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The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats
Pan, Yuqin; Lin, Wenjuan; Wang, Weiwen; Qi, Xiaoli; Wang, Donglin; Tang, Mingming; Lin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
2013
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
Subtype期刊论文
Volume247Pages:232-240
Contribution Rank1,2
AbstractAlthough increasing evidence demonstrates that both chronic stressors and inflammatory immune activation contribute to pathophysiology and behavioral alterations associated with major depression, little is known about the interaction effect of central inflammatory immune activation and stress on depressivelike behavior. Our previous work has shown that 14-day chronic forced swim stress induces significant depressive-like behavior. The present investigation assessed whether pro-inflammatory cytokine and anti-inflammatory cytokine challenges have differential interaction effect on depressive-like behavior induced by chronic forced swim stress in rats. The pro-inflammatory and anti-inflammatory immune challenges were achieved respectively by central administration of lipopolysaccharide (LPS), a proinflammatory cytokine inducer, and interleukin-10 (IL-10), an anti-inflammatory cytokine. It was found that either central LPS treatment alone or chronic forced swim stress alone significantly induced depressive-like behavior, including reduced body weight gain, reduced saccharin preference and reduced locomotor activity. However, there was no significant synergistic or additive effect of central LPS treatment and stress on depressive-like behavior. LPS treatment did not exacerbate the depressive-like behavior induced by forced swim stress. Nevertheless, IL-10 reversed depressive-like behavior induced by forced swim stress, a finding indicating that IL-10 has antidepressant effect on behavioral depression induced by stress. The present findings provide new insight into the complexity of the immunityinflammation hypothesis of depression. (C) 2013 Elsevier B.V. All rights reserved.
KeywordLipopolysaccharide Interleukin-10 Stress Depressive-like behavior
Subject AreaSports Psychology,Health Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [31170987, 30770718] ; Chinese Academy of Sciences [KSOC2-2-03, KSOC2-YW-R-131]
Project Intro.This research was supported by the grant (31170987,30770718) from the National Natural Science Foundation of China and the grants (KSOC2-2-03, KSOC2-YW-R-131) from the Chinese Academy of Sciences.
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000319710500031
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordLIPOPOLYSACCHARIDE-INDUCED HYPOACTIVITY ; LIGHT-DARK CYCLE ; TOLERANCE DEVELOPMENT ; INTERLEUKIN-10 IL-10 ; SICKNESS BEHAVIORS ; PLASMA CYTOKINES ; PLUS-MAZE ; MICE ; BRAIN ; ENDOTOXIN
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10795
Collection脑与认知科学国家重点实验室
Corresponding AuthorLin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
AffiliationLin, WJ (reprint author), Chinese Acad Sci, Inst Psychol, Brain Behav Res Ctr, Beijing 100101, Peoples R China.
Recommended Citation
GB/T 7714
Pan, Yuqin,Lin, Wenjuan,Wang, Weiwen,et al. The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats[J]. BEHAVIOURAL BRAIN RESEARCH,2013,247:232-240.
APA Pan, Yuqin.,Lin, Wenjuan.,Wang, Weiwen.,Qi, Xiaoli.,Wang, Donglin.,...&Lin, WJ .(2013).The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats.BEHAVIOURAL BRAIN RESEARCH,247,232-240.
MLA Pan, Yuqin,et al."The effects of central pro-and anti-inflammatory immune challenges on depressive-like behavior induced by chronic forced swim stress in rats".BEHAVIOURAL BRAIN RESEARCH 247(2013):232-240.
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