PSYCH OpenIR  > 脑与认知科学国家重点实验室
Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial
Yang, Li1; Cao, Qingjiu1; Shuai, Lan1; Li, Haimei1; Chan, Raymond C. K.2; Wang, Yufeng1; Wang, YF (reprint author), 51 Huayuan Bei Rd, Beijing 100191, Peoples R China.
2012-02-01
发表期刊INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
ISSN1461-1457
文章类型Article
卷号15期号:1页码:15-26
产权排序2
摘要This study aimed to compare the effects of osmotic release oral system-methylphenidate (OROS-MPH) and atomoxetine (ATX) on executive function in children and adolescents with attention deficit hyperactivity disorder (ADHD) by a randomized controlled trial. Subjects who met DSM-IV ADHD criteria were randomized to receive either OROS-MPH or ATX treatment. The doses were titrated to achieve optimal response and then maintained for 4-6 wk. A battery of executive function tests and the Behavior Rating Inventory of Executive Function (BRIEF) were administered to subjects who completed the dose titration (OROS-MPH, n = 85; ATX, n = 57) at the pre- and post-treatment periods. Forty-six children without ADHD were recruited as controls. Both OROS-MPH and ATX significantly improved scores in the Rey Complex Figure Test (RCFT), digit span, and Stroop color-word task. The scores in RCFT and the reverse digit span were not significantly different from the control group at post-treatment assessment (OROS-MPH = ATX = control, p > 0.05), whereas the word interference time of the Stroop test was still more than that of the control group (OROS-MPH = ATX > control, p > 0.05). OROS-MPH also significantly improved the total correct response in the verbal fluency test to normal level, and the shifting time in the trail-making test to subnormal level. The current findings suggest both OROS-MPH and ATX improved executive function generally in children and adolescents with ADHD, and could return working memory back to normative performance level.
关键词Attention deficit hyperactivity disorder atomoxetine executive function osmotic release oral system-methylphenidate (OROS-MPH)
学科领域Developmental Psychology
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China [30800302] ; Chinese Ministry of Health [200802073] ; Ministry of Science and Technology [2007BAI17B03] ; Xian-Janssen Pharmaceutical Ltd [CON-I-07-CN-029-B] ; Xian-Janssen ; Eli Lilly
项目简介This research was funded by National Natural Science Foundation of China (30800302), Chinese Ministry of Health grants (200802073), Ministry of Science and Technology grants (2007BAI17B03) and the Xian-Janssen Pharmaceutical Ltd (CON-I-07-CN-029-B). We acknowledge the Clinical Epidemiology Research Centre of Peking University Third Hospital, for assistance in generating the randomization envelope. We also thank postgraduate fellows Qiaoxin Du, Ning Ji, Lu Liu, Li An, Yi Su, who helped in the data collection.The corresponding author was supported by a research grant from Xian-Janssen. The first author received consulting fees from Eli Lilly and lecture fees from Xian-Janssen Pharmaceutical Ltd.
WOS记录号WOS:000299498600002
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11447
专题脑与认知科学国家重点实验室
通讯作者Wang, YF (reprint author), 51 Huayuan Bei Rd, Beijing 100191, Peoples R China.
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Yang, Li,Cao, Qingjiu,Shuai, Lan,et al. Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2012,15(1):15-26.
APA Yang, Li.,Cao, Qingjiu.,Shuai, Lan.,Li, Haimei.,Chan, Raymond C. K..,...&Wang, YF .(2012).Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,15(1),15-26.
MLA Yang, Li,et al."Comparative study of OROS-MPH and atomoxetine on executive function improvement in ADHD: a randomized controlled trial".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 15.1(2012):15-26.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000299498600002.p(139KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Li]的文章
[Cao, Qingjiu]的文章
[Shuai, Lan]的文章
百度学术
百度学术中相似的文章
[Yang, Li]的文章
[Cao, Qingjiu]的文章
[Shuai, Lan]的文章
必应学术
必应学术中相似的文章
[Yang, Li]的文章
[Cao, Qingjiu]的文章
[Shuai, Lan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: WOS000299498600002.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。