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Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study
Zhang, Xiang Yang1,2,3; Chen, Da Chun3; Xiu, Mei Hong3; Haile, Colin N.2; Sun, Hongqiang3,4; Lu, Lin4; Kosten, Therese A.2; Kosten, Thomas R.2,3; Zhang, XY (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
2012-05-03
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume7Issue:5
Contribution Rank1
AbstractSchizophrenic patients have higher smoking rates than the general population. Studies show that smoking may be a form of self-medication in an attempt to alleviate cognitive deficits in schizophrenic patients of European background. This study examined the relationships between smoking and cognitive deficits in Chinese schizophrenic patients, which have previously received little systemic study. We recruited 580 male chronic patients meeting DSM-IV criteria for schizophrenia and 175 male control subjects who were matched on age and education. The subjects completed a detailed cigarette smoking questionnaire, the Fagerstrom Test for Nicotine Dependence (FTND), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Patients also were rated on the Positive and Negative Symptom Scale (PANSS), the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES), and the Abnormal Involuntary Movement Scale (AIMS). All five RBANS subscales except for the Visuospatial/Constructional index showed significantly lower cognitive performance for schizophrenics than normal controls. The schizophrenic smokers scored lower than the schizophrenic nonsmokers on the RBANS total score and the Visuospatial/Constructional and Immediate Memory indices. Similarly, the control smokers scored lower than the control non-smokers on the RBANS total score and the Immediate Memory index. Also, the schizophrenic smokers consistently performed the poorest on the cognitive domains of the RBANS. Among the schizophrenic patients, smokers displayed significantly fewer negative symptoms than non-smokers. Using multivariate regression analysis the following variables were independently associated with the RBANS total score: years of education, PANSS negative symptom score, age at schizophrenia onset, and number of hospitalizations. Our results show that smoking is associated with significant cognitive impairment in both schizophrenic patients and normal controls, but the smokers with schizophrenia had a reduced level of negative symptoms, suggesting that the benefits of smoking for those with schizophrenia may be limited to certain aspects of a given clinical phenotype.
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationStanley Medical Research Institute [03T-459, 05T-726] ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), U.S. National Institute of Health [K05-DA0454, P50-DA18827, U01-MH79639]
Project Intro.This study was funded by the Stanley Medical Research Institute (03T-459 and 05T-726), and the Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), U.S. National Institute of Health K05-DA0454, P50-DA18827 and U01-MH79639. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS IDWOS:000305343400042
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11439
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, XY (reprint author), Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Peking Univ, Beijing HuiLongGuan Hosp, Beijing 100871, Peoples R China
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiang Yang,Chen, Da Chun,Xiu, Mei Hong,et al. Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study[J]. PLOS ONE,2012,7(5).
APA Zhang, Xiang Yang.,Chen, Da Chun.,Xiu, Mei Hong.,Haile, Colin N..,Sun, Hongqiang.,...&Zhang, XY .(2012).Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study.PLOS ONE,7(5).
MLA Zhang, Xiang Yang,et al."Cigarette Smoking and Cognitive Function in Chinese Male Schizophrenia: A Case-Control study".PLOS ONE 7.5(2012).
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