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Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder
Zhao, Qing1,2; Ma, Yan-tao3; Lui, Simon S. Y.1,2,4; Liu, Wen-hua5; Xu, Ting1,2; Yu, Xin3; Tan, Shu-Ping6; Wang, Zhi-ren6; Qu, Miao7; Wang, Ya1; Huang, Jia1; Cheung, Eric F. C.4; Dazzan, Paola8; Chan, Raymond C. K.1; Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
2013
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
Subtype期刊论文
Volume43Pages:72-78
Contribution Rank1
AbstractBackground: Neurological soft signs (NSS) are minor neurological abnormalities, including motor, sensory, and inhibitory dysfunction. Schizophrenia and other neuropsychiatric disorders are associated with a higher prevalence of NSS. However, the relationships between NSS and schizophrenia, bipolar disorder, and major depression are unclear. The present study aimed to examine the specificity of NSS among these three clinical groups. Method: A total of 120 demographically matched participants (30 each in schizophrenia, bipolar disorder, major depression, and healthy controls) were recruited for the study. NSS subscales of the Cambridge Neurological Inventory (CNI) were administered to each participant. Results: Significant differences were found in the total score of NSS (p<0.01), and the subscale scores for motor coordination (p<0.01), sensory integration (p = 0.01) and disinhibition (p<0.01). Both patients with schizophrenia and bipolar disorder showed more total NSS signs than healthy controls (p<0.01). Patients with schizophrenia also showed more total NSS signs than patients with major depression (p = 0.02). Both patients with schizophrenia and patients with bipolar disorder showed more motor coordination signs than healthy controls and patients with major depression (p<0.05). Moreover, compared with healthy controls, patients with schizophrenia showed more disinhibition signs (p<0.01), while patients with bipolar disorder showed more sensory integration signs (p<0.01). Discriminant analysis showed 77.5% of correct classification of patients with schizophrenia and bipolar disorder from patients with major depression and healthy controls. Conclusions: NSS are not unique to schizophrenia, but are also found in bipolar disorder, while patients with major depression are comparable to normal controls. Our results suggest that NSS, especially motor-coordination signs, can differentiate schizophrenia from major depression but not bipolar disorder. Our results may provide further evidence to support the similarity between schizophrenia and bipolar disorder from the dimension of behavioral expression. (c) 2012 Elsevier Inc. All rights reserved.
KeywordBipolar disorder Discriminant analysis Major depression Neurological soft signs Prevalence rate Schizophrenia
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationNational Science Foundation China Outstanding Young Investigator Award [81088001] ; National Key Technologies RD Programme [2012BAI36B01] ; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of Psychology ; NARSAD ; BIAL Foundation
Project Intro.This study was supported by the National Science Foundation China Outstanding Young Investigator Award (81088001), the National Key Technologies R&D Programme (2012BAI36B01), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of Psychology to Raymond Chan. Dr. P. Dazzan is supported by NARSAD and the BIAL Foundation.
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000317878700010
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS Keyword1ST-EPISODE SCHIZOPHRENIA ; PSYCHOSIS ; SCALE ; ABNORMALITIES ; INSTRUMENT ; INVENTORY ; CONTINUUM ; FEATURES ; REELIN
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Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10824
Collection脑与认知科学国家重点实验室
Corresponding AuthorChan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Affiliated Hosp 6, Beijing 100871, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Guangzhou Med Univ, Fac Humanities & Social Sci, Guangzhou, Guangdong, Peoples R China
6.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
7.Beijing Univ Chinese Med, Affiliated Hosp 3, Encephalopathy Dept, Beijing, Peoples R China
8.Kings Coll London, Inst Psychiat, London WC2R 2LS, England
Recommended Citation
GB/T 7714
Zhao, Qing,Ma, Yan-tao,Lui, Simon S. Y.,et al. Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2013,43:72-78.
APA Zhao, Qing.,Ma, Yan-tao.,Lui, Simon S. Y..,Liu, Wen-hua.,Xu, Ting.,...&Chan, RCK .(2013).Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,43,72-78.
MLA Zhao, Qing,et al."Neurological soft signs discriminate schizophrenia from major depression but not bipolar disorder".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 43(2013):72-78.
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