Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study

	Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study
	Liu, Chun-Hong 1; Li, Feng 2; Li, Su-Fang 3; Wang, Yong-Jun 2; Tie, Chang-Le 2; Wu, Hai-Yan3 ; Zhou, Zhen 4; Zhang, Dan 5; Dong, Jie 1; Yang, Zhi6 ; Wang, Chuan-Yue 2; Yang, Z (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
心理所单位排序	5
摘要	We examined resting state brain activity in the depressive phase of bipolar disorder (BD) by measuring the amplitude of low-frequency fluctuations (ALFF) in the functional magnetic resonance imaging (fMRI) signal. Unlike functional connectivity, the ALFF approach reflects local properties in specific regions and provides direct information about impaired foci. Groups of 26 patients with BD depression and 26 gender-, age-, and education-matched healthy subjects participated in fMRI scans. We examined group differences in ALFF findings as well as correlations between clinical measurements and ALFF in the regions showing significant group differences. Our results showed that patients with BD depression had significantly increased ALFF in the left insula, the right caudate nucleus, the temporal gyrus, the bilateral inferior frontal gyrus, and the posterior lobe of the cerebellum. They also had decreased ALFF in the left postcentral gyrus, the left parahippocampal gyrus, and the cerebellum. Moderate negative correlations were found between the Hamilton Depression Rating Scale score and ALFF in the left insular cortex in the patient group. These results support a model of BD that involves dysfunction in the prefrontal-limbic networks and associated striatal systems. We also demonstrated the feasibility of ALFF as a technique to investigate persistent cerebral dysfunction in BD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
关键词	Bipolar disorder Resting state fMRI Amplitude of low-frequency fluctuation
学科领域	Physiological Psychology/biological Psychology，medical Psychology
	2012-08-01
语种	英语
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN	0925-4927
卷号	203 期号:2-3 页码:175-179
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	The authors gratefully acknowledge Beijing Normal University Imaging Center for Brain Research and Prof. Yu-Feng Zang for their contributions in MRI data acquisition. This study was supported by grants from the 11th Five-Year Key Program for Science and Technology Development of China (grant no. 2007BAI17B05), the National Science Foundations of China (NSFC, grant no. 30900366), the Program for Science and Technology of Beijing (grant no. D101107047810001), the National Basic Research Program of China (grant no. 2007CB512300), and the Capital Medical University Fundamental and Clinical Foundations of China (grant no. 10JL63).
WOS记录号	WOS:000323316900009
资助机构	11th Five-Year Key Program for Science and Technology Development of China [2007BAI17B05] ; National Science Foundations of China (NSFC) [30900366] ; Program for Science and Technology of Beijing [D101107047810001] ; National Basic Research Program of China [2007CB512300] ; Capital Medical University Fundamental and Clinical Foundations of China [10JL63]
引用统计	被引频次：104[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10858
专题	中国科学院行为科学重点实验室
通讯作者	Yang, Z (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China.
作者单位	1.Capital Med Univ, Beijing Anding Hosp, Dept Radiol, Beijing 100088, Peoples R China 2.Capital Med Univ, Beijing Anding Hosp, Lab Clin Psychopharmacol, Beijing 100088, Peoples R China 3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 4.Capital Med Univ, Dept Biomed Engn, Beijing 100069, Peoples R China 5.Capital Med Univ, Fu Xing Hosp, Dept Ultrasound, Beijing 100038, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Liu, Chun-Hong,Li, Feng,Li, Su-Fang,et al. Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2012,203(2-3):175-179.
APA	Liu, Chun-Hong.,Li, Feng.,Li, Su-Fang.,Wang, Yong-Jun.,Tie, Chang-Le.,...&Yang, Z .(2012).Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study.PSYCHIATRY RESEARCH-NEUROIMAGING,203(2-3),175-179.
MLA	Liu, Chun-Hong,et al."Abnormal baseline brain activity in bipolar depression: A resting state functional magnetic resonance imaging study".PSYCHIATRY RESEARCH-NEUROIMAGING 203.2-3(2012):175-179.

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