PSYCH OpenIR  > 脑与认知科学国家重点实验室
Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors
Chen, Long1,2; Lui, Su1; Wu, Qi-Zhu1; Zhang, Wei2; Zhou, Dong2; Chen, Hua-Fu3; Huang, Xiao-Qi1; Kuang, Wei-Hong2; Chan, Raymond C.4; Mechelli, Andrea5; Gong, Qi-Yong1; Gong, QY (reprint author), Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
2013
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
Subtype期刊论文
Volume34Issue:2Pages:367-373
Contribution Rank4
AbstractA characterization of the impact of natural disasters on the brain of survivors is critical for a better understanding of posttraumatic responses and may inform the development of more effective early interventions. Here we report alterations in white matter microstructure in survivors soon after Wenchuan earthquake in China in 2008. Within 25 days after the Wenchuan earthquake, 44 healthy survivors were recruited and scanned on a 3T MR imaging system. The survivors were divided into two groups according to their self-rating anxiety scale (SAS) score, including the SAS(+) (SAS > 55 after correction) group and SAS(-) (SAS < 55 after correction) group. Thrity-two healthy volunteers were also recruited as control group before earthquake. Individual maps of fractional anisotropy (FA) were calculated and voxel-based analysis (VBA) was performed to allow the comparison between survivors and controls using ANCOVAs in SPM2. In addition, a correlation between SAS score and regional FA value was examined using Pearson's correlation analysis in SPSS 11.5. Compared with the healthy cohort, the whole group of 44 survivors showed significantly decreased FA values in the right prefrontal lobe, the parietal lobe, the basal ganglia, and the right parahippocampus. These effects did not appear to depend on self-rating anxiety. For the first time we provide evidence that acute trauma altered cerebral microstructure within the limbic system; furthermore, these alterations are evident shortly after the traumatic event, highlighting the need for early evaluation and intervention for trauma survivors. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.
Keywordstress depression PTSD earthquake MRI diffusion tensor imaging
Subject AreaTrauma Psychology,
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Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China [2007CB512305/2] ; National Natural Science Foundation [81030027, 30900361] ; Distinguished Young Scholars of Sichuan [2011JQ0005] ; Programs for New Century Excellent Talents in University [NCET-10-0596] ; American CMB
Project Intro.Contract grant sponsor: National Basic Research Program of China; Contract grant numbers: 973 Program 2007CB512305/2; Contract grant sponsor: National Natural Science Foundation; Contract grant numbers: 81030027 and 30900361; Contract grant sponsor: the Distinguished Young Scholars of Sichuan; Contract grant numbers: 2011JQ0005; Contract grant sponsor: the Programs for New Century Excellent Talents in University; Contract grant numbers: NCET-10-0596; Dr QY Gong also acknowledges the support from the American CMB Distinguished Professorship Award administered by the Institute of International Education, USA.
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000313115000010
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordWHITE-MATTER ; NEUROIMAGING EVIDENCE ; DISORDER ; ARCHITECTURE ; ACTIVATION ; DEPRESSION ; IMAGES ; MEMORY ; PTSD
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10846
Collection脑与认知科学国家重点实验室
Corresponding AuthorGong, QY (reprint author), Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China.
Affiliation1.Sichuan Univ, W China Hosp, Dept Radiol, Ctr Diagnost Imaging,HMRRC, Chengdu 610041, Peoples R China
2.Sichuan Univ, W China Hosp, State Key Lab Biotherapy, Dept Neurol & Psychiat, Chengdu 610041, Peoples R China
3.Univ Elect Sci & Technol China, Sch Sci & Technol, Brain Funct Lab, Chengdu 610054, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England
Recommended Citation
GB/T 7714
Chen, Long,Lui, Su,Wu, Qi-Zhu,et al. Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors[J]. HUMAN BRAIN MAPPING,2013,34(2):367-373.
APA Chen, Long.,Lui, Su.,Wu, Qi-Zhu.,Zhang, Wei.,Zhou, Dong.,...&Gong, QY .(2013).Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors.HUMAN BRAIN MAPPING,34(2),367-373.
MLA Chen, Long,et al."Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors".HUMAN BRAIN MAPPING 34.2(2013):367-373.
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