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Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats
Wu, Yan1,2; Li, Yonghui1; Gao, Jun1,2; Sui, Nan1; Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
2012-01-15
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型Article
卷号674期号:2-3页码:321-326
产权排序1
摘要Dysfunctional reconsolidation processes may help drug memories resist extinction and contribute to high rate of relapse. Reconsolidation of drug memory is mainly affected by the appetitive and aversive emotional experiences associated with an addictive drug. The nucleus accumbens has been shown to mediate the reconsolidation of positive emotional addictive memory, but its role in negative emotional addictive memory remains elusive. In the present study, we used morphine-induced CPP (m-CPP) and morphine-naloxone induced conditioned place aversion (m-CPA) to investigate the role of N-methyl-D-aspartate (NMDA) receptors within the nucleus accumbens on reconsolidation of emotional drug memory. Here we demonstrate that infusion of the NMDA receptor antagonist, D-(-)-2 amino-5-phosphonopentanoic acid ((D)-APV). into the nucleus accumbens before memory reactivation disrupts the reconsolidation of m-CPP, but does not affect m-CPA. The effect on m-CPP reconsolidation depended on memory reactivation: (D)-APV infusion had no effect in the absence of reactivation. The findings show that the glutamatergic NMDA receptor in nucleus accumbens mechanisms involved in reconsolidating aversive and positive morphine-associated memories can be dissociated. (C) 2011 Elsevier B.V. All rights reserved.
关键词Reconsolidation Morphine Appetitive and aversive memory NMDA receptor Nucleus accumbens
学科领域Cognitive Psychology
收录类别SCI
语种英语
项目资助者National Basic Research Program [2009CB522002] ; Chinese Academy of Sciences [KSCX2-EW-R-12] ; National Natural Science Foundation [30600184, 31070911]
项目简介This work was supported by the National Basic Research Program Grant (2009CB522002), the Chinese Academy of Sciences Grant (KSCX2-EW-R-12), and National Natural Science Foundation Grants (30600184, 31070911). We thank Professor Stephen Brimijoin for his critical reading and revision.
WOS记录号WOS:000300200000032
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11464
专题中国科学院心理健康重点实验室
通讯作者Sui, N (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China.
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Wu, Yan,Li, Yonghui,Gao, Jun,et al. Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,674(2-3):321-326.
APA Wu, Yan,Li, Yonghui,Gao, Jun,Sui, Nan,&Sui, N .(2012).Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats.EUROPEAN JOURNAL OF PHARMACOLOGY,674(2-3),321-326.
MLA Wu, Yan,et al."Differential effect of NMDA receptor antagonist in the nucleus accumbens on reconsolidation of morphine -related positive and aversive memory in rats".EUROPEAN JOURNAL OF PHARMACOLOGY 674.2-3(2012):321-326.
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