Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals

	Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals
	Mellacqua, Zefiro 1; Eyeson, Joanna 1; Orr, Ken D.2; Morgan, Kevin D.1; Zanelli, Jolanta 1; Lloyd, Tuhina 3; Morgan, Craig 1; Fearon, Paul 1; Hutchinson, Gerard ; Doody, Gillian A.; Chan, Raymond C. K.4 ; Harrison, Glynn 5; Jones, Peter B.6; Murray, Robin M.1; Reichenberg, Abraham 1; Dazzan, Paola 1; Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, PO 40,Crespigny Pk, London SE5 8AF, England.
心理所单位排序	5
摘要	The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are specific to psychosis is essential to inform the pathophysiology of this disorder. We evaluated a large epidemiological sample of patients with first episode psychosis (n = 242) and a population-based sample of healthy individuals (n = 155), as part of the AESOP study. We examined neurological soft signs using the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989), and generalized and specific cognitive deficits (memory; verbal abilities; attention, concentration and mental speed; executive functions and working memory; language; visual constructual/perceptual abilities). In patients, more neurological signs across all subscales were associated with worse general cognitive function, while in controls this was only present for sensory integration and sequencing signs. Furthermore, in patients, but not in healthy individuals, more sensory integrative signs were associated with deficits in specific cognitive domains, such as memory, verbal abilities, language, visual/perceptual, executive function (p ranging <0.001-0.002); sequencing signs with language, executive function, and attention (p<0.001-0.004); and motor signs with poorer verbal abilities (p=0.001). These findings indicate the presence of specific associations between neurological and cognitive deficits in psychosis that are distinct from those of healthy individuals. (C) 2012 Elsevier B.V. All rights reserved.
关键词	Schizophrenia Neurological signs IQ Motor coordination Executive function First episode psychosis Healthy individuals
学科领域	Abnormal Psychology
	2012-12-01
语种	英语
发表期刊	SCHIZOPHRENIA RESEARCH
ISSN	0920-9964
卷号	142 期号:1-3 页码:159-164
期刊论文类型	Article
URL	查看原文
收录类别	SSCI
项目简介	This study was funded by the UK Medical Research Council. We thank the Stanley Medical Research Institute for their support. Paola Dazzan's research is supported by NARSAD and the BIAL Foundation. Raymond Chan is supported by grants from the National Science Fund China Young Investigator Award (81088001), the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8), and the Key Laboratory of Mental Health, Institute of psychology.
WOS记录号	WOS:000311220900024
资助机构	UK Medical Research Council ; Stanley Medical Research Institute ; NARSAD ; BIAL Foundation ; National Science Fund China Young Investigator Award [81088001] ; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8] ; Key Laboratory of Mental Health, Institute of psychology
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/11467
专题	脑与认知科学国家重点实验室
通讯作者	Dazzan, P (reprint author), Kings Coll London, Inst Psychiat, Dept Psychosis Studies, PO 40,Crespigny Pk, London SE5 8AF, England.
作者单位	1.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 8AF, England 2.Sir Charles Gairdner Hosp, Dept Psychiat, Perth, WA, Australia 3.Univ Nottingham, Dept Psychiat, Nottingham NG7 2RD, England 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 5.Univ Bristol, Acad Unit Psychiat, Bristol, Avon, England 6.Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England
推荐引用方式 GB/T 7714	Mellacqua, Zefiro,Eyeson, Joanna,Orr, Ken D.,et al. Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals[J]. SCHIZOPHRENIA RESEARCH,2012,142(1-3):159-164.
APA	Mellacqua, Zefiro.,Eyeson, Joanna.,Orr, Ken D..,Morgan, Kevin D..,Zanelli, Jolanta.,...&Dazzan, P .(2012).Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals.SCHIZOPHRENIA RESEARCH,142(1-3),159-164.
MLA	Mellacqua, Zefiro,et al."Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals".SCHIZOPHRENIA RESEARCH 142.1-3(2012):159-164.

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