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Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study
Yang, Hong2; Wu, Qi-Zhu1; Guo, Lan-Ting3; Li, Qian-Qian3; Long, Xiang-Yu4; Huang, Xiao-Qi1; Chan, Raymond C. K.5; Gong, Qi-Yong1; Gong, QY (reprint author), Sichuan Univ, W China Hosp, Ctr Med Imaging, Dept Radiol,HMRRC, Chengdu 610041, Sichuan, Peoples R China.
2011-09-15
发表期刊NEUROSCIENCE LETTERS
ISSN0304-3940
文章类型Article
卷号502期号:2页码:89-93
产权排序5
摘要Abnormal baseline brain functional connectivity in attention-deficit/hyperactivity disorder (ADHD) has been revealed in a number of studies by using resting-state functional MRI (rfMRI). The aim of this study was to investigate the spontaneous frontal activities in medication-nave ADHD boys using the rfMRI derived index, amplitude of low-frequency fluctuation (ALFF). In total 17 ADHD boys and 17 matched controls were recruited to undergo rfMRI scan on a 3.0 T MRI system. For each subject, six oblique slices covering the frontal areas were acquired with a rapid sampling rate (TR = 400 ms). Functional images were processed in AFNI for calculation of ALFF and then group comparison was performed using voxel-based t-test. With a corrected threshold of p < 0.05 determined by AlphaSim, we found that in comparison with controls, ADHD patients demonstrated higher ALFF values in the left superior frontal gyrus and sensorimotor cortex (SMC), and lower ALFF values in the bilateral anterior, middle cingulate and the right middle frontal gyrus (MFG). Significant correlations were found between patients' WSCT measures and the peak ALFF located in the right MFG (r = 0.69, p = 0.02), and the left SMC (r = 0.65, p = 0.03). Our results revealed abnormal frontal activities at resting state associated with underlying physiopathology of ADHD, and suggested the ALFF analysis to be a potential approach in further exploration of this disorder. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
关键词Attention-deficit/hyperactivity disorder Resting-state fMRI Spontaneous brain activity
学科领域Developmental Psychology,physiological Psychology/biological Psychology
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收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [81030027, 30900362, 30971043] ; National Basic Research Program (973) [2007CB512305/2]
项目简介This study was supported by the National Natural Science Foundation of China (Nos. 81030027, 30900362 and 30971043), National Basic Research Program (973 No. 2007CB512305/2). The funding sponsors have not been involved in the design, execution of the study, in the manuscript drafting and in the decision to submit the paper for publication.
WOS记录号WOS:000295314100005
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被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/10861
专题中国科学院心理健康重点实验室
通讯作者Gong, QY (reprint author), Sichuan Univ, W China Hosp, Ctr Med Imaging, Dept Radiol,HMRRC, Chengdu 610041, Sichuan, Peoples R China.
作者单位1.Sichuan Univ, W China Hosp, Ctr Diagnost Imaging, Dept Radiol,HMRRC, Chengdu 610041, Sichuan, Peoples R China
2.Zhejiang Univ, Affiliated Hosp 1, Coll Med Sci, Dept Radiol, Hangzhou 310003, Zhejiang, Peoples R China
3.Sichuan Univ, W China Hosp, Dept Psychiat, Chengdu 610041, Sichuan, Peoples R China
4.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
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Yang, Hong,Wu, Qi-Zhu,Guo, Lan-Ting,et al. Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study[J]. NEUROSCIENCE LETTERS,2011,502(2):89-93.
APA Yang, Hong.,Wu, Qi-Zhu.,Guo, Lan-Ting.,Li, Qian-Qian.,Long, Xiang-Yu.,...&Gong, QY .(2011).Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study.NEUROSCIENCE LETTERS,502(2),89-93.
MLA Yang, Hong,et al."Abnormal spontaneous brain activity in medication-naive ADHD children: A resting state fMRI study".NEUROSCIENCE LETTERS 502.2(2011):89-93.
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