Decreased interhemispheric coordination in schizophrenia: A resting state fMRI study

	Decreased interhemispheric coordination in schizophrenia: A resting state fMRI study
	Hoptman, Matthew J.1,2; Zuo, Xi-Nian3 ; D'Angelo, Debra 1; Mauro, Cristina J.1; Butler, Pamela D.1,2; Milham, Michael P.1,4; Javitt, Daniel C.1,5; Hoptman, MJ (reprint author), Nathan S Kline Inst Psychiat Res, Schizophrenia Res Div, 140 Old Orangeburg Rd,Bldg 35, Orangeburg, NY 10962 USA.
心理所单位排序	3
摘要	Schizophrenia has been increasingly conceptualized as a disorder of brain connectivity, in large part due to findings emerging from white matter and functional connectivity (FC) studies. This work has focused primarily on within-hemispheric connectivity, however some evidence has suggested abnormalities in callosal structure and interhemispheric interaction. Here we examined functional connectivity between homotopic points in the brain using a technique called voxel-mirrored homotopic connectivity (VMHC). We performed VMHC analyses on resting state fMRI data from 23 healthy controls and 25 patients with schizophrenia or schizoaffective disorder. We found highly significant reductions in VMHC in patients for a number of regions, particularly the occipital lobe, the thalamus, and the cerebellum. No regions of increased VMHC were detected in patients. VMHC in the postcentral gyrus extending into the precentral gyrus was correlated with PANSS Total scores. These results show substantial impairment of interhemispheric coordination in schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Schizophrenia Resting state Interhemispheric MRI\
学科领域	Abnormal Psychology
	2012-10-01
语种	英语
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	141 期号:1 页码:1-7
期刊论文类型	Article
URL	查看原文
收录类别	SSCI
项目简介	This study is supported by NIH grants R01MH64783 and R21 MH084031 to MJH, R01 MH066374 to PDB, BRAINS R01 MH094639 to MPM, and R37 MH049334 and P50 MH086385 to DJC, and by grants provided by the National Alliance for Research on Schizophrenia and Depression, a gift from Joe Healy, and the endowment provided by Phyllis Green and Randolph Cowen gifts to Francisco Xavier Castellanos. Dr. Xi-Nian Zuo acknowledges support from Startup Foundation for Distinguished Research Professor of Institute for Psychology (Y0CX492S03), and the Natural Science Foundation of China (81171409).The authors report the following conflicts of interest: Dr. Daniel C. Javitt does consulting for Sanofi, Solvay, Pfizer, Lundbeck, AstraZeneca, NPS Pharmaceuticals, Takeda, Sepracor, Schering Plough, Cypress Bio, and Merck. He has research support from Pfizer, and he has equity in Glytech, and AASI. He also serves on the advisory board of Pfizer. Matthew J. Hoptman, Pamela D. Butler, Debra D'Angelo, Cristina J. Mauro, Xi-Nian Zuo, and Michael P. Milham have declared no conflicts of interest in relation to the subject of this study.
WOS记录号	WOS:000308709100002
资助机构	NIH [R01MH64783, R21 MH084031, R01 MH066374, BRAINS R01 MH094639, R37 MH049334, P50 MH086385] ; National Alliance for Research on Schizophrenia and Depression ; Startup Foundation for Distinguished Research Professor of Institute for Psychology [Y0CX492S03] ; Natural Science Foundation of China [81171409] ; Pfizer
引用统计	被引频次：120[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11458
专题	中国科学院行为科学重点实验室
通讯作者	Hoptman, MJ (reprint author), Nathan S Kline Inst Psychiat Res, Schizophrenia Res Div, 140 Old Orangeburg Rd,Bldg 35, Orangeburg, NY 10962 USA.
作者单位	1.Nathan S Kline Inst Psychiat Res, Schizophrenia Res Div, Orangeburg, NY 10962 USA 2.NYU, Sch Med, Dept Psychiat, New York, NY USA 3.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci,Magnet Resonance Imaging Res Ct, Beijing 100101, Peoples R China 4.Child Mind Inst, New York, NY USA 5.Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA
推荐引用方式 GB/T 7714	Hoptman, Matthew J.,Zuo, Xi-Nian,D'Angelo, Debra,et al. Decreased interhemispheric coordination in schizophrenia: A resting state fMRI study[J]. SCHIZOPHRENIA RESEARCH,2012,141(1):1-7.
APA	Hoptman, Matthew J..,Zuo, Xi-Nian.,D'Angelo, Debra.,Mauro, Cristina J..,Butler, Pamela D..,...&Hoptman, MJ .(2012).Decreased interhemispheric coordination in schizophrenia: A resting state fMRI study.SCHIZOPHRENIA RESEARCH,141(1),1-7.
MLA	Hoptman, Matthew J.,et al."Decreased interhemispheric coordination in schizophrenia: A resting state fMRI study".SCHIZOPHRENIA RESEARCH 141.1(2012):1-7.

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