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Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment
Broster, Lucas S.; Li, Juan; Smith, Charles D.; Jicha, Gregory A.; Schmitt, Frederick A.; Jiang, Yang; Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA.
2013
Source PublicationJOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
ISSN1537-4416
Subtype期刊论文
Volume35Issue:9Pages:946-959
Contribution Rank2
AbstractStudy of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk.
KeywordAlzheimer disease Mild cognitive impairment Working memory Repetition priming Neuropsychological tests Cognitive therapy Aging
Subject AreaCognitive Psychology
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Indexed BySCI
Language英语
Funding OrganizationDepartment of Energy [DE-AC03-OR22725] ; National Institute of Health [P50 AG05144-21, AG000986, 5P30AG028383, 5 T32 AG 242-18, UL1RR033173, UL1TR000117] ; University of Kentucky Department of Behavioral Science
Project Intro.This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science.
WOS Research AreaPsychology ; Neurosciences & Neurology
WOS SubjectPsychology, Clinical ; Clinical Neurology ; Psychology
WOS IDWOS:000325959200006
WOS HeadingsSocial Sciences ; Science & Technology ; Life Sciences & Biomedicine
WOS KeywordALZHEIMERS ASSOCIATION WORKGROUPS ; INDEPENDENT COMPONENT ANALYSIS ; FREE-RECALL PERFORMANCE ; HEALTHY OLDER-ADULTS ; IMPLICIT MEMORY ; EPISODIC MEMORY ; SELECTIVE ATTENTION ; NEURAL MECHANISMS ; EXPLICIT MEMORY ; FUNCTIONAL CONNECTIVITY
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10828
Collection中国科学院心理健康重点实验室
Corresponding AuthorJiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA.
AffiliationJiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA.
Recommended Citation
GB/T 7714
Broster, Lucas S.,Li, Juan,Smith, Charles D.,et al. Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,2013,35(9):946-959.
APA Broster, Lucas S..,Li, Juan.,Smith, Charles D..,Jicha, Gregory A..,Schmitt, Frederick A..,...&Jiang, Y .(2013).Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment.JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,35(9),946-959.
MLA Broster, Lucas S.,et al."Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment".JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 35.9(2013):946-959.
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