The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats

	The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats
	Pan, Yuqin; Lin, Wenjuan; Wang, Weiwen; Qi, Xiaoli; Wang, Donglin; Tang, Mingming; Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
心理所单位排序	1,2
摘要	Although increasing evidence demonstrates that both chronic stressors and inflammatory immune activation contribute to pathophysiology and behavioral alterations associated with major depression, little is known about the interaction effect of central inflammatory immune activation and stress on depressivelike behavior. Our previous work has shown that 14-day chronic forced swim stress induces significant depressive-like behavior. The present investigation assessed whether pro-inflammatory cytokine and anti-inflammatory cytokine challenges have differential interaction effect on depressive-like behavior induced by chronic forced swim stress in rats. The pro-inflammatory and anti-inflammatory immune challenges were achieved respectively by central administration of lipopolysaccharide (LPS), a proinflammatory cytokine inducer, and interleukin-10 (IL-10), an anti-inflammatory cytokine. It was found that either central LPS treatment alone or chronic forced swim stress alone significantly induced depressive-like behavior, including reduced body weight gain, reduced saccharin preference and reduced locomotor activity. However, there was no significant synergistic or additive effect of central LPS treatment and stress on depressive-like behavior. LPS treatment did not exacerbate the depressive-like behavior induced by forced swim stress. Nevertheless, IL-10 reversed depressive-like behavior induced by forced swim stress, a finding indicating that IL-10 has antidepressant effect on behavioral depression induced by stress. The present findings provide new insight into the complexity of the immunityinflammation hypothesis of depression. (C) 2013 Elsevier B.V. All rights reserved.
关键词	Lipopolysaccharide Interleukin-10 Stress Depressive-like behavior
学科领域	Sports Psychology,Health Psychology
	2013
语种	英语
发表期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
卷号	247 页码:232-240
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This research was supported by the grant (31170987,30770718) from the National Natural Science Foundation of China and the grants (KSOC2-2-03, KSOC2-YW-R-131) from the Chinese Academy of Sciences.
WOS关键词	LIPOPOLYSACCHARIDE-INDUCED HYPOACTIVITY ; LIGHT-DARK CYCLE ; TOLERANCE DEVELOPMENT ; INTERLEUKIN-10 IL-10 ; SICKNESS BEHAVIORS ; PLASMA CYTOKINES ; PLUS-MAZE ; MICE ; BRAIN ; ENDOTOXIN
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000319710500031
资助机构	National Natural Science Foundation of China [31170987, 30770718] ; Chinese Academy of Sciences [KSOC2-2-03, KSOC2-YW-R-131]
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/10795
专题	脑与认知科学国家重点实验室
通讯作者	Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
作者单位	Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
第一作者单位	脑与认知科学国家重点实验室
推荐引用方式 GB/T 7714	Pan, Yuqin,Lin, Wenjuan,Wang, Weiwen,et al. The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2013,247:232-240.
APA	Pan, Yuqin.,Lin, Wenjuan.,Wang, Weiwen.,Qi, Xiaoli.,Wang, Donglin.,...&Lin, WJ .(2013).The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats.BEHAVIOURAL BRAIN RESEARCH,247,232-240.
MLA	Pan, Yuqin,et al."The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats".BEHAVIOURAL BRAIN RESEARCH 247(2013):232-240.

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