/2 and the ratio of p-CREB to CREB in the HP and PFC. Our study suggested that one potential way, by which acupuncture had antidepressant-like effect, might be mediated by activating the ERK-CREB pathway in the brain.
收录类别SCI
语种英语
WOS研究方向Integrative & Complementary Medicine
WOS类目Integrative & Complementary Medicine
WOS记录号WOS:000321368200001
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DEPRESSIVE-LIKE BEHAVIOR ; SIGNAL-REGULATED KINASE ; NEURONAL PLASTICITY ; PROTEIN EXPRESSION ; ANTIDEPRESSANT ; BRAIN ; HIPPOCAMPUS ; ANXIETY
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10763
专题中国科学院心理健康重点实验室
作者单位1.Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China
2.China Acad Chinese Med Sci, Grad Sch, Beijing 100700, Peoples R China
3.Beijing Heping Hosp Chaoyang Dist, Beijing 100103, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Lu, Jun,Liang, Jia,Wang, Jun-Ren,et al. Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Lu, Jun,Liang, Jia,Wang, Jun-Ren,Hu, Li,Tu, Ya,&Guo, Jian-You.(2013).Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Lu, Jun,et al."Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000321368200001.p(2029KB)期刊论文出版稿限制开放Apache License浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lu, Jun]的文章
[Liang, Jia]的文章
[Wang, Jun-Ren]的文章
百度学术
百度学术中相似的文章
[Lu, Jun]的文章
[Liang, Jia]的文章
[Wang, Jun-Ren]的文章
必应学术
必应学术中相似的文章
[Lu, Jun]的文章
[Liang, Jia]的文章
[Wang, Jun-Ren]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000321368200001.pdf.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。