PSYCH OpenIR  > 中国科学院心理健康重点实验室
Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population
Li, Ming1,5; Zhang, Hui1; Luo, Xiong-jian2; Gao, Lei3,5; Qi, Xue-bin1; Gourraud, Pierre-Antoine4; Su, Bing1; Su, B (reprint author), Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China.
2013
发表期刊PLOS ONE
ISSN1932-6203
文章类型期刊论文
卷号8期号:6
产权排序3
摘要Recent genetic association studies have implicated several candidate susceptibility variants for schizophrenia among general populations. Rs1344706, an intronic SNP within ZNF804A, was identified as one of the most compelling candidate risk SNPs for schizophrenia in Europeans through genome-wide association studies (GWASs) and replications as well as large-scale meta-analyses. However, in Han Chinese, the results for rs1344706 are inconsistent, and whether rs1344706 is an authentic risk SNP for schizophrenia in Han Chinese is inconclusive. Here, we conducted a systematic meta-analysis of rs1344706 with schizophrenia in Chinese population by combining all available case-control samples (N = 12), including a total of 8,982 cases and 12,342 controls. The results of our meta-analysis were not able to confirm an association of rs1344706 A-allele with schizophrenia (p = 0.10, odds ratio = 1.06, 95% confidence interval = 0.99-1.13). Such absence of association was further confirmed by the non-superiority test (p = 0.0003), suggesting that rs1344706 is not a risk SNP for schizophrenia in Han Chinese. Detailed examinations of individual samples revealed potential sampling bias in previous replication studies in Han Chinese. The absence of rs1344706 association in Han Chinese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating genome-wide association findings of schizophrenia across different ethnic populations.
学科领域Abnormal Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者National 973 project of China [2011CBA00401] ; National Natural Science Foundation of China [U1202225, 31130051, 31071101]
项目简介This work was supported by grants from the National 973 project of China (grant numbers, 2011CBA00401) and the National Natural Science Foundation of China (U1202225, 31130051 and 31071101). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000320322400055
WOS标题词Science & Technology
关键词[WOS]GENOME-WIDE ASSOCIATION ; COMMON VARIANTS ; SUSCEPTIBILITY ; GENE ; BIAS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10810
专题中国科学院心理健康重点实验室
通讯作者Su, B (reprint author), Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China.
作者单位1.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China
2.Univ Rochester, Flaum Eye Inst, Rochester, NY USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA USA
5.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Ming,Zhang, Hui,Luo, Xiong-jian,et al. Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population[J]. PLOS ONE,2013,8(6).
APA Li, Ming.,Zhang, Hui.,Luo, Xiong-jian.,Gao, Lei.,Qi, Xue-bin.,...&Su, B .(2013).Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population.PLOS ONE,8(6).
MLA Li, Ming,et al."Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population".PLOS ONE 8.6(2013).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000320322400055.(508KB) 限制开放Apache License浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Ming]的文章
[Zhang, Hui]的文章
[Luo, Xiong-jian]的文章
百度学术
百度学术中相似的文章
[Li, Ming]的文章
[Zhang, Hui]的文章
[Luo, Xiong-jian]的文章
必应学术
必应学术中相似的文章
[Li, Ming]的文章
[Zhang, Hui]的文章
[Luo, Xiong-jian]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS_000320322400055.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。