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Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
Deschaux, Olivier1,2; Zheng, Xigeng3; Lavigne, Jennifer1,2; Nachon, Ophelie1,2; Cleren, Carine1,2; Moreau, Jean-Luc4; Garcia, Rene1,2; Deschaux, O (reprint author), Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France.
2013
发表期刊PSYCHOPHARMACOLOGY
ISSN0033-3158
文章类型期刊论文
卷号225期号:1页码:209-216
产权排序3
摘要The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treatment. We sought to examine another potential inducer of fear reemergence, acute stress, in rats and determine whether fluoxetine prevents this phenomenon. Because in previous studies fluoxetine was administered before extinction, we first analyzed its effect on the SCP-associated reemergence of auditory-cued conditioned fear in rats injected after extinction to avoid any interaction between fluoxetine and extinction learning. Next, we used the same protocol but replaced the SCP with acute stress. We found that the SCP and acute stress, which were carried out 3 weeks after fear extinction, similarly provoked the reemergence of extinguished fear in rats injected with vehicle during the 3-week period. In contrast, the animals treated with fluoxetine during this period behaved similarly to those not exposed to an inducer of fear reemergence. Our data establish acute stress as an inducer of fear reemergence. The results provide further support for the hypothesis that fluoxetine interfered with mechanisms that reactivated extinguished fear, even when administered after fear extinction.
关键词Conditioned freezing Fear reemergence Stress and extinction memory Antidepressant Rats
学科领域Emotional Psychology
收录类别SCI
语种英语
项目资助者University of Nice-Sophia Antipolis ; Chinese Academy of Science
项目简介This study was supported by F. Hoffmann-La Roche (J.L.M), the University of Nice-Sophia Antipolis (O.D., J.L., O.N., C. C., R. G.), and The Chinese Academy of Science (X.Z.). We thank Michael Arends for reviewing the English style of the manuscript.
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000313163900018
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CONDITIONED FEAR ; PREFRONTAL CORTEX ; SPONTANEOUS-RECOVERY ; RETRIEVAL ; ANTIDEPRESSANTS ; HIPPOCAMPAL ; IMPAIRS ; MEMORY ; RATS ; CONSOLIDATION
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被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10812
专题中国科学院心理健康重点实验室
通讯作者Deschaux, O (reprint author), Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France.
作者单位1.Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France
2.Univ Aix Marseille 2, CNRS, UMR 7289, Inst Neurosci Timone, F-13385 Marseille, France
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Hoffmann La Roche AG, Div Pharma, Basel, Switzerland
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Deschaux, Olivier,Zheng, Xigeng,Lavigne, Jennifer,et al. Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear[J]. PSYCHOPHARMACOLOGY,2013,225(1):209-216.
APA Deschaux, Olivier.,Zheng, Xigeng.,Lavigne, Jennifer.,Nachon, Ophelie.,Cleren, Carine.,...&Deschaux, O .(2013).Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear.PSYCHOPHARMACOLOGY,225(1),209-216.
MLA Deschaux, Olivier,et al."Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear".PSYCHOPHARMACOLOGY 225.1(2013):209-216.
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