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Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD
Liao, Yi1; Huang, Xiaoqi1; Wu, Qizhu1; Yang, Chuang2; Kuang, Weihong3; Du, Mingying1; Lui, Su1; Yue, Qiang1; Chan, Raymond C. K.4,5; Kemp, Graham J.6,7; Gong, Qiyong1; Gong, QY (reprint author), Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
2013
Source PublicationJOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN1180-4882
Subtype期刊论文
Volume38Issue:1Pages:49-56
Contribution Rank4
AbstractBackground: Many studies using diffusion tensor imaging (DTI) have demonstrated impaired white matter integrity in patients with major depressive disorder (MDD), with significant results found in diverse brain regions. We sought to identify whether there are consistent changes of regional white matter integrity in patients with MDD, as shown by decreased fractional anisotropy in DTI. Method: A systematic search strategy was used to identify relevant whole brain voxel-based DTI studies of patients with MDD in relation to comparison groups. Relevant databases were searched for studies published between January 1994 and February 2011 using combinations of the terms "DTI" or "diffusion tensor;" "whole brain" or "voxel-based;" and "depress*." Using the studies that met our inclusion criteria, we performed a meta-analysis of the coordinates of decreased fractional anisotropy using the activation likelihood estimation (ALE) method, which detects 3-dimensional conjunctions of coordinates from multiple studies, weighted by sample size. We then used DTIquery software for fibre tracking to locate the fascicles involved in each region. Results: We included 11 studies with a combined sample of 231 patients with MDD and 261 comparison participants, providing 50 coordinates of decreased fractional anisotropy. Our meta-analysis identified 4 consistent locations of decreased fractional anisotropy in patients with MDD: white matter in the right frontal lobe, right fusiform gyrus, left frontal lobe and right occipital lobe. Fibre tracking showed that the main fascicles involved were the right inferior longitudinal fasciculus, right inferior fronto-occipital fasciculus, right posterior thalamic radiation and interhemispheric fibres running through the genu and body of the corpus callosum. Limitations: The number of studies included was relatively small, and the DTI data acquisition and analysis techniques were heterogeneous. The ALE method cannot handle studies with no significant group differences. Conclusion: Voxel-based analysis of DTI studies of patients with MDD consistently identified decreased fractional anisotropy in the white matter fascicles connecting the prefrontal cortex within cortical (frontal, temporal and occipital lobes) and subcortical areas (amygdala and hippocampus). This is strong evidence for the involvement of these neural circuits in the pathology of MDD.
Subject AreaAbnormal Psychology,Emotional Psychology
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Indexed BySSCI
Language英语
Funding OrganizationNational Natural Science Foundation [81171488, 81030027] ; National Key Technologies R&D Program of China [2012BAI01B03]
Project Intro.This study was supported by National Natural Science Foundation (Grant Nos. 81171488 and 81030027) and the National Key Technologies R&D Program of China (Program No: 2012BAI01B03). We would also like to thank Dr. Jun Li for her suggestions regarding statistical methodology.
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectNeurosciences ; Psychiatry
WOS IDWOS:000318039600007
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordLATE-LIFE DEPRESSION ; WHITE-MATTER ABNORMALITIES ; MICROSTRUCTURAL ABNORMALITIES ; MOOD DISORDERS ; BRAIN ; CIRCUITS ; HODOLOGY ; CONNECTIVITY ; ANISOTROPY ; UPDATE
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Cited Times:157[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10807
Collection中国科学院行为科学重点实验室
Corresponding AuthorGong, QY (reprint author), Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
Affiliation1.Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, Chengdu 610041, Peoples R China
2.Wenzhou Med Sch, Dept Psychiat, Wenzhou, Peoples R China
3.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Psychiat, Chengdu 610064, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
6.Univ Liverpool, MARIARC, Liverpool L69 3BX, Merseyside, England
7.Univ Liverpool, Inst Ageing & Chron Dis, Liverpool L69 3BX, Merseyside, England
Recommended Citation
GB/T 7714
Liao, Yi,Huang, Xiaoqi,Wu, Qizhu,et al. Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2013,38(1):49-56.
APA Liao, Yi.,Huang, Xiaoqi.,Wu, Qizhu.,Yang, Chuang.,Kuang, Weihong.,...&Gong, QY .(2013).Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,38(1),49-56.
MLA Liao, Yi,et al."Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 38.1(2013):49-56.
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