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Abnormal topological organization of structural brain networks in schizophrenia
Zhang, Yuanchao1,2; Lin, Lei2,8; Lin, Ching-Po3,4; Zhou, Yuan5; Chou, Kun-Hsien3; Lo, Chun-Yi3,4; Su, Tung-Ping6,7; Jiang, Tianzi1,2,9; Su, TP (reprint author), Taipei Vet Gen Hosp, Dept Psychiat, 201,Sec 2,Shih Pai Rd, Taipei 112, Taiwan.
2012-11-01
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
SubtypeArticle
Volume141Issue:2-3Pages:109-118
Contribution Rank5
AbstractSchizophrenia is a debilitating mental disorder characterized by disturbances of thought and emotion as well as neurocognitive deficits. It is hypothesized that the core symptoms of schizophrenia arise from the inability to integrate neural processes segregated across distributed brain regions. Graph theory allows us to verify this hypothesis at large-scale structural network level. In this study, a sample of 101 schizophrenic patients and 101 healthy controls was included. We sought to investigate the abnormality of network topological organization in patients with schizophrenia by using the cortical thickness measurement from magnetic resonance imaging. Brain networks were constructed by thresholding cortical thickness correlation matrices of 78 regions and analyzed using graph theoretical approaches. Compared to healthy controls, patients showed increased characteristic path length and clustering coefficient in the structural cortical networks. Moreover, schizophrenia patients were associated with reduced nodal centrality in several regions of the default network and increased nodal centrality mainly in primary cortex and paralimbic cortex regions. These findings suggest that the structural networks of schizophrenic patients have a less optimal topological organization, resulting in reduced capacity to integrate information across brain regions. (C) 2012 Elsevier B.V. All rights reserved.
KeywordSchizophrenia Structural network Cortical thickness Topological organization Betweenness centrality
Subject AreaAbnormal Psychology,physiological Psychology/biological Psychology
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Indexed BySSCI
Language英语
Funding OrganizationMRI Core Laboratory of National Yang-Ming University ; Ministry of Education of Taiwan (Aim for the Top University Plan) ; National Key Basic Research and Development Program (973) [2011CB707800] ; Natural Science Foundation of China [91132301, 81101000, 30900487] ; Fundamental Research Funds for the Central Universities [ZYGX2011J098] ; National Science Council of Taiwan [NSC 98-2517-S-004-001-MY3, 98-2627-B-010-008, NSC 98-2627-B-010-008-MY3] ; National Health Research Institute [NHRI-EX98-9813EC] ; Academia Sinica [AS-99-TP-AC1]
Project Intro.The authors also acknowledge MR support from the MRI Core Laboratory of National Yang-Ming University that was funded by the Ministry of Education of Taiwan (Aim for the Top University Plan). This work was partially supported by the National Key Basic Research and Development Program (973) (grant no. 2011CB707800), the Natural Science Foundation of China (grant no. 91132301, no. 81101000 and no. 30900487), the Fundamental Research Funds for the Central Universities (grant no. ZYGX2011J098), the National Science Council of Taiwan (NSC 98-2517-S-004-001-MY3, 98-2627-B-010-008, NSC 98-2627-B-010-008-MY3), the National Health Research Institute (NHRI-EX98-9813EC) and the Academia Sinica (AS-99-TP-AC1).
WOS IDWOS:000309511300001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10862
Collection中国科学院行为科学重点实验室
Corresponding AuthorSu, TP (reprint author), Taipei Vet Gen Hosp, Dept Psychiat, 201,Sec 2,Shih Pai Rd, Taipei 112, Taiwan.
Affiliation1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
3.Natl Yang Ming Univ, Inst Neurosci, Brain Connect Lab, Taipei 112, Taiwan
4.Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan
5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100190, Peoples R China
6.Taipei Vet Gen Hosp, Dept Psychiat, Taipei 112, Taiwan
7.Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan
8.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China
9.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Zhang, Yuanchao,Lin, Lei,Lin, Ching-Po,et al. Abnormal topological organization of structural brain networks in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2012,141(2-3):109-118.
APA Zhang, Yuanchao.,Lin, Lei.,Lin, Ching-Po.,Zhou, Yuan.,Chou, Kun-Hsien.,...&Su, TP .(2012).Abnormal topological organization of structural brain networks in schizophrenia.SCHIZOPHRENIA RESEARCH,141(2-3),109-118.
MLA Zhang, Yuanchao,et al."Abnormal topological organization of structural brain networks in schizophrenia".SCHIZOPHRENIA RESEARCH 141.2-3(2012):109-118.
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