Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm

	Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm
	Feng, Min1,2,3 ; Sui, Nan1 ; Li, Ming 2; Li, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA.
心理所单位排序	1
摘要	Repeated administration of antipsychotic drugs induces a sensitization-like or tolerance-like effect in many behavioral tasks, including the conditioned avoidance response (CAR) and the phencyclidine (PCP)-induced hyperlocomotion, two rodent models with high predictive validity for antipsychotic activity. This study investigated the impacts of contextual and behavioral variables on the expression of clozapine tolerance using a recently validated across-model transfer paradigm (Zhang and Li, 2012 [1]). Male Sprague-Dawley rats were first repeatedly treated with clozapine (2.5-10.0 mg/kg, sc) in the CAR model or PCP (1.6 mg/kg, sc)-induced hyperlocomotion model for five consecutive days. They were then tested for the expression of clozapine tolerance in another model for another 5 days. Finally, all rats were switched back to the original model and tested again for the expression of clozapine tolerance. When tested in the PCP model, rats previously treated with clozapine in the CAR model did not show an immediate weaker inhibition of PCP-induced hyperlocomotion than those treated with clozapine for the first time, but showed a significantly weaker inhibition over time. In contrast, when tested in the CAR model, rats previously treated with clozapine in the PCP model showed an immediate weaker disruption of avoidance response than those treated with clozapine for the first time, but this weaker effect diminished over time. These results suggest that the expression of clozapine tolerance is strongly modulated by the test environment and/or selected behavioral response. Clozapine tolerance and its situational specificity may be related to the drug's low extrapyramidal motor side effect, its superior therapeutic efficacy and/or emergence of clozapine withdrawal syndrome. (c) 2012 Elsevier B.V. All rights reserved.
关键词	Clozapine Conditioned avoidance response Phencyclidine Motor activity Tolerance Contextual control
学科领域	Abnormal Psychology
	2013
语种	英语
发表期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
卷号	238 页码:178-187
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was funded by the NIMH grant (R01MH085635) to Professor Ming Li.
WOS关键词	CONDITIONED AVOIDANCE-RESPONSE ; PHENCYCLIDINE-INDUCED HYPERLOCOMOTION ; IN-VIVO OCCUPANCY ; ANTIPSYCHOTIC-DRUGS ; ANIMAL-MODELS ; SENSITIZATION ; RATS ; HALOPERIDOL ; DOPAMINE ; OLANZAPINE
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000314138800023
资助机构	NIMH grant [R01MH085635]
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/10843
专题	中国科学院心理健康重点实验室
通讯作者	Li, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Feng, Min,Sui, Nan,Li, Ming,et al. Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm[J]. BEHAVIOURAL BRAIN RESEARCH,2013,238:178-187.
APA	Feng, Min,Sui, Nan,Li, Ming,&Li, M .(2013).Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm.BEHAVIOURAL BRAIN RESEARCH,238,178-187.
MLA	Feng, Min,et al."Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm".BEHAVIOURAL BRAIN RESEARCH 238(2013):178-187.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000314138800023.（1434KB）			开放获取	Apache License	浏览下载