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A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings
Lui, Simon S. Y.1,2,3; Sham, Pak4; Chan, Raymond C. K.2; Cheung, Eric F. C.1; Cheung, EFC
2011-11-01
发表期刊CHINESE SCIENCE BULLETIN
ISSN1001-6538
文章类型Article
卷号56期号:32页码:3394-3397
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摘要The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.
关键词psychosis endophenotypes neuropsychology social cognition
学科领域变态心理学
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收录类别SCI ; SSCI
语种英语
项目资助者Project-Oriented Hundred Talents Programme [O7CX031003] ; Chinese Academy of Sciences [KSCX2-YW-R-131, KSCX2-EW-J-8] ; National Science Fund for Distinguished Young Scholars [81088001]
项目简介This work was supported by the Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8), a grant from the National Science Fund for Distinguished Young Scholars (81088001) to Raymond Chan.
WOS记录号WOS:000296641800007
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10850
专题中国科学院心理健康重点实验室
通讯作者Cheung, EFC
作者单位1.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China
4.Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
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Lui, Simon S. Y.,Sham, Pak,Chan, Raymond C. K.,et al. A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings[J]. CHINESE SCIENCE BULLETIN,2011,56(32):3394-3397.
APA Lui, Simon S. Y.,Sham, Pak,Chan, Raymond C. K.,Cheung, Eric F. C.,&Cheung, EFC.(2011).A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings.CHINESE SCIENCE BULLETIN,56(32),3394-3397.
MLA Lui, Simon S. Y.,et al."A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings".CHINESE SCIENCE BULLETIN 56.32(2011):3394-3397.
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