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The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats
Pan, Yuqin; Lin, Wenjuan; Wang, Weiwen; Qi, Xiaoli; Wang, Donglin; Tang, Mingming; Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
2013
发表期刊BEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
文章类型期刊论文
卷号247页码:232-240
产权排序1,2
摘要Although increasing evidence demonstrates that both chronic stressors and inflammatory immune activation contribute to pathophysiology and behavioral alterations associated with major depression, little is known about the interaction effect of central inflammatory immune activation and stress on depressivelike behavior. Our previous work has shown that 14-day chronic forced swim stress induces significant depressive-like behavior. The present investigation assessed whether pro-inflammatory cytokine and anti-inflammatory cytokine challenges have differential interaction effect on depressive-like behavior induced by chronic forced swim stress in rats. The pro-inflammatory and anti-inflammatory immune challenges were achieved respectively by central administration of lipopolysaccharide (LPS), a proinflammatory cytokine inducer, and interleukin-10 (IL-10), an anti-inflammatory cytokine. It was found that either central LPS treatment alone or chronic forced swim stress alone significantly induced depressive-like behavior, including reduced body weight gain, reduced saccharin preference and reduced locomotor activity. However, there was no significant synergistic or additive effect of central LPS treatment and stress on depressive-like behavior. LPS treatment did not exacerbate the depressive-like behavior induced by forced swim stress. Nevertheless, IL-10 reversed depressive-like behavior induced by forced swim stress, a finding indicating that IL-10 has antidepressant effect on behavioral depression induced by stress. The present findings provide new insight into the complexity of the immunityinflammation hypothesis of depression. (C) 2013 Elsevier B.V. All rights reserved.
关键词Lipopolysaccharide Interleukin-10 Stress Depressive-like behavior
学科领域Sports Psychology,Health Psychology
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [31170987, 30770718] ; Chinese Academy of Sciences [KSOC2-2-03, KSOC2-YW-R-131]
项目简介This research was supported by the grant (31170987,30770718) from the National Natural Science Foundation of China and the grants (KSOC2-2-03, KSOC2-YW-R-131) from the Chinese Academy of Sciences.
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000319710500031
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]LIPOPOLYSACCHARIDE-INDUCED HYPOACTIVITY ; LIGHT-DARK CYCLE ; TOLERANCE DEVELOPMENT ; INTERLEUKIN-10 IL-10 ; SICKNESS BEHAVIORS ; PLASMA CYTOKINES ; PLUS-MAZE ; MICE ; BRAIN ; ENDOTOXIN
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被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10795
专题脑与认知科学国家重点实验室
通讯作者Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
作者单位Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
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Pan, Yuqin,Lin, Wenjuan,Wang, Weiwen,et al. The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2013,247:232-240.
APA Pan, Yuqin.,Lin, Wenjuan.,Wang, Weiwen.,Qi, Xiaoli.,Wang, Donglin.,...&Lin, WJ .(2013).The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats.BEHAVIOURAL BRAIN RESEARCH,247,232-240.
MLA Pan, Yuqin,et al."The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats".BEHAVIOURAL BRAIN RESEARCH 247(2013):232-240.
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