Institutional Repository of Key Laboratory of Mental Health, CAS
Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress | |
Lu, Jun1; Liang, Jia2; Wang, Jun-Ren3; Hu, Li1; Tu, Ya1; Guo, Jian-You4 | |
摘要 | Extracellular signal-regulated kinase (ERK)-cAMP response element binding protein (CREB) signal pathway has been implicated in the pathogenesis of depression. There is growing evidence that acupuncture in traditional Chinese medicine has antidepressant-like effect. However, the effect of acupuncture on ERK-CREB pathway remains unknown. In our study, the antidepressant-like effect of acupuncture treatment was measured by sucrose intake test and open field test in rats exposed to chronic unpredictable mild stress (CUMS) for 4 weeks. The protein levels of ERK1/2, CREB, phosphorylated ERK1/2 (p-ERK1/2), and phosphorylated CREB (p-CREB) in the hippocampus (HP) and prefrontal cortex (PFC) were examined by Western blot analysis. Our results showed that CUMS rats exhibited the reduction in behavioral activities, whereas acupuncture stimulation at acupoints Baihui (Du20) and Neiguan (PC6) reversed the behavioral deficit. In addition, exposure to CUMS resulted in the decrease of p-ERK1/2 and p-CREB in the HP and PFC. Acupuncture increased the ratio of p-ERK1/2 to ERK1/2 and the ratio of p-CREB to CREB in the HP and PFC. Our study suggested that one potential way, by which acupuncture had antidepressant-like effect, might be mediated by activating the ERK-CREB pathway in the brain. |
2013 | |
语种 | 英语 |
发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
期刊论文类型 | Article |
收录类别 | SCI |
WOS关键词 | DEPRESSIVE-LIKE BEHAVIOR ; SIGNAL-REGULATED KINASE ; NEURONAL PLASTICITY ; PROTEIN EXPRESSION ; ANTIDEPRESSANT ; BRAIN ; HIPPOCAMPUS ; ANXIETY |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Integrative & Complementary Medicine |
WOS类目 | Integrative & Complementary Medicine |
WOS记录号 | WOS:000321368200001 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/10763 |
专题 | 中国科学院心理健康重点实验室 |
作者单位 | 1.Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China 2.China Acad Chinese Med Sci, Grad Sch, Beijing 100700, Peoples R China 3.Beijing Heping Hosp Chaoyang Dist, Beijing 100103, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Lu, Jun,Liang, Jia,Wang, Jun-Ren,et al. Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013. |
APA | Lu, Jun,Liang, Jia,Wang, Jun-Ren,Hu, Li,Tu, Ya,&Guo, Jian-You.(2013).Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. |
MLA | Lu, Jun,et al."Acupuncture Activates ERK-CREB Pathway in Rats Exposed to Chronic Unpredictable Mild Stress".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013). |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
WOS000321368200001.p(2029KB) | 期刊论文 | 出版稿 | 限制开放 | Apache License | 请求全文 |
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