Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction

	Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction
	Levran, Orna; Peles, Einat; Randesi, Matthew; Shu, Xu; Ott, Jurg; Shen, Pei-Hong; Adelson, Miriam; Kreek, Mary Jeanne; Levran, O (reprint author), Rockefeller Univ, Lab Biol Addicit Dis, New York, NY 10021 USA.
心理所单位排序	4
摘要	Aim: The interindividual variability in the dose required for effective methadone maintenance treatment (MMT) for opioid addiction may be influenced in part by genetic variations in genes encoding pharmacodynamic factors of methadone. This study was conducted to identify some of these variants. Materials & methods: This study focused on 11 genes encoding components of the opioidergic (OPRM1, POMC and ARRB2), the dopaminergic (ANKK1 and DRD2) and the glutamatergic pathways (GRIN1 and GRIN2A), as well as the neurotrophin system (NGFB, BDNF, NTRK1 and NTRK2). The study includes 227 Israeli patients undergoing stable MMT. Results: Out of the 110 variants analyzed, 12 SNPs (in BDNF, NTRK2, OPRM1, DRD2 and ANKK1) were associated with methadone dose (nominal p < 0.05). Of these SNPs, ANKK1 rs7118900 and DRD2 rs2283265 are known to affect gene expression. Logistic regression of five representative SNPs discriminated between individuals requiring a methadone dose of >120 mg/day and <120 mg/day (p = 0.019), and showed moderate sensitivity and specificity (AUC of 0.63 in receiver operating characteristic analysis). Conclusion: This data should stimulate further research on the potential influence and clinical significance of these variants on MMT. Original submitted 14 November 2012; Revision submitted 12 March 2013.
关键词	ANKK1 BDNF DRD2 methadone maintenance NTRK2 OPRM1 pharmacogenetics
学科领域	Physiological Psychology/biological Psychology，medical Psychology
	2013
语种	英语
发表期刊	PHARMACOGENOMICS
ISSN	0191-8869
卷号	14 期号:7 页码:755-768
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	Funding was provided by P60-05130 from NIDA (MJ Kreek), grant # 8 UL1 TR000043 from the National Center fir Research Resources and the National Center for Advancing Translational Sciences, NIH (pilot award, O Levran) and the Adelson Medical Research Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject watt or materials discussed in the manuscript apart from those disclosed.
WOS记录号	WOS:000318846100016
资助机构	NIDA [P60-05130] ; National Center fir Research Resources [8 UL1 TR000043] ; National Center for Advancing Translational Sciences, NIH ; Adelson Medical Research Foundation
引用统计	被引频次：38[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11414
专题	中国科学院心理健康重点实验室
通讯作者	Levran, O (reprint author), Rockefeller Univ, Lab Biol Addicit Dis, New York, NY 10021 USA.
推荐引用方式 GB/T 7714	Levran, Orna,Peles, Einat,Randesi, Matthew,et al. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction[J]. PHARMACOGENOMICS,2013,14(7):755-768.
APA	Levran, Orna.,Peles, Einat.,Randesi, Matthew.,Shu, Xu.,Ott, Jurg.,...&Levran, O .(2013).Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.PHARMACOGENOMICS,14(7),755-768.
MLA	Levran, Orna,et al."Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction".PHARMACOGENOMICS 14.7(2013):755-768.

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