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Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis
Qian, Gui-min2; Pan, Guo-Feng3; Guo, Jian-You1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012
发表期刊NATURAL PRODUCT RESEARCH
ISSN1478-6419
文章类型Article
卷号26期号:24页码:2358-2362
产权排序3
摘要The anti-inflammatory and antinociceptive activities of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, were studied. The effects of cordymin on cytokine levels and total antioxidant activity were analysed. The antinociceptive effects of cordymin in vivo and in vitro were also determined. Cordymin treatment decreased the levels of tumour necrosis factor alpha, interleukin 1 beta and total antioxidant status. Cordymin inhibited the acetic acid-induced abdominal constrictions in mice in a dose-dependent manner. In the hot-plate test, results showed that cordymin significantly inhibited the reaction time to thermal stimuli at 30, 60 and 90 min. In neurolysin inhibition assay, cordymin showed strong activities against neurolysin (IC50 = 0.1 mu M). Our results show that cordymin is a potent anti-inflammatory and analgesic medicine.
关键词cordymin anti-inflammatory antinociceptive TNF-alpha IL-1 beta TAOS neurolysin
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者NNSF [30800301, 31170992] ; Ministry of Science and Technology [2010ZX09102-201-018] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
项目简介This project was supported by NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS记录号WOS:000310608200013
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11405
专题中国科学院心理健康重点实验室
通讯作者Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, Ningbo 315100, Zhejiang, Peoples R China
3.Capital Med Univ, Beijing Shijitan Hosp, Dept Tradit Chinese Med, Beijing 100038, Peoples R China
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Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,et al. Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2358-2362.
APA Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,&Guo, JY .(2012).Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis.NATURAL PRODUCT RESEARCH,26(24),2358-2362.
MLA Qian, Gui-min,et al."Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis".NATURAL PRODUCT RESEARCH 26.24(2012):2358-2362.
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