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Altered brain structure in Chinese dyslexic children
Liu, Li1; You, Wenping2; Wang, Wenjing1; Guo, Xiaojuan1,3; Peng, Danling1; Booth, James4; Liu, L (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
2013
发表期刊NEUROPSYCHOLOGIA
ISSN0960-2011
文章类型期刊论文
卷号51期号:7页码:1169-1176
产权排序2
摘要Due to the logographic nature of the writing system, learning to read Chinese places heavy demands on encoding of orthographic forms through rote memorization. Moreover, phonology has to often be retrieved from memory during reading because of the inconsistent mapping between characters and their pronunciations. Using optimized voxel-based morphometry, we examined differences in volumetrics between children with reading disability (RD, 10-12 years old) and age-matched typically developing (TD) children. Our study shows reduced gray matter volume (GMV) for RD in right inferior occipital gyrus and left inferior frontal gyrus, consistent with previous studies suggesting that Chinese dyslexics have deficits in orthographic and phonological processing. The deficit in phonological processing was further supported by reductions in white matter volumes (WMV) in left precentral gyrus. Greater deficits in ortho-phonological processing may be associated with semantic compensation, as lower skill RD children showed greater GMV in anterior temporal cortex, even though as a group they showed less GMV in this region compared to TD. Perhaps most interestingly, we showed reduced GMV in bilateral ventromedial prefrontal cortices (vmPFC) and this was correlated with reductions in WMV within vmPFC, suggesting that RD have deficits in memory retrieval. Moreover, these GMV alterations in vmPFC for the RD were correlated with alterations in right parahippocampal gyrus, which also showed a reduced GMV, suggesting that RD have a correlated deficit in memory encoding. Our results ire consistent with previous studies suggesting that Chinese dyslexics have deficits in visuo-orthographic and phonological processing, but our study importantly suggests deficits in memory encoding and retrieval, perhaps due to the unique demands of the Chinese writing system. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Chinese dyslexia Voxel-based morphometry Memory encoding and retrieval
学科领域Cognitive Psychology,developmental Psychology
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收录类别SSCI
语种英语
项目资助者National Natural Science Foundation of China [81030027, 30900362, 30971043] ; National Basic Research Program (973) [2007CB512305/2]
项目简介This study was supported by grants from Chinese National Natural Science Foundation (31000500, 81000603 and 81171016), the Fundamental Research Funds for the Central Universities, Beijing Natural Science Foundation (7102089) and the United States National Institute of Child Health and Human Development (HD042049).
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS类目Behavioral Sciences ; Neurosciences ; Psychology, Experimental
WOS记录号WOS:000321539400004
WOS标题词Science & Technology ; Social Sciences ; Life Sciences & Biomedicine
关键词[WOS]INFERIOR PREFRONTAL CORTEX ; VOXEL-BASED MORPHOMETRY ; DEVELOPMENTAL DYSLEXIA ; GRAY-MATTER ; CONTEXTUAL FACILITATION ; DEFICIT HYPOTHESIS ; FUNCTIONAL-ANATOMY ; MEMORY ; LANGUAGE ; READERS
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10785
专题中国科学院行为科学重点实验室
通讯作者Liu, L (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
3.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China
4.Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA
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Liu, Li,You, Wenping,Wang, Wenjing,et al. Altered brain structure in Chinese dyslexic children[J]. NEUROPSYCHOLOGIA,2013,51(7):1169-1176.
APA Liu, Li.,You, Wenping.,Wang, Wenjing.,Guo, Xiaojuan.,Peng, Danling.,...&Liu, L .(2013).Altered brain structure in Chinese dyslexic children.NEUROPSYCHOLOGIA,51(7),1169-1176.
MLA Liu, Li,et al."Altered brain structure in Chinese dyslexic children".NEUROPSYCHOLOGIA 51.7(2013):1169-1176.
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