PSYCH OpenIR  > 中国科学院心理健康重点实验室
Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats
Liang, Jing1,2,3; Ma, Si-Si1,2; Li, Yi-Jing1,2; Ping, Xing-Jie1,2; Hu, Ling1,2; Cui, Cai-Lian1,2; Cui, CL (reprint author), Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, 38 Xueyuan Rd, Beijing 100083, Peoples R China.
2012-07-01
Source PublicationNEUROCHEMICAL RESEARCH
ISSN0364-3190
SubtypeArticle
Volume37Issue:7Pages:1482-1489
Contribution Rank2
AbstractOur previous study demonstrated that morphine dose- and time-dependently elevated dopamine (DA) concentrations in the nucleus accumbens (NAc) during the expression of morphine-induced conditioned place preference (CPP) in rats. However, still unknown are how DA concentrations dynamically change during the morphine-induced CPP test and whether tyrosine hydroxylase (TH) activity in the ventral tegmental area (VTA) plays a vital role in this process. In the present study, we measured dynamic changes in TH and phosphorylated TH serine 40 (pTH Ser(40)) and pTH Ser(31) proteins in the VTA, and DA concentrations in the NAc at 5 min intervals during a 30 min morphine-induced CPP test. Rats that underwent morphine-induced CPP training significantly preferred the morphine-paired chamber during the CPP expression test, an effect that lasted at least 30 min in the drug-free state. DA concentrations in the NAc markedly increased at 15 min when the rats were returned to the CPP boxes to assess the expression of preference for the previously drug-paired chamber. DA concentrations then declined 2 h after the CPP test. TH and pTH Ser(40) levels, but not pTH Ser(31) levels, in the VTA were enhanced during the CPP test. These results indicated that TH and the phosphorylation of TH Ser(40) in the VTA may be responsible for DA synthesis and release in the NAc during the behavioral expression of conditioned reward elicited by a drug-associated context.
KeywordMorphine Conditioned place preference (CPP) Dopamine (DA) Tyrosine hydroxylase (TH)
Subject AreaPhysiological Psychology/biological Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation [30970933] ; National Basic Research Program [2009CB522003]
Project Intro.This work was supported by grants from the National Natural Science Foundation (30970933) and National Basic Research Program (2009CB522003).
WOS IDWOS:000304878200013
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11477
Collection中国科学院心理健康重点实验室
Corresponding AuthorCui, CL (reprint author), Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, 38 Xueyuan Rd, Beijing 100083, Peoples R China.
Affiliation1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Liang, Jing,Ma, Si-Si,Li, Yi-Jing,et al. Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats[J]. NEUROCHEMICAL RESEARCH,2012,37(7):1482-1489.
APA Liang, Jing.,Ma, Si-Si.,Li, Yi-Jing.,Ping, Xing-Jie.,Hu, Ling.,...&Cui, CL .(2012).Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats.NEUROCHEMICAL RESEARCH,37(7),1482-1489.
MLA Liang, Jing,et al."Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats".NEUROCHEMICAL RESEARCH 37.7(2012):1482-1489.
Files in This Item:
File Name/Size DocType Version Access License
WOS000304878200013.p(416KB) 限制开放Apache LicenseView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liang, Jing]'s Articles
[Ma, Si-Si]'s Articles
[Li, Yi-Jing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liang, Jing]'s Articles
[Ma, Si-Si]'s Articles
[Li, Yi-Jing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liang, Jing]'s Articles
[Ma, Si-Si]'s Articles
[Li, Yi-Jing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000304878200013.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.