PSYCH OpenIR  > 中国科学院行为科学重点实验室
Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD
Liao, Yi1; Huang, Xiaoqi1; Wu, Qizhu1; Yang, Chuang2; Kuang, Weihong3; Du, Mingying1; Lui, Su1; Yue, Qiang1; Chan, Raymond C. K.4,5; Kemp, Graham J.6,7; Gong, Qiyong1; Gong, QY (reprint author), Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
2013
发表期刊JOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN1180-4882
文章类型期刊论文
卷号38期号:1页码:49-56
产权排序4
摘要Background: Many studies using diffusion tensor imaging (DTI) have demonstrated impaired white matter integrity in patients with major depressive disorder (MDD), with significant results found in diverse brain regions. We sought to identify whether there are consistent changes of regional white matter integrity in patients with MDD, as shown by decreased fractional anisotropy in DTI. Method: A systematic search strategy was used to identify relevant whole brain voxel-based DTI studies of patients with MDD in relation to comparison groups. Relevant databases were searched for studies published between January 1994 and February 2011 using combinations of the terms "DTI" or "diffusion tensor;" "whole brain" or "voxel-based;" and "depress*." Using the studies that met our inclusion criteria, we performed a meta-analysis of the coordinates of decreased fractional anisotropy using the activation likelihood estimation (ALE) method, which detects 3-dimensional conjunctions of coordinates from multiple studies, weighted by sample size. We then used DTIquery software for fibre tracking to locate the fascicles involved in each region. Results: We included 11 studies with a combined sample of 231 patients with MDD and 261 comparison participants, providing 50 coordinates of decreased fractional anisotropy. Our meta-analysis identified 4 consistent locations of decreased fractional anisotropy in patients with MDD: white matter in the right frontal lobe, right fusiform gyrus, left frontal lobe and right occipital lobe. Fibre tracking showed that the main fascicles involved were the right inferior longitudinal fasciculus, right inferior fronto-occipital fasciculus, right posterior thalamic radiation and interhemispheric fibres running through the genu and body of the corpus callosum. Limitations: The number of studies included was relatively small, and the DTI data acquisition and analysis techniques were heterogeneous. The ALE method cannot handle studies with no significant group differences. Conclusion: Voxel-based analysis of DTI studies of patients with MDD consistently identified decreased fractional anisotropy in the white matter fascicles connecting the prefrontal cortex within cortical (frontal, temporal and occipital lobes) and subcortical areas (amygdala and hippocampus). This is strong evidence for the involvement of these neural circuits in the pathology of MDD.
学科领域Abnormal Psychology,Emotional Psychology
URL查看原文
收录类别SSCI
语种英语
项目资助者National Natural Science Foundation [81171488, 81030027] ; National Key Technologies R&D Program of China [2012BAI01B03]
项目简介This study was supported by National Natural Science Foundation (Grant Nos. 81171488 and 81030027) and the National Key Technologies R&D Program of China (Program No: 2012BAI01B03). We would also like to thank Dr. Jun Li for her suggestions regarding statistical methodology.
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Neurosciences ; Psychiatry
WOS记录号WOS:000318039600007
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]LATE-LIFE DEPRESSION ; WHITE-MATTER ABNORMALITIES ; MICROSTRUCTURAL ABNORMALITIES ; MOOD DISORDERS ; BRAIN ; CIRCUITS ; HODOLOGY ; CONNECTIVITY ; ANISOTROPY ; UPDATE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10807
专题中国科学院行为科学重点实验室
通讯作者Gong, QY (reprint author), Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
作者单位1.Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, Chengdu 610041, Peoples R China
2.Wenzhou Med Sch, Dept Psychiat, Wenzhou, Peoples R China
3.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Psychiat, Chengdu 610064, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
6.Univ Liverpool, MARIARC, Liverpool L69 3BX, Merseyside, England
7.Univ Liverpool, Inst Ageing & Chron Dis, Liverpool L69 3BX, Merseyside, England
推荐引用方式
GB/T 7714
Liao, Yi,Huang, Xiaoqi,Wu, Qizhu,et al. Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2013,38(1):49-56.
APA Liao, Yi.,Huang, Xiaoqi.,Wu, Qizhu.,Yang, Chuang.,Kuang, Weihong.,...&Gong, QY .(2013).Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,38(1),49-56.
MLA Liao, Yi,et al."Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 38.1(2013):49-56.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000318039600007.(2748KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liao, Yi]的文章
[Huang, Xiaoqi]的文章
[Wu, Qizhu]的文章
百度学术
百度学术中相似的文章
[Liao, Yi]的文章
[Huang, Xiaoqi]的文章
[Wu, Qizhu]的文章
必应学术
必应学术中相似的文章
[Liao, Yi]的文章
[Huang, Xiaoqi]的文章
[Wu, Qizhu]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS_000318039600007.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。