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Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats
Han, Xiao1; Wang, Weiwen2; Xue, Xiaofang1; Shao, Feng1; Li, Nanxin1,3; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2011-10-10
发表期刊BRAIN RESEARCH BULLETIN
ISSN0361-9230
文章类型Article
卷号86期号:3-4页码:173-178
产权排序2
摘要Isolation rearing produces significant behavioral and neurochemical dysregulations in rodents. However, few studies have examined the effects of short-term isolation rearing during puberty compared to chronic social isolation from weaning to adulthood. In this study, we subjected weaning rats to a brief two-week social isolation and then re-socialized them until adulthood. We found that early isolation rearing affected reversal learning without interfering with spatial learning in the Morris water maze. We also found that brain-derived neurotrophic factor (BDNF) protein expression was increased in the medial prefrontal cortex (mPFC) but was decreased in the nucleus accumbens (NAc), CA1 and dentate gyrus of the hippocampus in isolation-reared rats. Together, our findings support the use of adolescent social isolation as a rodent model to study brain and behavior abnormalities induced by early environmental interruptions. (C) 2011 Elsevier Inc. All rights reserved.
关键词Adolescence BDNF Hippocampus Morris water maze Nucleus accumbens Prefrontal cortex Reversal learning Social isolation
学科领域Health Psychology
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收录类别SCI
语种英语
项目资助者National Natural of Science Foundation of China [31070910] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [09KF013001]
项目简介This work was supported by the National Natural of Science Foundation of China (grant no. 31070910), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), a grant from the American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (09KF013001).
WOS记录号WOS:000296405000006
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被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11427
专题中国科学院心理健康重点实验室
通讯作者Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Yale Univ, Dept Psychol, New Haven, CT 06520 USA
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Han, Xiao,Wang, Weiwen,Xue, Xiaofang,et al. Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats[J]. BRAIN RESEARCH BULLETIN,2011,86(3-4):173-178.
APA Han, Xiao,Wang, Weiwen,Xue, Xiaofang,Shao, Feng,Li, Nanxin,&Shao, F .(2011).Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats.BRAIN RESEARCH BULLETIN,86(3-4),173-178.
MLA Han, Xiao,et al."Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats".BRAIN RESEARCH BULLETIN 86.3-4(2011):173-178.
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