PSYCH OpenIR  > 中国科学院心理健康重点实验室
Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm
Feng, Min1,2,3; Sui, Nan1; Li, Ming2; Li, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA.
2013
发表期刊BEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
文章类型期刊论文
卷号238页码:178-187
产权排序1
摘要Repeated administration of antipsychotic drugs induces a sensitization-like or tolerance-like effect in many behavioral tasks, including the conditioned avoidance response (CAR) and the phencyclidine (PCP)-induced hyperlocomotion, two rodent models with high predictive validity for antipsychotic activity. This study investigated the impacts of contextual and behavioral variables on the expression of clozapine tolerance using a recently validated across-model transfer paradigm (Zhang and Li, 2012 [1]). Male Sprague-Dawley rats were first repeatedly treated with clozapine (2.5-10.0 mg/kg, sc) in the CAR model or PCP (1.6 mg/kg, sc)-induced hyperlocomotion model for five consecutive days. They were then tested for the expression of clozapine tolerance in another model for another 5 days. Finally, all rats were switched back to the original model and tested again for the expression of clozapine tolerance. When tested in the PCP model, rats previously treated with clozapine in the CAR model did not show an immediate weaker inhibition of PCP-induced hyperlocomotion than those treated with clozapine for the first time, but showed a significantly weaker inhibition over time. In contrast, when tested in the CAR model, rats previously treated with clozapine in the PCP model showed an immediate weaker disruption of avoidance response than those treated with clozapine for the first time, but this weaker effect diminished over time. These results suggest that the expression of clozapine tolerance is strongly modulated by the test environment and/or selected behavioral response. Clozapine tolerance and its situational specificity may be related to the drug's low extrapyramidal motor side effect, its superior therapeutic efficacy and/or emergence of clozapine withdrawal syndrome. (c) 2012 Elsevier B.V. All rights reserved.
关键词Clozapine Conditioned avoidance response Phencyclidine Motor activity Tolerance Contextual control
学科领域Abnormal Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者NIMH grant [R01MH085635]
项目简介This study was funded by the NIMH grant (R01MH085635) to Professor Ming Li.
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
WOS记录号WOS:000314138800023
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CONDITIONED AVOIDANCE-RESPONSE ; PHENCYCLIDINE-INDUCED HYPERLOCOMOTION ; IN-VIVO OCCUPANCY ; ANTIPSYCHOTIC-DRUGS ; ANIMAL-MODELS ; SENSITIZATION ; RATS ; HALOPERIDOL ; DOPAMINE ; OLANZAPINE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10843
专题中国科学院心理健康重点实验室
通讯作者Li, M (reprint author), Univ Nebraska, Dept Psychol, 238 Burnett Hall, Lincoln, NE 68588 USA.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Feng, Min,Sui, Nan,Li, Ming,et al. Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm[J]. BEHAVIOURAL BRAIN RESEARCH,2013,238:178-187.
APA Feng, Min,Sui, Nan,Li, Ming,&Li, M .(2013).Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm.BEHAVIOURAL BRAIN RESEARCH,238,178-187.
MLA Feng, Min,et al."Environmental and behavioral controls of the expression of clozapine tolerance: Evidence from a novel across-model transfer paradigm".BEHAVIOURAL BRAIN RESEARCH 238(2013):178-187.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000314138800023.(1434KB) 限制开放Apache License浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Feng, Min]的文章
[Sui, Nan]的文章
[Li, Ming]的文章
百度学术
百度学术中相似的文章
[Feng, Min]的文章
[Sui, Nan]的文章
[Li, Ming]的文章
必应学术
必应学术中相似的文章
[Feng, Min]的文章
[Sui, Nan]的文章
[Li, Ming]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS_000314138800023.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。