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Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm
Bai, Yunjing; Peng, Yonghua; Liang, Jing; Zheng, Xigeng; Zheng, XG (reprint author), Datun Rd A10, Beijing 100101, Peoples R China.
2012-08-15
发表期刊EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN0014-2999
文章类型Article
卷号689期号:1-3页码:118-124
产权排序1
摘要The transition to addiction often involves a gradual process of escalated drug intake. The purpose of the present study was to characterize neuronal activation in the ventral tegmental area (VTA) and substantia nigra (SN) following chronic escalating-dose morphine exposure (days 1-7, 2 mg/kg/d; days 8-21, beginning at 10 mg/kg/d, increasing by 2 mg/kg/d), with steady-dose morphine (2 mg/kg/d, i.p., for 21 days) as the comparison. Using immunohistochemical double-staining for tyrosine hydroxylase (TH) and Fos, we found that the number of Fos(+)TH(+) neurons in the rostral VTA and number of Fos(+)TH(-) neurons in the lateral SNr were significantly increased in escalating-dose morphine-treated rats compared with steady-dose morphine-treated rats and acute morphine-treated rats. Meanwhile, this increase was associated with robust expression of behavioral sensitization after a challenge with 10 mg/kg morphine. The number of Fos(+)TH(+) neurons was significantly increased by acute morphine in the caudal VTA and SNc, but this number did not increase further with morphine pretreatment. These results demonstrate that behavioral sensitization was associated with elevated activation of dopaminergic neurons in the rostral VTA and nondopaminergic neurons in the lateral SNr, which could only be induced by chronic escalating-dose morphine rather than chronic steady-dose morphine pretreatment. (C) 2012 Elsevier B.V. All rights reserved.
关键词Fos Rostral ventral tegmental area Substantia nigra pars reticulata Behavioral sensitization Morphine Escalating-dose
学科领域Physiological Psychology/biological Psychology
收录类别SCI
语种英语
项目资助者National Foundation of Natural Science [30900400, 30971057, 31000463] ; Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences [YOCX011S01]
项目简介This work was supported by the National Foundation of Natural Science (nos. 30900400, 30971057 and 31000463), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-EW-J-8) and Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (no. YOCX011S01).
WOS记录号WOS:000306646900016
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11466
专题中国科学院心理健康重点实验室
通讯作者Zheng, XG (reprint author), Datun Rd A10, Beijing 100101, Peoples R China.
作者单位Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Bai, Yunjing,Peng, Yonghua,Liang, Jing,et al. Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2012,689(1-3):118-124.
APA Bai, Yunjing,Peng, Yonghua,Liang, Jing,Zheng, Xigeng,&Zheng, XG .(2012).Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm.EUROPEAN JOURNAL OF PHARMACOLOGY,689(1-3),118-124.
MLA Bai, Yunjing,et al."Differential patterns of neuronal activation in rostral versus caudal ventral tegmental area involved in behavioral sensitization induced by an escalating-dose morphine administration paradigm".EUROPEAN JOURNAL OF PHARMACOLOGY 689.1-3(2012):118-124.
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