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Adolescent social isolation influences cognitive function in adult rats
Sheo, Feng1; Han, Xiao1; Sheo, Shuang1; Wang, Weiwen2
2013-04-01
发表期刊NEURAL REGENERATION RESEARCH
文章类型Article
卷号8期号:11页码:1025-1030
摘要Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation (isolated housing, 38-51 days of age) and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.
关键词neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophic factor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmental disorders grants-supported paper neuroregeneration
收录类别SCI
语种英语
WOS研究方向Cell Biology ; Neurosciences & Neurology
WOS类目Cell Biology ; Neurosciences
WOS记录号WOS:000318833800008
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]BDNF MESSENGER-RNA ; NEUROTROPHIC FACTOR ; FEMALE RATS ; DOPAMINERGIC-NEURONS ; RECEPTOR EXPRESSION ; LATENT INHIBITION ; PREFRONTAL CORTEX ; BRAIN ; SCHIZOPHRENIA ; STRESS
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10799
专题脑与认知科学国家重点实验室
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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GB/T 7714
Sheo, Feng,Han, Xiao,Sheo, Shuang,et al. Adolescent social isolation influences cognitive function in adult rats[J]. NEURAL REGENERATION RESEARCH,2013,8(11):1025-1030.
APA Sheo, Feng,Han, Xiao,Sheo, Shuang,&Wang, Weiwen.(2013).Adolescent social isolation influences cognitive function in adult rats.NEURAL REGENERATION RESEARCH,8(11),1025-1030.
MLA Sheo, Feng,et al."Adolescent social isolation influences cognitive function in adult rats".NEURAL REGENERATION RESEARCH 8.11(2013):1025-1030.
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