Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI

	Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI
	Wu, Qi-Zhu 1; Li, Dong-Ming 1; Kuang, Wei-Hong 2; Zhang, Ti-Jiang 1; Lui, Su 1; Huang, Xiao-Qi 1; Chan, Raymond C. K.3,4 ; Kemp, Graham J.5; Gong, Qi-Yong 1,5; Gong, QY (reprint author), Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China.
心理所单位排序	3
摘要	Treatment-refractory depression (TRD) represents a large proportion of the depressive population, yet has seldom been investigated using advanced imaging techniques. To characterize brain dysfunction in TRD, we performed resting-state functional MRI (rs-fMRI) on 22 TRD patients, along with 26 matched healthy subjects and 22 patients who were depressed but not treatment-refractory (NDD) as comparison groups. Results were analyzed using a data-driven approach known as Regional Homogeneity (ReHo) analysis which measures the synchronization of spontaneous fMRI signal oscillations within spatially neighboring voxels. Relative to healthy controls, both depressed groups showed high ReHo primarily within temporo-limbic structures, and more widespread low ReHo in frontal, parietal, posterior fusiform cortices, and caudate. TRD patients showed more cerebral regions with altered ReHo than did NDD. Moderate but significant correlations between the altered regional ReHo and measures of clinical severity were observed in some identified clusters. These findings shed light on the pathophysiological mechanisms underlying TRD and demonstrate the feasibility of using ReHo as a research and clinical tool to monitor persistent cerebral dysfunction in depression, although further work is necessary to compare different measures of brain function to elucidate the neural substrates of these ReHo abnormalities. Hum Brain Mapp 32:1290-1299, 2011. (C) 2010 Wiley-Liss, Inc.
关键词	treatment-refractory depression functional magnetic resonance imaging resting-state regional homogeneity major depressive disorder not-refractory MDD
学科领域	Physiological Psychology/biological Psychology，medical Psychology
	2011-08-01
语种	英语
发表期刊	HUMAN BRAIN MAPPING
ISSN	1065-9471
卷号	32 期号:8 页码:1290-1299
期刊论文类型	Article
URL	查看原文
收录类别	SCI
项目简介	Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 30625024, 30900362, 30900361, 30728017; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 20080441209; Contract grant sponsor: National Basic Research Program (973); Contract grant number: 2007CB512305/2; Contract grant sponsor: National High Technology Program of China (863); Contract grant number: 2008AA02Z408.
WOS记录号	WOS:000293532100009
资助机构	National Natural Science Foundation of China [30625024, 30900362, 30900361, 30728017] ; China Postdoctoral Science Foundation [20080441209] ; National Basic Research Program (973) [2007CB512305/2] ; National High Technology Program of China (863) [2008AA02Z408]
引用统计	被引频次：168[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/10859
专题	中国科学院心理健康重点实验室
通讯作者	Gong, QY (reprint author), Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China.
作者单位	1.Sichuan Univ, Huaxi MR Res Ctr HMRRC, Dept Radiol, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China 2.Sichuan Univ, Dept Psychiat, State Key Lab Biotherapy, W China Hosp, Chengdu 610041, Sichuan Prov, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Univ Liverpool, Magnet Resonance & Image Anal Res Ctr MARIARC, Liverpool L69 3BX, Merseyside, England
推荐引用方式 GB/T 7714	Wu, Qi-Zhu,Li, Dong-Ming,Kuang, Wei-Hong,et al. Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI[J]. HUMAN BRAIN MAPPING,2011,32(8):1290-1299.
APA	Wu, Qi-Zhu.,Li, Dong-Ming.,Kuang, Wei-Hong.,Zhang, Ti-Jiang.,Lui, Su.,...&Gong, QY .(2011).Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI.HUMAN BRAIN MAPPING,32(8),1290-1299.
MLA	Wu, Qi-Zhu,et al."Abnormal Regional Spontaneous Neural Activity in Treatment-Refractory Depression Revealed by Resting-State fMRI".HUMAN BRAIN MAPPING 32.8(2011):1290-1299.

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