Adolescent social isolation influences cognitive function in adult rats

	Adolescent social isolation influences cognitive function in adult rats
	Sheo, Feng 1; Han, Xiao 1; Sheo, Shuang 1; Wang, Weiwen2
摘要	Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation (isolated housing, 38-51 days of age) and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.
关键词	neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophic factor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmental disorders grants-supported paper neuroregeneration
	2013-04-01
语种	英语
发表期刊	NEURAL REGENERATION RESEARCH
卷号	8 期号:11 页码:1025-1030
期刊论文类型	Article
收录类别	SCI
WOS关键词	BDNF MESSENGER-RNA ; NEUROTROPHIC FACTOR ; FEMALE RATS ; DOPAMINERGIC-NEURONS ; RECEPTOR EXPRESSION ; LATENT INHIBITION ; PREFRONTAL CORTEX ; BRAIN ; SCHIZOPHRENIA ; STRESS
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Cell Biology ; Neurosciences & Neurology
WOS类目	Cell Biology ; Neurosciences
WOS记录号	WOS:000318833800008
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10799
专题	脑与认知科学国家重点实验室
作者单位	1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Sheo, Feng,Han, Xiao,Sheo, Shuang,et al. Adolescent social isolation influences cognitive function in adult rats[J]. NEURAL REGENERATION RESEARCH,2013,8(11):1025-1030.
APA	Sheo, Feng,Han, Xiao,Sheo, Shuang,&Wang, Weiwen.(2013).Adolescent social isolation influences cognitive function in adult rats.NEURAL REGENERATION RESEARCH,8(11),1025-1030.
MLA	Sheo, Feng,et al."Adolescent social isolation influences cognitive function in adult rats".NEURAL REGENERATION RESEARCH 8.11(2013):1025-1030.

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