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Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine
Ding, Xuekun1,2; Liang, Jing1; Zheng, Xigeng1; Bai, Yunjing1; Liu, Zhengkui1; Li, Yingying1,2; Xing, Xiaoli1,2; Liang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2013
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型期刊论文
卷号702页码:294-301
产权排序1
摘要Escalation of drug consumption is involved in the transition from drug use to addiction. Our previous study demonstrated that neuronal activation in ventral tegmental area (VTA) and substantia nigra (SN) was associated with behavioral sensitization induced by increasing doses of morphine. Here we sought to characterize the molecular mechanism underlying this behavioral sensitization. We compared mitogen-activated protein kinase (MAPK) signaling following pretreatment with either increasing doses or fixed doses of morphine before and after behavioral sensitization. We found phospho-MAPK markedly increased in ventral striatum and decreased in dorsal striatum after either pretreatment group, but no further change after sensitization induced by 10 mg/kg morphine challenge. Furthermore, we also evaluated the level of phospho-glutamate receptor 1 at serine 845 (pSer845-GluA1) and 831 (pSer831-GluA1) sites in ventral striatum and dorsal striatum. The results showed a significant increase in pSer845-GluA1/GluA1 ratio in ventral striatum but not dorsal striatum after pretreatment with increasing doses of morphine but not after fixed-dose or saline pretreatment. Importantly, pSer845-GluA1/GluA1 ratio was increased exclusively in dorsal striatum and not ventral striatum following acute morphine challenge specifically paired with increasing-dose pretreatment and not fixed-dose or saline. These findings indicate that behavioral sensitization-induced by chronic pretreatment with increasing doses of morphine might be more closely associated with the dynamic GluA1 activity in the striatum rather than the modulation of MAPK signaling. These findings also indicate that GluA1 phosphorylation may occur independent of MAPK activation. (C) 2013 Elsevier B.V. All rights reserved.
关键词Morphine Increasing doses GluA1 MAPK signaling Striatum
学科领域Physiological Psychology/biological Psychology,
收录类别SCI
语种英语
项目资助者Chinese Postdoctoral Fund [20090460047] ; Natural Scientific Foundation of China NSFC [31171080, 30970695] ; 973 Program [2010CB912303, 2012CB911004] ; QCAS Biotechnology Fund [GJHZ1131] ; Johnson & Johnson Corporate Office of Science Technology ; [CAS-KSCX2-YW-R-119] ; [KSCX2-YW-R-256] ; [QCAS GJHZ1131]
项目简介This work was supported by the National Foundation of Natural Science (30900400, 30971057 and 31271098) and the Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences.
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000317153100038
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]SIGNAL-TRANSDUCTION CASCADE ; SELF-ADMINISTERING MORPHINE ; AMPA RECEPTOR TRAFFICKING ; RAT NUCLEUS-ACCUMBENS ; BEHAVIORAL SENSITIZATION ; SYNAPTIC PLASTICITY ; SPINAL-CORD ; ENVIRONMENTAL CONTEXT ; REGULATED KINASE ; PROTEIN-KINASES
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10775
专题中国科学院心理健康重点实验室
通讯作者Liang, J (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Ding, Xuekun,Liang, Jing,Zheng, Xigeng,et al. Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2013,702:294-301.
APA Ding, Xuekun.,Liang, Jing.,Zheng, Xigeng.,Bai, Yunjing.,Liu, Zhengkui.,...&Liang, J .(2013).Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine.EUROPEAN JOURNAL OF PHARMACOLOGY,702,294-301.
MLA Ding, Xuekun,et al."Altered phosphorylation of GluA1 in the striatum is associated with locomotor sensitization induced by exposure to increasing doses of morphine".EUROPEAN JOURNAL OF PHARMACOLOGY 702(2013):294-301.
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