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| Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats | |
Han, Xiao1; Wang, Weiwen2 ; Xue, Xiaofang1; Shao, Feng1; Li, Nanxin1,3; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
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| 心理所单位排序 | 2 |
| 摘要 | Isolation rearing produces significant behavioral and neurochemical dysregulations in rodents. However, few studies have examined the effects of short-term isolation rearing during puberty compared to chronic social isolation from weaning to adulthood. In this study, we subjected weaning rats to a brief two-week social isolation and then re-socialized them until adulthood. We found that early isolation rearing affected reversal learning without interfering with spatial learning in the Morris water maze. We also found that brain-derived neurotrophic factor (BDNF) protein expression was increased in the medial prefrontal cortex (mPFC) but was decreased in the nucleus accumbens (NAc), CA1 and dentate gyrus of the hippocampus in isolation-reared rats. Together, our findings support the use of adolescent social isolation as a rodent model to study brain and behavior abnormalities induced by early environmental interruptions. (C) 2011 Elsevier Inc. All rights reserved. |
| 关键词 | Adolescence BDNF Hippocampus Morris water maze Nucleus accumbens Prefrontal cortex Reversal learning Social isolation |
| 学科领域 | Health Psychology |
| 2011-10-10 | |
| 语种 | 英语 |
| 发表期刊 | BRAIN RESEARCH BULLETIN
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| ISSN | 0361-9230 |
| 卷号 | 86期号:3-4页码:173-178 |
| 期刊论文类型 | Article |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the National Natural of Science Foundation of China (grant no. 31070910), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), a grant from the American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (09KF013001). |
| WOS记录号 | WOS:000296405000006 |
| 资助机构 | National Natural of Science Foundation of China [31070910] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [09KF013001] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/11427 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China. |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Yale Univ, Dept Psychol, New Haven, CT 06520 USA |
| 推荐引用方式 GB/T 7714 | Han, Xiao,Wang, Weiwen,Xue, Xiaofang,et al. Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats[J]. BRAIN RESEARCH BULLETIN,2011,86(3-4):173-178. |
| APA | Han, Xiao,Wang, Weiwen,Xue, Xiaofang,Shao, Feng,Li, Nanxin,&Shao, F .(2011).Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats.BRAIN RESEARCH BULLETIN,86(3-4),173-178. |
| MLA | Han, Xiao,et al."Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats".BRAIN RESEARCH BULLETIN 86.3-4(2011):173-178. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000296405000006.p（539KB） | 限制开放 | Apache License | 请求全文 | |||
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