Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats

	Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats
	Wu, Yan 1,2; Li, Yonghui1 ; Gao, Jun1,2 ; Sui, Nan1 ; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
心理所单位排序	1
摘要	Dysfunctional reconsolidation processes may help drug memories resist extinction and contribute to high rate of relapse. Reconsolidation of drug memory is mainly affected by the appetitive and aversive emotional experiences associated with an addictive drug. The nucleus accumbens has been shown to mediate the reconsolidation of positive emotional addictive memory, but its role in negative emotional addictive memory remains elusive. In the present study, we used morphine-induced CPP (m-CPP) and morphine-naloxone induced conditioned place aversion (m-CPA) to investigate the role of N-methyl-D-aspartate (NMDA) receptors within the nucleus accumbens on reconsolidation of emotional drug memory. Here we demonstrate that infusion of the NMDA receptor antagonist, D-(-)-2 amino-5-phosphonopentanoic acid ((D)-APV). into the nucleus accumbens before memory reactivation disrupts the reconsolidation of m-CPP, but does not affect m-CPA. The effect on m-CPP reconsolidation depended on memory reactivation: (D)-APV infusion had no effect in the absence of reactivation. The findings show that the glutamatergic NMDA receptor in nucleus accumbens mechanisms involved in reconsolidating aversive and positive morphine-associated memories can be dissociated. (C) 2011 Elsevier B.V. All rights reserved.
关键词	Reconsolidation Morphine Appetitive and aversive memory NMDA receptor Nucleus accumbens
学科领域	Cognitive Psychology
	2012-01-15
语种	英语
发表期刊	EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN	0014-2999
卷号	674 期号:2-3 页码:321-326
期刊论文类型	Article
收录类别	SCI
项目简介	This work was supported by the National Basic Research Program Grant (2009CB522002), the Chinese Academy of Sciences Grant (KSCX2-EW-R-12), and National Natural Science Foundation Grants (30600184, 31070911). We thank Professor Stephen Brimijoin for his critical reading and revision.
WOS记录号	WOS:000300200000032
资助机构	National Basic Research Program [2009CB522002] ; Chinese Academy of Sciences [KSCX2-EW-R-12] ; National Natural Science Foundation [30600184, 31070911]
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11464
专题	中国科学院心理健康重点实验室
通讯作者	Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Wu, Yan,Li, Yonghui,Gao, Jun,et al. Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,674(2-3):321-326.
APA	Wu, Yan,Li, Yonghui,Gao, Jun,Sui, Nan,&Sui, N .(2012).Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,674(2-3),321-326.
MLA	Wu, Yan,et al."Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 674.2-3(2012):321-326.

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