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Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells
Chen, Tianpeng1,2; Hao, Jianxiong3; He, Jinfeng2; Zhang, Jianchun2; Li, Yingcong4; Liu, Rui5; Li, Lite5; Li, LT (reprint author), China Agr Univ, Post Box 40,17 Qinghua Donglu, Beijing 100083, Peoples R China.
2013
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Subtype期刊论文
Volume138Issue:2014-02-03Pages:1034-1041
Contribution Rank4
AbstractThis study investigates the anticancer properties of cannabisin B, purified from hempseed hull, in HepG2 human hepatoblastoma cells. The results indicate that cannabisin B significantly inhibited cell proliferation by inducing autophagic cell death rather than typical apoptosis. Cell viability transiently increased upon the addition of a low concentration of cannabisin B but decreased upon the addition of high concentrations. Cannabisin B-induced changes in cell viability were completely inhibited by pre-treatment with 3-methyladenine (3-MA), indicating that the induction of autophagy by cannabisin B caused cell death. Additionally, cannabisin B induced S phase cell cycle arrest in a dose-dependent manner. Moreover, cannabisin B was found to inhibit survival signaling by blocking the activation of AKT and down-stream targets of the mammalian target of rapamycin (mTOR). These findings suggest that cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. (C) 2012 Elsevier Ltd. All rights reserved.
KeywordCannabisin B Antiproliferative Autophagy AKT mTOR Cell cycle arrest
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000316039500044
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
WOS KeywordANTIPROLIFERATIVE ACTIVITIES ; CANCER CELLS ; ANTIOXIDANT ; APOPTOSIS ; PHYTOCHEMICALS ; HEPATOBLASTOMA ; INDUCTION ; SATIVA ; PEELS ; L.
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10772
Collection支撑系统
Corresponding AuthorLi, LT (reprint author), China Agr Univ, Post Box 40,17 Qinghua Donglu, Beijing 100083, Peoples R China.
Affiliation1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Res Ctr China Hemp Mat, Quartermaster Res Inst, Gen Logist Dept, Beijing 100082, Peoples R China
3.Hebei Univ Sci & Technol, Shijiazhuang 050054, Hebei, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100083, Peoples R China
5.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Chen, Tianpeng,Hao, Jianxiong,He, Jinfeng,et al. Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells[J]. FOOD CHEMISTRY,2013,138(2014-02-03):1034-1041.
APA Chen, Tianpeng.,Hao, Jianxiong.,He, Jinfeng.,Zhang, Jianchun.,Li, Yingcong.,...&Li, LT .(2013).Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells.FOOD CHEMISTRY,138(2014-02-03),1034-1041.
MLA Chen, Tianpeng,et al."Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells".FOOD CHEMISTRY 138.2014-02-03(2013):1034-1041.
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