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Association of Polymorphisms of the Mu Opioid Receptor Gene with the Severity of HIV Infection and Response to HIV Treatment
Proudnikov, Dmitri; Randesi, Matthew; Levran, Orna; Crystal, Howard; Dorn, Magdalena; Ott, Jurg; Ho, Ann; Kreek, Mary Jeanne; Proudnikov, D (reprint author), Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave,Box 171, New York, NY 10065 USA.
2012
Source PublicationJOURNAL OF INFECTIOUS DISEASES
ISSN1389-4978
Subtype期刊论文
Volume205Issue:11Pages:1745-1756
Contribution Rank3
AbstractMu opioid receptor (OPRM1) ligands may alter expression of chemokines and chemokine receptors involved in penetration of human immunodeficiency virus (HIV) type 1 into the cell. We suggest that OPRM1 variants may affect the pathophysiology of HIV infection. DNA samples from 1031 eligible African Americans, Hispanics, and whites from the Women's Interagency HIV Study (WIHS) who were alive as of April 2006 were analyzed. We performed regression analysis of association of 18 OPRM1 variants with a change of viral load and CD4 cell count during 2 periods: between admission to WIHS and the start of highly active antiretroviral therapy (HAART) (interval X) and between the start of HAART and the most recent WIHS visit (interval Y), and examined the association of these variants with HIV status. Regardless of genotype, a significant decrease in viral load during interval X was found for each ethnicity. Whites with allele G of the functional polymorphism 118A > G (reference sequence rs1799971) showed a smaller decrease in viral load; those bearing minor alleles IVS1 + 1050A, IVS1 + 14123A, and IVS2 + 31A showed a larger decrease in viral load over interval X (0.01 < P < .05). Hispanics with the same alleles showed a greater increase in CD4 cell count over interval Y (0.01 < P < .05). We found an association between OPRM1 variants and HIV status in African Americans and whites. OPRM1 polymorphisms may alter the severity of HIV infection before and after HAART.
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNIH [P60 DA05130, MH79880, MH076537] ; National Natural Science Foundation of China [NSFC 30730057] ; National Institute of Allergy and Infectious Diseases (NIAID) [U01 318345, UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590] ; Eunice Kennedy Shriver National Institute of Child Health and Human Development [UO1-HD-32632] ; National Cancer Institute ; National Institute on Drug Abuse ; National Institute on Deafness and Other Communication Disorders ; National Center for Research Resources (UCSF-CTSI) [UL1 RR024131]
Project Intro.This work was supported by the NIH (grants P60 DA05130 and MH79880 to M. J. K. and grant MH076537 to H. C.) and the National Natural Science Foundation of China (grant NSFC 30730057 to J. O.).The WIHS project is supported in part by the National Institute of Allergy and Infectious Diseases (NIAID; grant U01 318345). Data in this manuscript were collected by the WIHS Collaborative Study Group, located at the New York City/Bronx Consortium (principal investigator, Kathryn Anastos); in Brooklyn, NY (Howard Minkoff); at the Washington, DC, Metropolitan Consortium (Mary Young); at the Connie Wofsy Study Consortium of Northern California (Ruth Greenblatt); at the Los Angeles County/Southern California Consortium (Alexandra Levine); at the Chicago Consortium (Mardge Cohen); and at the Data Coordinating Center (Stephen Gange). The WIHS is funded by the NIAID (grants UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, and UO1-AI-42590) and by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant UO1-HD-32632). The study is cofunded by the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute on Deafness and Other Communication Disorders. Funding is also provided by the National Center for Research Resources (UCSF-CTSI grant UL1 RR024131).
WOS IDWOS:000304065600020
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Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11415
Collection中国科学院心理健康重点实验室
Corresponding AuthorProudnikov, D (reprint author), Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave,Box 171, New York, NY 10065 USA.
Recommended Citation
GB/T 7714
Proudnikov, Dmitri,Randesi, Matthew,Levran, Orna,et al. Association of Polymorphisms of the Mu Opioid Receptor Gene with the Severity of HIV Infection and Response to HIV Treatment[J]. JOURNAL OF INFECTIOUS DISEASES,2012,205(11):1745-1756.
APA Proudnikov, Dmitri.,Randesi, Matthew.,Levran, Orna.,Crystal, Howard.,Dorn, Magdalena.,...&Proudnikov, D .(2012).Association of Polymorphisms of the Mu Opioid Receptor Gene with the Severity of HIV Infection and Response to HIV Treatment.JOURNAL OF INFECTIOUS DISEASES,205(11),1745-1756.
MLA Proudnikov, Dmitri,et al."Association of Polymorphisms of the Mu Opioid Receptor Gene with the Severity of HIV Infection and Response to HIV Treatment".JOURNAL OF INFECTIOUS DISEASES 205.11(2012):1745-1756.
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