PSYCH OpenIR  > 中国科学院心理健康重点实验室
Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility
Snyder, Kevin2; Wang, Wei-Wen3; Han, Rebecca2; McFadden, Kile1; Valentino, Rita J.1; Valentino, RJ (reprint author), Childrens Hosp Philadelphia, Abramson Pediat Res Ctr 402D, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA.
2012
Source PublicationNEUROPSYCHOPHARMACOLOGY
ISSN0893-133X
SubtypeArticle
Volume37Issue:2Pages:520-530
Contribution Rank2
AbstractCorticotropin-releasing factor (CRF), the stress-related neuropeptide, acts as a neurotransmitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during stress. CRF shifts the mode of LC discharge from a phasic to a high tonic state that is thought to promote behavioral flexibility. To investigate this, the effects of CRF administered either intracerebroventricularly (30-300 ng, i.c.v.) or directly into the LC (intra-LC; 2-20 ng) were examined in a rat model of attentional set shifting. CRF differentially affected components of the task depending on dose and route of administration. Intracerebroventricular CRF impaired intradimensional set shifting, reversal learning, and extradimensional set shifting (EDS) at different doses. In contrast, intra-LC CRF did not impair any aspect of the task. The highest dose of CRF (20 ng) facilitated reversal learning and the lowest dose (2 ng) improved EDS. The dose-response relationship for CRF on EDS performance resembled an inverted U-shaped curve with the highest dose having no effect. Intra-LC CRF also elicited c-fos expression in prefrontal cortical neurons with an inverted U-shaped dose-response relationship. The number of c-fos profiles was positively correlated with EDS performance. Given that CRF excites LC neurons, the ability of intra-LC CRF to activate prefrontal cortical neurons and facilitate EDS is consistent with findings implicating LC-norepinephrine projections to medial prefrontal cortex in this process. Importantly, the results suggest that CRF release in the LC during stress facilitates shifting of attention between diverse stimuli in a dynamic environment so that the organism can adapt an optimal strategy for coping with the challenge. Neuropsychopharmacology (2012) 37, 520-530; doi:10.1038/npp.2011.218; published online 12 October 2011
Keywordstress set shifting behavioral flexibility prefrontal cortex reversal learning norepinephrine
Subject AreaCognitive Neuroscience
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationPHS [MH40008, DA09082, MH14654] ; ARO [58077-LS-DRP] ; National Basic Research Program of China [2007CB512306] ; Institute of Psychology Beijing [09CX133013] ; Chinese Academy of Sciences [KSCX2-EW-J-8]
Project Intro.This research was supported by PHS Grant MH40008, DA09082, MH14654 (KS), ARO 58077-LS-DRP (S Bhatnagar), National Basic Research Program of China (2007CB512306), Institute of Psychology Beijing (09CX133013), and the Chinese Academy of Sciences (KSCX2-EW-J-8). We acknowledge the assistance of Rosemary Trumbull and statistical consultation with Nayla Chaijale.
WOS IDWOS:000298342500022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11456
Collection中国科学院心理健康重点实验室
Corresponding AuthorValentino, RJ (reprint author), Childrens Hosp Philadelphia, Abramson Pediat Res Ctr 402D, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA.
Affiliation1.Childrens Hosp Philadelphia, Abramson Pediat Res Ctr 402D, Dept Anesthesiol & Crit Care Med, Philadelphia, PA 19104 USA
2.Univ Penn, Philadelphia, PA 19104 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Snyder, Kevin,Wang, Wei-Wen,Han, Rebecca,et al. Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility[J]. NEUROPSYCHOPHARMACOLOGY,2012,37(2):520-530.
APA Snyder, Kevin,Wang, Wei-Wen,Han, Rebecca,McFadden, Kile,Valentino, Rita J.,&Valentino, RJ .(2012).Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility.NEUROPSYCHOPHARMACOLOGY,37(2),520-530.
MLA Snyder, Kevin,et al."Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility".NEUROPSYCHOPHARMACOLOGY 37.2(2012):520-530.
Files in This Item:
File Name/Size DocType Version Access License
WOS000298342500022.p(581KB) 限制开放Apache LicenseView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Snyder, Kevin]'s Articles
[Wang, Wei-Wen]'s Articles
[Han, Rebecca]'s Articles
Baidu academic
Similar articles in Baidu academic
[Snyder, Kevin]'s Articles
[Wang, Wei-Wen]'s Articles
[Han, Rebecca]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Snyder, Kevin]'s Articles
[Wang, Wei-Wen]'s Articles
[Han, Rebecca]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000298342500022.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.