PSYCH OpenIR  > 中国科学院心理健康重点实验室
Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction
Levran, Orna; Peles, Einat; Randesi, Matthew; Shu, Xu; Ott, Jurg; Shen, Pei-Hong; Adelson, Miriam; Kreek, Mary Jeanne; Levran, O (reprint author), Rockefeller Univ, Lab Biol Addicit Dis, New York, NY 10021 USA.
2013
发表期刊PHARMACOGENOMICS
ISSN0191-8869
文章类型期刊论文
卷号14期号:7页码:755-768
产权排序4
摘要Aim: The interindividual variability in the dose required for effective methadone maintenance treatment (MMT) for opioid addiction may be influenced in part by genetic variations in genes encoding pharmacodynamic factors of methadone. This study was conducted to identify some of these variants. Materials & methods: This study focused on 11 genes encoding components of the opioidergic (OPRM1, POMC and ARRB2), the dopaminergic (ANKK1 and DRD2) and the glutamatergic pathways (GRIN1 and GRIN2A), as well as the neurotrophin system (NGFB, BDNF, NTRK1 and NTRK2). The study includes 227 Israeli patients undergoing stable MMT. Results: Out of the 110 variants analyzed, 12 SNPs (in BDNF, NTRK2, OPRM1, DRD2 and ANKK1) were associated with methadone dose (nominal p < 0.05). Of these SNPs, ANKK1 rs7118900 and DRD2 rs2283265 are known to affect gene expression. Logistic regression of five representative SNPs discriminated between individuals requiring a methadone dose of >120 mg/day and <120 mg/day (p = 0.019), and showed moderate sensitivity and specificity (AUC of 0.63 in receiver operating characteristic analysis). Conclusion: This data should stimulate further research on the potential influence and clinical significance of these variants on MMT. Original submitted 14 November 2012; Revision submitted 12 March 2013.
关键词ANKK1 BDNF DRD2 methadone maintenance NTRK2 OPRM1 pharmacogenetics
学科领域Physiological Psychology/biological Psychology,medical Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者NIDA [P60-05130] ; National Center fir Research Resources [8 UL1 TR000043] ; National Center for Advancing Translational Sciences, NIH ; Adelson Medical Research Foundation
项目简介Funding was provided by P60-05130 from NIDA (MJ Kreek), grant # 8 UL1 TR000043 from the National Center fir Research Resources and the National Center for Advancing Translational Sciences, NIH (pilot award, O Levran) and the Adelson Medical Research Foundation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject watt or materials discussed in the manuscript apart from those disclosed.
WOS记录号WOS:000318846100016
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11414
专题中国科学院心理健康重点实验室
通讯作者Levran, O (reprint author), Rockefeller Univ, Lab Biol Addicit Dis, New York, NY 10021 USA.
推荐引用方式
GB/T 7714
Levran, Orna,Peles, Einat,Randesi, Matthew,et al. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction[J]. PHARMACOGENOMICS,2013,14(7):755-768.
APA Levran, Orna.,Peles, Einat.,Randesi, Matthew.,Shu, Xu.,Ott, Jurg.,...&Levran, O .(2013).Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction.PHARMACOGENOMICS,14(7),755-768.
MLA Levran, Orna,et al."Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction".PHARMACOGENOMICS 14.7(2013):755-768.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000318846100016.p(369KB) 限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Levran, Orna]的文章
[Peles, Einat]的文章
[Randesi, Matthew]的文章
百度学术
百度学术中相似的文章
[Levran, Orna]的文章
[Peles, Einat]的文章
[Randesi, Matthew]的文章
必应学术
必应学术中相似的文章
[Levran, Orna]的文章
[Peles, Einat]的文章
[Randesi, Matthew]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000318846100016.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。