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Adaptive influence of long term high altitude residence on spatial working memory: An fMRI study
Yan, Xiaodan2,3,4; Zhang, Jiaxing1,2; Gong, Qiyong5; Weng, Xuchu2; Zhang, JX (reprint author), Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China.
2011-10-01
Source PublicationBRAIN AND COGNITION
ISSN0278-2626
SubtypeArticle
Volume77Issue:1Pages:53-59
Contribution Rank1
AbstractWith an increasing population living at a high altitude (HA), the impact of HA residence on human cognitive function has raised concerns. We recruited two groups of college students with one group born and grew up at HA until early adulthood and the control group born and grew up at near sea level (SL); the two groups were matched at age, gender ratio, educational level, the ancestral lines, and peripheral physiology (especially the hemoglobin concentration). A 2-back spatial working memory task was performed by each subject in the scanner while fMRI data were acquired. Compared to the SL control group, the HA group showed equal response accuracy, with more variance in reaction time and a larger average value. fMRI data indicated that both groups showed common activation patterns in the neural pathway typically associated with working memory. The HA group had greater activation at the left pyramis, the left superior temporal gyrus and less activation at the left middle occipital gyrus. Significant correlations were found within each group between the reaction times and BOLD signal change amplitudes at the frontal cortex and the precentral cortex. (C) 2011 Elsevier Inc. All rights reserved.
KeywordSpatial working memory n-Back fMRI Compensation
Subject AreaCognitive Psychology,environmental Psychology
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Indexed BySCI ; SSCI
Language英语
WOS IDWOS:000294378000008
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/10864
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, JX (reprint author), Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China.
Affiliation1.Xiamen Univ, Dept Physiol, Coll Med, Xiamen, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing 100101, Peoples R China
3.Rensselaer Polytech Inst, Dept Cognit Sci, Troy, NY USA
4.NYU, Ctr Biomed Imaging, New York, NY USA
5.Sichuan Univ, W China Hosp, Huaxi Magnet Resonance Res Ctr, Chengdu 610064, Peoples R China
Recommended Citation
GB/T 7714
Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,et al. Adaptive influence of long term high altitude residence on spatial working memory: An fMRI study[J]. BRAIN AND COGNITION,2011,77(1):53-59.
APA Yan, Xiaodan,Zhang, Jiaxing,Gong, Qiyong,Weng, Xuchu,&Zhang, JX .(2011).Adaptive influence of long term high altitude residence on spatial working memory: An fMRI study.BRAIN AND COGNITION,77(1),53-59.
MLA Yan, Xiaodan,et al."Adaptive influence of long term high altitude residence on spatial working memory: An fMRI study".BRAIN AND COGNITION 77.1(2011):53-59.
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