Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors

	Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors
	Chen, Long 1,2; Lui, Su 1; Wu, Qi-Zhu 1; Zhang, Wei2 ; Zhou, Dong 2; Chen, Hua-Fu 3; Huang, Xiao-Qi 1; Kuang, Wei-Hong 2; Chan, Raymond C.4; Mechelli, Andrea 5; Gong, Qi-Yong 1; Gong, QY (reprint author), Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
心理所单位排序	4
摘要	A characterization of the impact of natural disasters on the brain of survivors is critical for a better understanding of posttraumatic responses and may inform the development of more effective early interventions. Here we report alterations in white matter microstructure in survivors soon after Wenchuan earthquake in China in 2008. Within 25 days after the Wenchuan earthquake, 44 healthy survivors were recruited and scanned on a 3T MR imaging system. The survivors were divided into two groups according to their self-rating anxiety scale (SAS) score, including the SAS(+) (SAS > 55 after correction) group and SAS(-) (SAS < 55 after correction) group. Thrity-two healthy volunteers were also recruited as control group before earthquake. Individual maps of fractional anisotropy (FA) were calculated and voxel-based analysis (VBA) was performed to allow the comparison between survivors and controls using ANCOVAs in SPM2. In addition, a correlation between SAS score and regional FA value was examined using Pearson's correlation analysis in SPSS 11.5. Compared with the healthy cohort, the whole group of 44 survivors showed significantly decreased FA values in the right prefrontal lobe, the parietal lobe, the basal ganglia, and the right parahippocampus. These effects did not appear to depend on self-rating anxiety. For the first time we provide evidence that acute trauma altered cerebral microstructure within the limbic system; furthermore, these alterations are evident shortly after the traumatic event, highlighting the need for early evaluation and intervention for trauma survivors. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.
关键词	stress depression PTSD earthquake MRI diffusion tensor imaging
学科领域	Trauma Psychology,
	2013
语种	英语
发表期刊	HUMAN BRAIN MAPPING
ISSN	1065-9471
卷号	34 期号:2 页码:367-373
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	Contract grant sponsor: National Basic Research Program of China; Contract grant numbers: 973 Program 2007CB512305/2; Contract grant sponsor: National Natural Science Foundation; Contract grant numbers: 81030027 and 30900361; Contract grant sponsor: the Distinguished Young Scholars of Sichuan; Contract grant numbers: 2011JQ0005; Contract grant sponsor: the Programs for New Century Excellent Talents in University; Contract grant numbers: NCET-10-0596; Dr QY Gong also acknowledges the support from the American CMB Distinguished Professorship Award administered by the Institute of International Education, USA.
WOS关键词	WHITE-MATTER ; NEUROIMAGING EVIDENCE ; DISORDER ; ARCHITECTURE ; ACTIVATION ; DEPRESSION ; IMAGES ; MEMORY ; PTSD
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000313115000010
资助机构	National Basic Research Program of China [2007CB512305/2] ; National Natural Science Foundation [81030027, 30900361] ; Distinguished Young Scholars of Sichuan [2011JQ0005] ; Programs for New Century Excellent Talents in University [NCET-10-0596] ; American CMB
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10846
专题	脑与认知科学国家重点实验室
通讯作者	Gong, QY (reprint author), Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
作者单位	1.Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, Chengdu 610041, Peoples R China 2.Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Dept Neurol & Psychiat, Chengdu 610041, Peoples R China 3.Univ Elect Sci & Technol China, Sch Sci & Technol, Brain Funct Lab, Chengdu 610054, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 5.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England
推荐引用方式 GB/T 7714	Chen, Long,Lui, Su,Wu, Qi-Zhu,et al. Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors[J]. HUMAN BRAIN MAPPING,2013,34(2):367-373.
APA	Chen, Long.,Lui, Su.,Wu, Qi-Zhu.,Zhang, Wei.,Zhou, Dong.,...&Gong, QY .(2013).Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors.HUMAN BRAIN MAPPING,34(2),367-373.
MLA	Chen, Long,et al."Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors".HUMAN BRAIN MAPPING 34.2(2013):367-373.

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