PSYCH OpenIR  > 中国科学院心理健康重点实验室
Deficits in sustaining reward responses in subsyndromal and syndromal major depression
Liu, Wen-hua2,3,4; Chan, Raymond C. K.1,5; Wang, Ling-zhi6; Huang, Jia1,5; Cheung, Eric F. C.7; Gong, Qi-yong8; Gollan, Jackie K.9; Chan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
2011-06-01
Source PublicationPROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN0278-5846
SubtypeReview
Volume35Issue:4Pages:1045-1052
Contribution Rank4,5
AbstractPreliminary findings suggest a reduction in capacity to sustain reward responses in major depression. However, relatively little is known about the stability of reward learning over time and the effect of stress on reward responses in depressed individuals. This study aimed to evaluate sustained behaviour to maximize reward in the context of known reinforcement contingencies and to evaluate the extent to which stress influences such behaviour in clinically depressed patients (n = 43), subsyndromally depressed individuals (n = 43), and healthy controls (n = 44). A probabilistic reward learning task with contingencies known to participants was used to evaluate the change of reward response over time in both 'stress' and 'non-stress' conditions. Stress was induced by salient negative feedback during the task performance. Questionnaires capturing subjective affect were also administered to all participants after completion of the task. Response bias to the stimulus signaling greater reward decreased significantly over time in both subsyndromally and clinically depressed participants, but not in healthy controls. Healthy controls demonstrated a trend of dysfunctional reward processing under the stress condition. Moreover, in the stress condition, the deficit in sustaining behaviour to maximize reward was associated with subjective rating of pleasure in participants with either subsyndromal depression or major depression. These findings suggest that individuals with depression have difficulty sustaining behaviour during a known reinforcement schedule. Participants with anhedonic symptoms are even less likely to sustain behaviour to maximize reward under stress. (C) 2011 Elsevier Inc. All rights reserved.
KeywordAnhedonia Depression Reward responses Stress
Subject AreaAbnormal Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationSun Yat-Sen University, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences [16000-3253182] ; Project-Oriented Hundred Talents Programme [O7CX031003] ; Chinese Academy of Sciences [KSCX2-YW-R-131, KSCX2-EW-J-8] ; National Basic Research Programme (973 Programme) [2007CB512302/5] ; National Science Foundation China [81088001]
Project Intro.This study was supported by the 100-Scholar Plan (16000-3253182) of Sun Yat-Sen University, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, the Project-Oriented Hundred Talents Programme (O7CX031003), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131 & KSCX2-EW-J-8), and the National Basic Research Programme (973 Programme No. 2007CB512302/5), and the National Science Foundation China Outstanding Young Investigator Award (81088001) to Raymond Chan.
WOS IDWOS:000291848000034
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11460
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, RCK (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Sun Yat Sen Univ, Fac Life Sci, Guangzhou 510275, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China
4.Guangzhou Med Coll, Fac Humanities & Social Sci, Guangzhou, Guangdong, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Guangzhou Psychiat Hosp, Dept Clin Psychol, Guangzhou, Guangdong, Peoples R China
7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
8.Sichuan Univ, Huaxi MR Res Ctr, Dept Radiol, W China Hosp,W China Sch Med, Chengdu 610064, Peoples R China
9.Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA
Recommended Citation
GB/T 7714
Liu, Wen-hua,Chan, Raymond C. K.,Wang, Ling-zhi,et al. Deficits in sustaining reward responses in subsyndromal and syndromal major depression[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2011,35(4):1045-1052.
APA Liu, Wen-hua.,Chan, Raymond C. K..,Wang, Ling-zhi.,Huang, Jia.,Cheung, Eric F. C..,...&Chan, RCK .(2011).Deficits in sustaining reward responses in subsyndromal and syndromal major depression.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,35(4),1045-1052.
MLA Liu, Wen-hua,et al."Deficits in sustaining reward responses in subsyndromal and syndromal major depression".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 35.4(2011):1045-1052.
Files in This Item:
File Name/Size DocType Version Access License
WOS000291848000034.p(366KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, Wen-hua]'s Articles
[Chan, Raymond C. K.]'s Articles
[Wang, Ling-zhi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Wen-hua]'s Articles
[Chan, Raymond C. K.]'s Articles
[Wang, Ling-zhi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Wen-hua]'s Articles
[Chan, Raymond C. K.]'s Articles
[Wang, Ling-zhi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000291848000034.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.