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Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment
Broster, Lucas S.; Li, Juan; Smith, Charles D.; Jicha, Gregory A.; Schmitt, Frederick A.; Jiang, Yang; Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA.
2013
发表期刊JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
ISSN1537-4416
文章类型期刊论文
卷号35期号:9页码:946-959
产权排序2
摘要Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.
关键词Alzheimer disease Mild cognitive impairment Working memory Repetition priming Neuropsychological tests Cognitive therapy Aging
学科领域Cognitive Psychology
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收录类别SCI
语种英语
项目资助者Department of Energy [DE-AC03-OR22725] ; National Institute of Health [P50 AG05144-21, AG000986, 5P30AG028383, 5 T32 AG 242-18, UL1RR033173, UL1TR000117] ; University of Kentucky Department of Behavioral Science
项目简介This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.
WOS研究方向Psychology ; Neurosciences & Neurology
WOS类目Psychology, Clinical ; Clinical Neurology ; Psychology
WOS记录号WOS:000325959200006
WOS标题词Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ALZHEIMERS ASSOCIATION WORKGROUPS ; INDEPENDENT COMPONENT ANALYSIS ; FREE-RECALL PERFORMANCE ; HEALTHY OLDER-ADULTS ; IMPLICIT MEMORY ; EPISODIC MEMORY ; SELECTIVE ATTENTION ; NEURAL MECHANISMS ; EXPLICIT MEMORY ; FUNCTIONAL CONNECTIVITY
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10828
专题中国科学院心理健康重点实验室
通讯作者Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA.
作者单位Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA.
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Broster, Lucas S.,Li, Juan,Smith, Charles D.,et al. Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,2013,35(9):946-959.
APA Broster, Lucas S..,Li, Juan.,Smith, Charles D..,Jicha, Gregory A..,Schmitt, Frederick A..,...&Jiang, Y .(2013).Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment.JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,35(9),946-959.
MLA Broster, Lucas S.,et al."Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment".JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 35.9(2013):946-959.
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