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Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm
Feng, Min1,2,3; Sui, Nan1; Li, Ming2; Li, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA.
2013
Source PublicationBEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
Subtype期刊论文
Volume238Pages:178-187
Contribution Rank1
AbstractRepeated administration of antipsychotic drugs induces a sensitization-like or tolerance-like effect in many behavioral tasks, including the conditioned avoidance response (CAR) and the phencyclidine (PCP)-induced hyperlocomotion, two rodent models with high predictive validity for antipsychotic activity. This study investigated the impacts of contextual and behavioral variables on the expression of clozapine tolerance using a recently validated across-model transfer paradigm (Zhang and Li, 2012 [1]). Male Sprague-Dawley rats were first repeatedly treated with clozapine (2.5-10.0 mg/kg, sc) in the CAR model or PCP (1.6 mg/kg, sc)-induced hyperlocomotion model for five consecutive days. They were then tested for the expression of clozapine tolerance in another model for another 5 days. Finally, all rats were switched back to the original model and tested again for the expression of clozapine tolerance. When tested in the PCP model, rats previously treated with clozapine in the CAR model did not show an immediate weaker inhibition of PCP-induced hyperlocomotion than those treated with clozapine for the first time, but showed a significantly weaker inhibition over time. In contrast, when tested in the CAR model, rats previously treated with clozapine in the PCP model showed an immediate weaker disruption of avoidance response than those treated with clozapine for the first time, but this weaker effect diminished over time. These results suggest that the expression of clozapine tolerance is strongly modulated by the test environment and/or selected behavioral response. Clozapine tolerance and its situational specificity may be related to the drug's low extrapyramidal motor side effect, its superior therapeutic efficacy and/or emergence of clozapine withdrawal syndrome. (c) 2012 Elsevier B.V. All rights reserved.
KeywordClozapine Conditioned avoidance response Phencyclidine Motor activity Tolerance Contextual control
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationNIMH grant [R01MH085635]
Project Intro.This study was funded by the NIMH grant (R01MH085635) to Professor Ming Li.
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology
WOS SubjectBehavioral Sciences ; Neurosciences
WOS IDWOS:000314138800023
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCONDITIONED AVOIDANCE-RESPONSE ; PHENCYCLIDINE-INDUCED HYPERLOCOMOTION ; IN-VIVO OCCUPANCY ; ANTIPSYCHOTIC-DRUGS ; ANIMAL-MODELS ; SENSITIZATION ; RATS ; HALOPERIDOL ; DOPAMINE ; OLANZAPINE
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10843
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Feng, Min,Sui, Nan,Li, Ming,et al. Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm[J]. BEHAVIOURAL BRAIN RESEARCH,2013,238:178-187.
APA Feng, Min,Sui, Nan,Li, Ming,&Li, M .(2013).Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm.BEHAVIOURAL BRAIN RESEARCH,238,178-187.
MLA Feng, Min,et al."Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm".BEHAVIOURAL BRAIN RESEARCH 238(2013):178-187.
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