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Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers
Zhang, Xiang Yang1,2,3; Chen, Da Chun3; Xiu, Mei Hong3; Hui, Li3; Liu, Haibo3; Luo, Xingguang4; Zuo, Lingjun4; Zhang, Huiping4; Kosten, Therese A.2; Kosten, Thomas R.2,3; Zhang, XY (reprint author), VA Med Ctr, Res Bldg 109,Room 130,2002 Holcombe Blvd, Houston, TX 77030 USA.
2012-10-01
发表期刊SCHIZOPHRENIA RESEARCH
ISSN0920-9964
文章类型Article
卷号141期号:1页码:48-53
产权排序1
摘要Recent evidence suggests that a dopamine beta-hydroxylase (DBH) polymorphism may play a role in determining an individual's predisposition to developing nicotine dependence. The mechanism for such an association may reflect nicotine's mediation of drug reward in the brain through actions on dopamine, a key mediator of drug reward. Because schizophrenia patients have usually high rates of nicotine use, they are a model group to study such an association. In this study, we hypothesized that the functional polymorphism of DBH (D beta H5'-Ins/Del) was associated with smoking in patients with schizophrenia. This polymorphism was genotyped in 636 chronic male schizophrenia (smoker/nonsmoker=490/146) and 396 male controls (smoker/nonsmoker=231/165) using a case-control design. The cigarettes smoked per day (CPD) and smoking behaviors were evaluated by clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND). The results showed no significant differences in DBH 5'-Ins/Del genotype and allele distributions between the patients and healthy controls or between smokers and nonsmokers in either patients or healthy controls alone. However, schizophrenic smokers with the Del allele smoked fewer cigarettes each day and had lower FTND score than those with Ins/Ins genotype. These results suggest that the DBH 5'-Ins/Del polymorphism may influence smoking severity among schizophrenic smokers. (C) 2012 Elsevier B.V. All rights reserved.
关键词Schizophrenia Dopamine beta-hydroxylase Smoking Nicotine Genotype Association
学科领域Abnormal Psychology,social Psychology
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收录类别SSCI
语种英语
项目资助者Stanley Medical Research Institute [03T-459, 05T-726] ; Department of Veterans Affairs [VISN 16] ; Mental Illness Research, Education and Clinical Center (MIRECC) ; United States National Institute of Health [P50-DA18827, K05-DA0454, U01-MH79639]
项目简介Funding for this study was provided by grants from the Stanley Medical Research Institute (03T-459 and 05T-726), and the Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health K05-DA0454, P50-DA18827 and U01-MH79639. These sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
WOS记录号WOS:000308709100009
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11413
专题中国科学院行为科学重点实验室
通讯作者Zhang, XY (reprint author), VA Med Ctr, Res Bldg 109,Room 130,2002 Holcombe Blvd, Houston, TX 77030 USA.
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Peking Univ, Ctr Biol Psychiat, Beijing HuiLongGuan Hosp, Beijing 100871, Peoples R China
4.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
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Zhang, Xiang Yang,Chen, Da Chun,Xiu, Mei Hong,et al. Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers[J]. SCHIZOPHRENIA RESEARCH,2012,141(1):48-53.
APA Zhang, Xiang Yang.,Chen, Da Chun.,Xiu, Mei Hong.,Hui, Li.,Liu, Haibo.,...&Zhang, XY .(2012).Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers.SCHIZOPHRENIA RESEARCH,141(1),48-53.
MLA Zhang, Xiang Yang,et al."Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers".SCHIZOPHRENIA RESEARCH 141.1(2012):48-53.
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