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Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder
Di Martino, Adriana; Zuo, Xi-Nian; Kelly, Clare; Grzadzinski, Rebecca; Mennes, Maarten; Schvarcz, Ariel; Rodman, Jennifer; Lord, Catherine; Castellanos, F. Xavier; Milham, Michael P.; Milham, MP (reprint author), Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA.
2013
发表期刊BIOLOGICAL PSYCHIATRY
ISSN0006-3223
文章类型期刊论文
卷号74期号:8页码:623-632
产权排序2
摘要Background: Individuals with autism spectrum disorders (ASD) often exhibit symptoms of attention-deficit/hyperactivity disorder (ADHD). Across both disorders, observations of distributed functional abnormalities suggest aberrant large-scale brain network connectivity. Yet, common and distinct network correlates of ASD and ADHD remain unidentified. Here, we aimed to examine patterns of dysconnection in school-age children with ASD and ADHD and typically developing children who completed a resting state functional magnetic resonance imaging scan. Methods: We measured voxelwise network centrality, functional connectivity metrics indexing local (degree centrality [DC]) and global (eigenvector centrality) functional relationships across the entire brain connectome, in resting state functional magnetic resonance imaging data from 56 children with ASD, 45 children with ADHD, and 50 typically developing children. A one-way analysis of covariance, with group as fixed factor (whole-brain corrected), was followed by post hoc pairwise comparisons. Results: Cortical and subcortical areas exhibited centrality abnormalities, some common to both ADHD and ASD, such as in precuneus. Others were disorder-specific and included ADHD-related increases in DC in right striatum/pallidum, in contrast with ASD-related increases in bilateral temporolimbic areas. Secondary analyses differentiating children with ASD into those with or without ADHD-like comorbidity (ASD(+) and ASD(-), respectively) revealed that the ASD(+) group shared ADHD-specific abnormalities in basal ganglia. By contrast, centrality increases in temporolimbic areas characterized children with ASD regardless of ADHD-like comorbidity. At the cluster level, eigenvector centrality group patterns were similar to DC. Conclusions: ADHD and ASD are neurodevelopmental disorders with distinct and overlapping clinical presentations. This work provides evidence for both shared and distinct underlying mechanisms at the large-scale network level.
关键词ADHD amygdala autism caudate functional connectivity network centrality precuneus resting state fMRI
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者Brain & Behavior Research Foundation ; National Institute of Mental Health [K23MH087770, R01MH081218] ; National Institute of Child Health and Human Development [R01HD065282] ; Autism Speaks ; Stavros Niarchos Foundation ; Leon Levy Foundation ; Natural Science Foundation of China [81171409, 81220108014] ; Chinese Academy of Sciences [KSZD-EW-TZ-002, Y0CX492S03, Y2CX112006]
项目简介This work was supported by grants from the Brain & Behavior Research Foundation (previously known as National Alliance for Research in Schizophrenia and Affective Disorders) to ADM and National Institute of Mental Health (K23MH087770 to ADM; R01MH081218 to FXC); from the National Institute of Child Health and Human Development (R01HD065282), Autism Speaks, and the Stavros Niarchos Foundation, awarded to FXC; the Leon Levy Foundation awarded to MPM, ADM, and CK; the Natural Science Foundation of China (81171409, 81220108014) and the Chinese Academy of Sciences (KSZD-EW-TZ-002, Y0CX492S03, Y2CX112006) to X-NZ; and gifts from Joseph P. Healey and the Stavros Niarchos Foundation to the Child Mind Institute (MPM).
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Neurosciences ; Psychiatry
WOS记录号WOS:000324814900010
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]RESTING-STATE FMRI ; PERVASIVE DEVELOPMENTAL DISORDERS ; DEFICIT HYPERACTIVITY DISORDER ; DEFAULT-MODE NETWORK ; SPECTRUM DISORDERS ; CONNECTIVITY MRI ; HUMAN BRAIN ; PSYCHIATRIC-DISORDERS ; DIAGNOSTIC INTERVIEW ; YOUNG-CHILDREN
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被引频次:99[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10773
专题中国科学院行为科学重点实验室
通讯作者Milham, MP (reprint author), Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA.
作者单位Milham, MP (reprint author), Child Mind Inst, Ctr Developing Brain, 445 Pk Ave, New York, NY 10022 USA.
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Di Martino, Adriana,Zuo, Xi-Nian,Kelly, Clare,et al. Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder[J]. BIOLOGICAL PSYCHIATRY,2013,74(8):623-632.
APA Di Martino, Adriana.,Zuo, Xi-Nian.,Kelly, Clare.,Grzadzinski, Rebecca.,Mennes, Maarten.,...&Milham, MP .(2013).Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder.BIOLOGICAL PSYCHIATRY,74(8),623-632.
MLA Di Martino, Adriana,et al."Shared and Distinct Intrinsic Functional Network Centrality in Autism and Attention-Deficit/Hyperactivity Disorder".BIOLOGICAL PSYCHIATRY 74.8(2013):623-632.
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