| Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells | |
Chen, Tianpeng1,2; Hao, Jianxiong3; He, Jinfeng2; Zhang, Jianchun2; Li, Yingcong4 ; Liu, Rui5; Li, Lite5; Li, LT (reprint author), China Agr Univ, Post Box 40,17 Qinghua Donglu, Beijing 100083, Peoples R China.
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| 心理所单位排序 | 4 |
| 摘要 | This study investigates the anticancer properties of cannabisin B, purified from hempseed hull, in HepG2 human hepatoblastoma cells. The results indicate that cannabisin B significantly inhibited cell proliferation by inducing autophagic cell death rather than typical apoptosis. Cell viability transiently increased upon the addition of a low concentration of cannabisin B but decreased upon the addition of high concentrations. Cannabisin B-induced changes in cell viability were completely inhibited by pre-treatment with 3-methyladenine (3-MA), indicating that the induction of autophagy by cannabisin B caused cell death. Additionally, cannabisin B induced S phase cell cycle arrest in a dose-dependent manner. Moreover, cannabisin B was found to inhibit survival signaling by blocking the activation of AKT and down-stream targets of the mammalian target of rapamycin (mTOR). These findings suggest that cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. (C) 2012 Elsevier Ltd. All rights reserved. |
| 关键词 | Cannabisin B Antiproliferative Autophagy AKT mTOR Cell cycle arrest |
| 学科领域 | Medical Psychology |
| 2013 | |
| 语种 | 英语 |
| 发表期刊 | FOOD CHEMISTRY
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| ISSN | 0308-8146 |
| 卷号 | 138期号:2014-02-03页码:1034-1041 |
| 期刊论文类型 | 期刊论文 |
| URL | 查看原文 |
| 收录类别 | SCI |
| WOS关键词 | ANTIPROLIFERATIVE ACTIVITIES ; CANCER CELLS ; ANTIOXIDANT ; APOPTOSIS ; PHYTOCHEMICALS ; HEPATOBLASTOMA ; INDUCTION ; SATIVA ; PEELS ; L. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine |
| WOS研究方向 | Chemistry ; Food Science & Technology ; Nutrition & Dietetics |
| WOS类目 | Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics |
| WOS记录号 | WOS:000316039500044 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/10772 |
| 专题 | 管理支撑系统 |
| 通讯作者 | Li, LT (reprint author), China Agr Univ, Post Box 40,17 Qinghua Donglu, Beijing 100083, Peoples R China. |
| 作者单位 | 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 2.Res Ctr China Hemp Mat, Quartermaster Res Inst, Gen Logist Dept, Beijing 100082, Peoples R China 3.Hebei Univ Sci & Technol, Shijiazhuang 050054, Hebei, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100083, Peoples R China 5.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Tianpeng,Hao, Jianxiong,He, Jinfeng,et al. Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells[J]. FOOD CHEMISTRY,2013,138(2014-02-03):1034-1041. |
| APA | Chen, Tianpeng.,Hao, Jianxiong.,He, Jinfeng.,Zhang, Jianchun.,Li, Yingcong.,...&Li, LT .(2013).Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells.FOOD CHEMISTRY,138(2014-02-03),1034-1041. |
| MLA | Chen, Tianpeng,et al."Cannabisin B induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arrest in HepG2 cells".FOOD CHEMISTRY 138.2014-02-03(2013):1034-1041. |
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