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Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial
Yang, Li1; Cao, Qingjiu1; Shuai, Lan1; Li, Haimei1; Chan, Raymond C. K.2; Wang, Yufeng1; Wang, YF (reprint author), 51 Huayuan Bei Rd, Beijing 100191, Peoples R China.
2012-02-01
Source PublicationINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
ISSN1461-1457
SubtypeArticle
Volume15Issue:1Pages:15-26
Contribution Rank2
AbstractThis study aimed to compare the effects of osmotic release oral system-methylphenidate (OROS-MPH) and atomoxetine (ATX) on executive function in children and adolescents with attention deficit hyperactivity disorder (ADHD) by a randomized controlled trial. Subjects who met DSM-IV ADHD criteria were randomized to receive either OROS-MPH or ATX treatment. The doses were titrated to achieve optimal response and then maintained for 4-6 wk. A battery of executive function tests and the Behavior Rating Inventory of Executive Function (BRIEF) were administered to subjects who completed the dose titration (OROS-MPH, n = 85; ATX, n = 57) at the pre- and post-treatment periods. Forty-six children without ADHD were recruited as controls. Both OROS-MPH and ATX significantly improved scores in the Rey Complex Figure Test (RCFT), digit span, and Stroop color-word task. The scores in RCFT and the reverse digit span were not significantly different from the control group at post-treatment assessment (OROS-MPH = ATX = control, p > 0.05), whereas the word interference time of the Stroop test was still more than that of the control group (OROS-MPH = ATX > control, p > 0.05). OROS-MPH also significantly improved the total correct response in the verbal fluency test to normal level, and the shifting time in the trail-making test to subnormal level. The current findings suggest both OROS-MPH and ATX improved executive function generally in children and adolescents with ADHD, and could return working memory back to normative performance level.
KeywordAttention deficit hyperactivity disorder atomoxetine executive function osmotic release oral system-methylphenidate (OROS-MPH)
Subject AreaDevelopmental Psychology
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China [30800302] ; Chinese Ministry of Health [200802073] ; Ministry of Science and Technology [2007BAI17B03] ; Xian-Janssen Pharmaceutical Ltd [CON-I-07-CN-029-B] ; Xian-Janssen ; Eli Lilly
Project Intro.This research was funded by National Natural Science Foundation of China (30800302), Chinese Ministry of Health grants (200802073), Ministry of Science and Technology grants (2007BAI17B03) and the Xian-Janssen Pharmaceutical Ltd (CON-I-07-CN-029-B). We acknowledge the Clinical Epidemiology Research Centre of Peking University Third Hospital, for assistance in generating the randomization envelope. We also thank postgraduate fellows Qiaoxin Du, Ning Ji, Lu Liu, Li An, Yi Su, who helped in the data collection.The corresponding author was supported by a research grant from Xian-Janssen. The first author received consulting fees from Eli Lilly and lecture fees from Xian-Janssen Pharmaceutical Ltd.
WOS IDWOS:000299498600002
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Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11447
Collection脑与认知科学国家重点实验室
Corresponding AuthorWang, YF (reprint author), 51 Huayuan Bei Rd, Beijing 100191, Peoples R China.
Affiliation1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Yang, Li,Cao, Qingjiu,Shuai, Lan,et al. Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2012,15(1):15-26.
APA Yang, Li.,Cao, Qingjiu.,Shuai, Lan.,Li, Haimei.,Chan, Raymond C. K..,...&Wang, YF .(2012).Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,15(1),15-26.
MLA Yang, Li,et al."Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 15.1(2012):15-26.
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