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Altered brain structure in Chinese dyslexic children
Liu, Li1; You, Wenping2; Wang, Wenjing1; Guo, Xiaojuan1,3; Peng, Danling1; Booth, James4; Liu, L (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
2013
Source PublicationNEUROPSYCHOLOGIA
ISSN0960-2011
Subtype期刊论文
Volume51Issue:7Pages:1169-1176
Contribution Rank2
AbstractDue to the logographic nature of the writing system, learning to read Chinese places heavy demands on encoding of orthographic forms through rote memorization. Moreover, phonology has to often be retrieved from memory during reading because of the inconsistent mapping between characters and their pronunciations. Using optimized voxel-based morphometry, we examined differences in volumetrics between children with reading disability (RD, 10-12 years old) and age-matched typically developing (TD) children. Our study shows reduced gray matter volume (GMV) for RD in right inferior occipital gyrus and left inferior frontal gyrus, consistent with previous studies suggesting that Chinese dyslexics have deficits in orthographic and phonological processing. The deficit in phonological processing was further supported by reductions in white matter volumes (WMV) in left precentral gyrus. Greater deficits in ortho-phonological processing may be associated with semantic compensation, as lower skill RD children showed greater GMV in anterior temporal cortex, even though as a group they showed less GMV in this region compared to TD. Perhaps most interestingly, we showed reduced GMV in bilateral ventromedial prefrontal cortices (vmPFC) and this was correlated with reductions in WMV within vmPFC, suggesting that RD have deficits in memory retrieval. Moreover, these GMV alterations in vmPFC for the RD were correlated with alterations in right parahippocampal gyrus, which also showed a reduced GMV, suggesting that RD have a correlated deficit in memory encoding. Our results ire consistent with previous studies suggesting that Chinese dyslexics have deficits in visuo-orthographic and phonological processing, but our study importantly suggests deficits in memory encoding and retrieval, perhaps due to the unique demands of the Chinese writing system. (C) 2013 Elsevier Ltd. All rights reserved.
KeywordChinese dyslexia Voxel-based morphometry Memory encoding and retrieval
Subject AreaCognitive Psychology,developmental Psychology
URL查看原文
Indexed BySSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [81030027, 30900362, 30971043] ; National Basic Research Program (973) [2007CB512305/2]
Project Intro.This study was supported by grants from Chinese National Natural Science Foundation (31000500, 81000603 and 81171016), the Fundamental Research Funds for the Central Universities, Beijing Natural Science Foundation (7102089) and the United States National Institute of Child Health and Human Development (HD042049).
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology, Experimental
WOS IDWOS:000321539400004
WOS HeadingsScience & Technology ; Social Sciences ; Life Sciences & Biomedicine
WOS KeywordINFERIOR PREFRONTAL CORTEX ; VOXEL-BASED MORPHOMETRY ; DEVELOPMENTAL DYSLEXIA ; GRAY-MATTER ; CONTEXTUAL FACILITATION ; DEFICIT HYPOTHESIS ; FUNCTIONAL-ANATOMY ; MEMORY ; LANGUAGE ; READERS
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10785
Collection中国科学院行为科学重点实验室
Corresponding AuthorLiu, L (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China
4.Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA
Recommended Citation
GB/T 7714
Liu, Li,You, Wenping,Wang, Wenjing,et al. Altered brain structure in Chinese dyslexic children[J]. NEUROPSYCHOLOGIA,2013,51(7):1169-1176.
APA Liu, Li.,You, Wenping.,Wang, Wenjing.,Guo, Xiaojuan.,Peng, Danling.,...&Liu, L .(2013).Altered brain structure in Chinese dyslexic children.NEUROPSYCHOLOGIA,51(7),1169-1176.
MLA Liu, Li,et al."Altered brain structure in Chinese dyslexic children".NEUROPSYCHOLOGIA 51.7(2013):1169-1176.
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