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Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis
Qian, Gui-min2; Pan, Guo-Feng3; Guo, Jian-You1; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
SubtypeArticle
Volume26Issue:24Pages:2358-2362
Contribution Rank3
AbstractThe anti-inflammatory and antinociceptive activities of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, were studied. The effects of cordymin on cytokine levels and total antioxidant activity were analysed. The antinociceptive effects of cordymin in vivo and in vitro were also determined. Cordymin treatment decreased the levels of tumour necrosis factor alpha, interleukin 1 beta and total antioxidant status. Cordymin inhibited the acetic acid-induced abdominal constrictions in mice in a dose-dependent manner. In the hot-plate test, results showed that cordymin significantly inhibited the reaction time to thermal stimuli at 30, 60 and 90 min. In neurolysin inhibition assay, cordymin showed strong activities against neurolysin (IC50 = 0.1 mu M). Our results show that cordymin is a potent anti-inflammatory and analgesic medicine.
Keywordcordymin anti-inflammatory antinociceptive TNF-alpha IL-1 beta TAOS neurolysin
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNNSF [30800301, 31170992] ; Ministry of Science and Technology [2010ZX09102-201-018] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
Project Intro.This project was supported by NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS IDWOS:000310608200013
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11405
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Zhejiang Pharmaceut Coll, Dept Tradit Chinese Med, Ningbo 315100, Zhejiang, Peoples R China
3.Capital Med Univ, Beijing Shijitan Hosp, Dept Tradit Chinese Med, Beijing 100038, Peoples R China
Recommended Citation
GB/T 7714
Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,et al. Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2358-2362.
APA Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,&Guo, JY .(2012).Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis.NATURAL PRODUCT RESEARCH,26(24),2358-2362.
MLA Qian, Gui-min,et al."Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis".NATURAL PRODUCT RESEARCH 26.24(2012):2358-2362.
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