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Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder
Zhang, Tijiang2,3; Wang, Jinhui1; Yang, Yanchun4; Wu, Qizhu2; Li, Bin4; Chen, Long2; Yue, Qiang2; Tang, Hehan2; Yan, Chaogan1; Lui, Su; Huang, Xiaoqi2; Chan, Raymond C. K.5,6; Zang, Yufeng1; He, Yong1; Gong, Qiyong2,7; He, Y (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
2011
发表期刊JOURNAL OF PSYCHIATRY & NEUROSCIENCE
ISSN1180-4882
文章类型Article
卷号36期号:1页码:23-31
产权排序5
摘要Background: Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disorder that is characterized by recurrent intrusive thoughts, ideas or images and repetitive ritualistic behaviours. Although focal structural and functional abnormalities in specific brain regions have been widely studied in populations with OCD, changes in the functional relations among them remain poorly understood. This study examined OCD-related alterations in functional connectivity patterns in the brain's top-down control network. Methods: We applied resting-state functional magnetic resonance imaging to investigate the correlation patterns of intrinsic or spontaneous blood oxygen level-dependent signal fluctuations in 18 patients with OCD and 16 healthy controls. The brain control networks were first constructed by thresholding temporal correlation matrices of 39 brain regions associated with top-down control and then analyzed using graph theory-based approaches. Results: Compared with healthy controls, the patients with OCD showed decreased functional connectivity in the posterior temporal regions and increased connectivity in various control regions such as the cingulate, precuneus, thalamus and cerebellum. Furthermore, the brain's control networks in the healthy controls showed small-world architecture (high clustering coefficients and short path lengths), suggesting an optimal balance between modularized and distributed information processing. In contrast, the patients with OCD showed significantly higher local clustering, implying abnormal functional organization in the control network. Further analysis revealed that the changes in network properties occurred in regions of increased functional connectivity strength in patients with OCD. Limitations: The patient group in the present study was heterogeneous in terms of symptom clusters, and most of the patients with OCD were medicated. Conclusion: Our preliminary results suggest that the organizational patterns of intrinsic brain activity in the control networks are altered in patients with OCD and thus provide empirical evidence for aberrant functional connectivity in the large-scale brain systems in people with this disorder.
学科领域Health Psychology,network Psychology
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收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China [30625024, 81030027, 81030028, 30870667, 30728017, 30960099] ; National Basic Research Program (973 Program) [2007CB512305/2] ; National High Technology Program of China (863 Program) [2008AA02Z408]
项目简介This study was supported by National Natural Science Foundation of China (Grant Nos. 30625024, 81030027, 81030028, 30870667, 30728017 and 30960099), National Basic Research Program (973 Program No: 2007CB512305/2) and National High Technology Program of China (863 Program No: 2008AA02Z408). We thank Zhang John Chen for English editing and proofreading. Dr. Gong also acknowledges his appointment as an Honorary Fellow of the Faculty of Medicine, University of Liverpool, Liverpool, United Kingdom.
WOS记录号WOS:000285461300004
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被引频次:76[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10860
专题中国科学院心理健康重点实验室
通讯作者He, Y (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Sichuan Univ, W China Hosp, Dept Radiol, HMRRC, Chengdu 610064, Peoples R China
3.Affiliated Hosp, Zunyi Med Coll, Dept Radiol, Zunyi, Peoples R China
4.Sichuan Univ, Dept Psychiat, State Key Lab Biotherapy, W China Hosp, Chengdu 610064, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
7.Univ Liverpool, Fac Med, Div Med Imaging, Liverpool L69 3BX, Merseyside, England
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Zhang, Tijiang,Wang, Jinhui,Yang, Yanchun,et al. Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2011,36(1):23-31.
APA Zhang, Tijiang.,Wang, Jinhui.,Yang, Yanchun.,Wu, Qizhu.,Li, Bin.,...&He, Y .(2011).Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder.JOURNAL OF PSYCHIATRY & NEUROSCIENCE,36(1),23-31.
MLA Zhang, Tijiang,et al."Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 36.1(2011):23-31.
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