Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder | |
Zhao, Qing1,2 ; Ma, Yan-tao3; Lui, Simon S. Y.1,2,4; Liu, Wen-hua5; Xu, Ting1,2; Yu, Xin3; Tan, Shu-Ping6; Wang, Zhi-ren6; Qu, Miao7; Wang, Ya1; Huang, Jia1; Cheung, Eric F. C.4; Dazzan, Paola8; Chan, Raymond C. K.1; Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
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| 心理所单位排序 | 1 |
| 摘要 | Background: Neurological soft signs (NSS) are minor neurological abnormalities, including motor, sensory, and inhibitory dysfunction. Schizophrenia and other neuropsychiatric disorders are associated with a higher prevalence of NSS. However, the relationships between NSS and schizophrenia, bipolar disorder, and major depression are unclear. The present study aimed to examine the specificity of NSS among these three clinical groups. Method: A total of 120 demographically matched participants (30 each in schizophrenia, bipolar disorder, major depression, and healthy controls) were recruited for the study. NSS subscales of the Cambridge Neurological Inventory (CNI) were administered to each participant. Results: Significant differences were found in the total score of NSS (p<0.01), and the subscale scores for motor coordination (p<0.01), sensory integration (p = 0.01) and disinhibition (p<0.01). Both patients with schizophrenia and bipolar disorder showed more total NSS signs than healthy controls (p<0.01). Patients with schizophrenia also showed more total NSS signs than patients with major depression (p = 0.02). Both patients with schizophrenia and patients with bipolar disorder showed more motor coordination signs than healthy controls and patients with major depression (p<0.05). Moreover, compared with healthy controls, patients with schizophrenia showed more disinhibition signs (p<0.01), while patients with bipolar disorder showed more sensory integration signs (p<0.01). Discriminant analysis showed 77.5% of correct classification of patients with schizophrenia and bipolar disorder from patients with major depression and healthy controls. Conclusions: NSS are not unique to schizophrenia, but are also found in bipolar disorder, while patients with major depression are comparable to normal controls. Our results suggest that NSS, especially motor-coordination signs, can differentiate schizophrenia from major depression but not bipolar disorder. Our results may provide further evidence to support the similarity between schizophrenia and bipolar disorder from the dimension of behavioral expression. (c) 2012 Elsevier Inc. All rights reserved. |
| 关键词 | Bipolar disorder Discriminant analysis Major depression Neurological soft signs Prevalence rate Schizophrenia |
| 学科领域 | Abnormal Psychology |
| 2013 | |
| 语种 | 英语 |
| 发表期刊 | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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| ISSN | 0278-5846 |
| 卷号 | 43页码:72-78 |
| 期刊论文类型 | 期刊论文 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | This study was supported by the National Science Foundation China Outstanding Young Investigator Award (81088001), the National Key Technologies R&D Programme (2012BAI36B01), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology to Raymond Chan. Dr. P. Dazzan is supported by NARSAD and the BIAL Foundation. |
| WOS关键词 | 1ST-EPISODE SCHIZOPHRENIA ; PSYCHOSIS ; SCALE ; ABNORMALITIES ; INSTRUMENT ; INVENTORY ; CONTINUUM ; FEATURES ; REELIN |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| WOS记录号 | WOS:000317878700010 |
| 资助机构 | National Science Foundation China Outstanding Young Investigator Award [81088001] ; National Key Technologies RD Programme [2012BAI36B01] ; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology ; NARSAD ; BIAL Foundation |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/10824 |
| 专题 | 脑与认知科学国家重点实验室 |
| 通讯作者 | Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Peking Univ, Inst Mental Hlth, Affiliated Hosp 6, Beijing 100871, Peoples R China 4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 5.Guangzhou Med Univ, Fac Humanities & Social Sci, Guangzhou, Guangdong, Peoples R China 6.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China 7.Beijing Univ Chinese Med, Affiliated Hosp 3, Encephalopathy Dept, Beijing, Peoples R China 8.Kings Coll London, Inst Psychiat, London WC2R 2LS, England |
| 第一作者单位 | 认知与发展心理学研究室 |
| 推荐引用方式 GB/T 7714 | Zhao, Qing,Ma, Yan-tao,Lui, Simon S. Y.,et al. Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,43:72-78. |
| APA | Zhao, Qing.,Ma, Yan-tao.,Lui, Simon S. Y..,Liu, Wen-hua.,Xu, Ting.,...&Chan, RCK .(2013).Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,43,72-78. |
| MLA | Zhao, Qing,et al."Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 43(2013):72-78. |
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