PSYCH OpenIR  > 中国科学院心理健康重点实验室
Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI
Wu, Qi-Zhu1; Li, Dong-Ming1; Kuang, Wei-Hong2; Zhang, Ti-Jiang1; Lui, Su1; Huang, Xiao-Qi1; Chan, Raymond C. K.3,4; Kemp, Graham J.5; Gong, Qi-Yong1,5; Gong, QY (reprint author), Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China.
2011-08-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号32期号:8页码:1290-1299
产权排序3
摘要Treatment-refractory depression (TRD) represents a large proportion of the depressive population, yet has seldom been investigated using advanced imaging techniques. To characterize brain dysfunction in TRD, we performed resting-state functional MRI (rs-fMRI) on 22 TRD patients, along with 26 matched healthy subjects and 22 patients who were depressed but not treatment-refractory (NDD) as comparison groups. Results were analyzed using a data-driven approach known as Regional Homogeneity (ReHo) analysis which measures the synchronization of spontaneous fMRI signal oscillations within spatially neighboring voxels. Relative to healthy controls, both depressed groups showed high ReHo primarily within temporo-limbic structures, and more widespread low ReHo in frontal, parietal, posterior fusiform cortices, and caudate. TRD patients showed more cerebral regions with altered ReHo than did NDD. Moderate but significant correlations between the altered regional ReHo and measures of clinical severity were observed in some identified clusters. These findings shed light on the pathophysiological mechanisms underlying TRD and demonstrate the feasibility of using ReHo as a research and clinical tool to monitor persistent cerebral dysfunction in depression, although further work is necessary to compare different measures of brain function to elucidate the neural substrates of these ReHo abnormalities. Hum Brain Mapp 32:1290-1299, 2011. (C) 2010 Wiley-Liss, Inc.
关键词treatment-refractory depression functional magnetic resonance imaging resting-state regional homogeneity major depressive disorder not-refractory MDD
学科领域Physiological Psychology/biological Psychology,medical Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [30625024, 30900362, 30900361, 30728017] ; China Postdoctoral Science Foundation [20080441209] ; National Basic Research Program (973) [2007CB512305/2] ; National High Technology Program of China (863) [2008AA02Z408]
项目简介Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 30625024, 30900362, 30900361, 30728017; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 20080441209; Contract grant sponsor: National Basic Research Program (973); Contract grant number: 2007CB512305/2; Contract grant sponsor: National High Technology Program of China (863); Contract grant number: 2008AA02Z408.
WOS记录号WOS:000293532100009
引用统计
被引频次:104[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10859
专题中国科学院心理健康重点实验室
通讯作者Gong, QY (reprint author), Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China.
作者单位1.Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China
2.Sichuan Univ, Dept Psychiat, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Univ Liverpool, Magnet Resonance & Image Anal Res Ctr MARIARC, Liverpool L69 3BX, Merseyside, England
推荐引用方式
GB/T 7714
Wu, Qi-Zhu,Li, Dong-Ming,Kuang, Wei-Hong,et al. Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI[J]. HUMAN BRAIN MAPPING,2011,32(8):1290-1299.
APA Wu, Qi-Zhu.,Li, Dong-Ming.,Kuang, Wei-Hong.,Zhang, Ti-Jiang.,Lui, Su.,...&Gong, QY .(2011).Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI.HUMAN BRAIN MAPPING,32(8),1290-1299.
MLA Wu, Qi-Zhu,et al."Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI".HUMAN BRAIN MAPPING 32.8(2011):1290-1299.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000293532100009.p(299KB)期刊论文出版稿限制开放Apache License浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wu, Qi-Zhu]的文章
[Li, Dong-Ming]的文章
[Kuang, Wei-Hong]的文章
百度学术
百度学术中相似的文章
[Wu, Qi-Zhu]的文章
[Li, Dong-Ming]的文章
[Kuang, Wei-Hong]的文章
必应学术
必应学术中相似的文章
[Wu, Qi-Zhu]的文章
[Li, Dong-Ming]的文章
[Kuang, Wei-Hong]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000293532100009.pdf.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。