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Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment | |
Broster, Lucas S.; Li, Juan; Smith, Charles D.; Jicha, Gregory A.; Schmitt, Frederick A.; Jiang, Yang; Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA. | |
心理所单位排序 | 2 |
摘要 | Study of repeated learning mechanisms has been limited in amnestic mild cognitive impairment, a preclinical stage of Alzheimer disease modifiable by cognitive rehabilitation. We assessed repeated contextual working memory decline as an indicator of amnestic mild cognitive impairment in a sample of 45 older adults recruited from the tertiary care setting. Results indicated that contextual working memory impairment distinguished adults with preclinical disease from those without impairment despite similar overall cognitive performance, and comparison of the indicator with standard-of-care neuropsychological measures indicated discriminant validity. Contextual working memory impairment may represent a novel predictor of Alzheimer disease conversion risk. |
关键词 | Alzheimer disease Mild cognitive impairment Working memory Repetition priming Neuropsychological tests Cognitive therapy Aging |
学科领域 | Cognitive Psychology |
2013 | |
语种 | 英语 |
发表期刊 | JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
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ISSN | 1537-4416 |
卷号 | 35期号:9页码:946-959 |
期刊论文类型 | 期刊论文 |
URL | 查看原文 |
收录类别 | SCI |
项目简介 | This work was supported by funding from the Department of Energy [grant number DE-AC03-OR22725]; the National Institute of Health [grant number P50 AG05144-21], [grant number AG000986], [grant number 5P30AG028383], [grant number 5 T32 AG 242-18], [grant number UL1RR033173], [grant number UL1TR000117]; and a pilot grant from the University of Kentucky Department of Behavioral Science. |
WOS关键词 | ALZHEIMERS ASSOCIATION WORKGROUPS ; INDEPENDENT COMPONENT ANALYSIS ; FREE-RECALL PERFORMANCE ; HEALTHY OLDER-ADULTS ; IMPLICIT MEMORY ; EPISODIC MEMORY ; SELECTIVE ATTENTION ; NEURAL MECHANISMS ; EXPLICIT MEMORY ; FUNCTIONAL CONNECTIVITY |
WOS标题词 | Social Sciences ; Science & Technology ; Life Sciences & Biomedicine |
WOS研究方向 | Psychology ; Neurosciences & Neurology |
WOS类目 | Psychology, Clinical ; Clinical Neurology ; Psychology |
WOS记录号 | WOS:000325959200006 |
资助机构 | Department of Energy [DE-AC03-OR22725] ; National Institute of Health [P50 AG05144-21, AG000986, 5P30AG028383, 5 T32 AG 242-18, UL1RR033173, UL1TR000117] ; University of Kentucky Department of Behavioral Science |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/10828 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA. |
作者单位 | Jiang, Y (reprint author), Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA. |
推荐引用方式 GB/T 7714 | Broster, Lucas S.,Li, Juan,Smith, Charles D.,et al. Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,2013,35(9):946-959. |
APA | Broster, Lucas S..,Li, Juan.,Smith, Charles D..,Jicha, Gregory A..,Schmitt, Frederick A..,...&Jiang, Y .(2013).Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment.JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,35(9),946-959. |
MLA | Broster, Lucas S.,et al."Repeated retrieval during working memory is sensitive to amnestic mild cognitive impairment".JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 35.9(2013):946-959. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
WOS000325959200006.p(307KB) | 限制开放 | Apache License | 请求全文 |
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