Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear

	Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear
	Deschaux, Olivier 1,2; Zheng, Xigeng3 ; Lavigne, Jennifer 1,2; Nachon, Ophelie 1,2; Cleren, Carine 1,2; Moreau, Jean-Luc 4; Garcia, Rene 1,2; Deschaux, O (reprint author), Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France.
心理所单位排序	3
摘要	The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treatment. We sought to examine another potential inducer of fear reemergence, acute stress, in rats and determine whether fluoxetine prevents this phenomenon. Because in previous studies fluoxetine was administered before extinction, we first analyzed its effect on the SCP-associated reemergence of auditory-cued conditioned fear in rats injected after extinction to avoid any interaction between fluoxetine and extinction learning. Next, we used the same protocol but replaced the SCP with acute stress. We found that the SCP and acute stress, which were carried out 3 weeks after fear extinction, similarly provoked the reemergence of extinguished fear in rats injected with vehicle during the 3-week period. In contrast, the animals treated with fluoxetine during this period behaved similarly to those not exposed to an inducer of fear reemergence. Our data establish acute stress as an inducer of fear reemergence. The results provide further support for the hypothesis that fluoxetine interfered with mechanisms that reactivated extinguished fear, even when administered after fear extinction.
关键词	Conditioned freezing Fear reemergence Stress and extinction memory Antidepressant Rats
学科领域	Emotional Psychology
	2013
语种	英语
发表期刊	PSYCHOPHARMACOLOGY
ISSN	0033-3158
卷号	225 期号:1 页码:209-216
期刊论文类型	期刊论文
收录类别	SCI
项目简介	This study was supported by F. Hoffmann-La Roche (J.L.M), the University of Nice-Sophia Antipolis (O.D., J.L., O.N., C. C., R. G.), and The Chinese Academy of Science (X.Z.). We thank Michael Arends for reviewing the English style of the manuscript.
WOS关键词	CONDITIONED FEAR ; PREFRONTAL CORTEX ; SPONTANEOUS-RECOVERY ; RETRIEVAL ; ANTIDEPRESSANTS ; HIPPOCAMPAL ; IMPAIRS ; MEMORY ; RATS ; CONSOLIDATION
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000313163900018
资助机构	University of Nice-Sophia Antipolis ; Chinese Academy of Science
引用统计	被引频次：53[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10812
专题	中国科学院心理健康重点实验室
通讯作者	Deschaux, O (reprint author), Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France.
作者单位	1.Univ Nice Sophia Antipolis, Fac Sci, Dept Sci Vie, F-06108 Nice, France 2.Univ Aix Marseille 2, CNRS, UMR 7289, Inst Neurosci Timone, F-13385 Marseille, France 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Hoffmann La Roche AG, Div Pharma, Basel, Switzerland
推荐引用方式 GB/T 7714	Deschaux, Olivier,Zheng, Xigeng,Lavigne, Jennifer,et al. Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear[J]. PSYCHOPHARMACOLOGY,2013,225(1):209-216.
APA	Deschaux, Olivier.,Zheng, Xigeng.,Lavigne, Jennifer.,Nachon, Ophelie.,Cleren, Carine.,...&Deschaux, O .(2013).Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear.PSYCHOPHARMACOLOGY,225(1),209-216.
MLA	Deschaux, Olivier,et al."Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear".PSYCHOPHARMACOLOGY 225.1(2013):209-216.

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