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Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals
Mellacqua, Zefiro1; Eyeson, Joanna1; Orr, Ken D.2; Morgan, Kevin D.1; Zanelli, Jolanta1; Lloyd, Tuhina3; Morgan, Craig1; Fearon, Paul1; Hutchinson, Gerard; Doody, Gillian A.; Chan, Raymond C. K.4; Harrison, Glynn5; Jones, Peter B.6; Murray, Robin M.1; Reichenberg, Abraham1; Dazzan, Paola1; Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, PO 40,Crespigny Pk, London SE5 8AF, England.
2012-12-01
发表期刊SCHIZOPHRENIA RESEARCH
ISSN0920-9964
文章类型Article
卷号142期号:1-3页码:159-164
产权排序5
摘要The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are specific to psychosis is essential to inform the pathophysiology of this disorder. We evaluated a large epidemiological sample of patients with first episode psychosis (n = 242) and a population-based sample of healthy individuals (n = 155), as part of the AESOP study. We examined neurological soft signs using the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989), and generalized and specific cognitive deficits (memory; verbal abilities; attention, concentration and mental speed; executive functions and working memory; language; visual constructual/perceptual abilities). In patients, more neurological signs across all subscales were associated with worse general cognitive function, while in controls this was only present for sensory integration and sequencing signs. Furthermore, in patients, but not in healthy individuals, more sensory integrative signs were associated with deficits in specific cognitive domains, such as memory, verbal abilities, language, visual/perceptual, executive function (p ranging <0.001-0.002); sequencing signs with language, executive function, and attention (p<0.001-0.004); and motor signs with poorer verbal abilities (p=0.001). These findings indicate the presence of specific associations between neurological and cognitive deficits in psychosis that are distinct from those of healthy individuals. (C) 2012 Elsevier B.V. All rights reserved.
关键词Schizophrenia Neurological signs IQ Motor coordination Executive function First episode psychosis Healthy individuals
学科领域Abnormal Psychology
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收录类别SSCI
语种英语
项目资助者UK Medical Research Council ; Stanley Medical Research Institute ; NARSAD ; BIAL Foundation ; National Science Fund China Young Investigator Award [81088001] ; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of psychology
项目简介This study was funded by the UK Medical Research Council. We thank the Stanley Medical Research Institute for their support. Paola Dazzan's research is supported by NARSAD and the BIAL Foundation. Raymond Chan is supported by grants from the National Science Fund China Young Investigator Award (81088001), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of psychology.
WOS记录号WOS:000311220900024
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11467
专题脑与认知科学国家重点实验室
通讯作者Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, PO 40,Crespigny Pk, London SE5 8AF, England.
作者单位1.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 8AF, England
2.Sir Charles Gairdner Hosp, Dept Psychiat, Perth, WA, Australia
3.Univ Nottingham, Dept Psychiat, Nottingham NG7 2RD, England
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
5.Univ Bristol, Acad Unit Psychiat, Bristol, Avon, England
6.Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England
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Mellacqua, Zefiro,Eyeson, Joanna,Orr, Ken D.,et al. Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals[J]. SCHIZOPHRENIA RESEARCH,2012,142(1-3):159-164.
APA Mellacqua, Zefiro.,Eyeson, Joanna.,Orr, Ken D..,Morgan, Kevin D..,Zanelli, Jolanta.,...&Dazzan, P .(2012).Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals.SCHIZOPHRENIA RESEARCH,142(1-3),159-164.
MLA Mellacqua, Zefiro,et al."Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals".SCHIZOPHRENIA RESEARCH 142.1-3(2012):159-164.
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