Institutional Repository of Key Laboratory of Mental Health, CAS
| A follow-up fMRI study of a transferable placebo anxiolytic effect | |
Zhang, Wencai1 ; Qin, Shaozheng3; Guo, Jianyou1; Luo, Jing1,2; Luo, J
| |
| Contribution Rank | 1 |
| Abstract | Our previous study showed that placebo expectations can develop in a transferable manner; for example, a placebo expectation developed within an analgesic experience may lead to reduced anxiety. Considering that activities in such emotion-responsive areas as the amygdala and insula can be detected through functional magnetic resonance imaging (fMRI), we used fMRI to further study the transferable placebo anxiolytic effect. A main-effect analysis showed that activity in the amygdala and insula was reduced in the placebo condition, whereas an interaction analysis showed activity in the two regions was selectively attenuated in the placebo condition when unpleasant pictures were viewed. We also observed greater activity in the subgenual anterior cingulate cortex under placebo conditions when either emotionally negative or neutral pictures were viewed. These data suggest that the anxiety-relieving placebo effect arose from a reward-related response underpinned by the participants' expectations. |
| Keyword | Placebo anxiolytic effect Expectation Negative emotion Amygdala Subgenual anterior cingulate cortex Functional magnetic resonance imaging (fMRI) |
| Subject Area | 健康心理学 |
| 2011-08-01 | |
| Language | 英语 |
| Source Publication | PSYCHOPHYSIOLOGY
 |
| ISSN | 0048-5772 |
| Volume | 48Issue:8Pages:1119-1128 |
| Subtype | Article |
| URL | 查看原文 |
| Indexed By | SCI ; SSCI |
| Project Intro. | This research was supported by the National Basic Research Program of China (Grant 2010CB833904), the National Natural Science Foundation of China (Grants 30970890 and 30770708), the National Hi-Tech Research and Development Program of China (Grants 2008AA022604 and 2009BAI77B06), the Young Scientists Fund of the Institute of Psychology (Grant Y0CX451S01), and the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant KSCX2-EW-J-8). |
| WOS ID | WOS:000292449900010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/10851 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | Luo, J |
| Affiliation | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Capital Normal Univ, Learning & Cognit Lab, Beijing, Peoples R China 3.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, NL-6525 ED Nijmegen, Netherlands |
| First Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | Zhang, Wencai,Qin, Shaozheng,Guo, Jianyou,et al. A follow-up fMRI study of a transferable placebo anxiolytic effect[J]. PSYCHOPHYSIOLOGY,2011,48(8):1119-1128. |
| APA | Zhang, Wencai,Qin, Shaozheng,Guo, Jianyou,Luo, Jing,&Luo, J.(2011).A follow-up fMRI study of a transferable placebo anxiolytic effect.PSYCHOPHYSIOLOGY,48(8),1119-1128. |
| MLA | Zhang, Wencai,et al."A follow-up fMRI study of a transferable placebo anxiolytic effect".PSYCHOPHYSIOLOGY 48.8(2011):1119-1128. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| WOS_000292449900010.（843KB） | 期刊论文 | 出版稿 | 限制开放 | Apache License | Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment