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Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings
Zhao, Yan Li1; Tan, Shu Ping1; Yang, Fu De1; Wang, Li Li2; Feng, Wen Feng3; Chan, Raymond C. K.4,5; Gao, Xiao6; Zhou, Dong Feng7; Li, Bin Bin1; Song, Chong Sheng1; Fan, Feng Mei1; Tan, Yun Long1; Zhang, Jin Guo1; Wang, Yun Hui1; Zou, Yi Zhuang1; Zou, YZ (reprint author), Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China.
2011-12-01
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
SubtypeArticle
Volume133Issue:1-3Pages:112-119
Contribution Rank4,5
AbstractThe present study combined a time-locked paradigm and high-time-resolution event-related potential (ERP) recordings to examine different phases of working memory, including early visual processing and late memory-related processes of encoding, maintenance, and retrieval, in 67 adults with schizophrenia and 46 healthy controls. Alterations in ERP components were correlated with task performance. Patients performed significantly worse in the working memory task than healthy subjects, although all subjects' accuracy exceeded 80%. During encoding, the N1 and P2 component amplitudes were lower while the P300 amplitude was higher in schizophrenic patients compared to healthy controls. There were no differences between groups with respect to the mean amplitudes of the negative slow waves in the early stage (the first 400 ms) of the maintenance phase. However, in the next 500-ms time window, the patients exhibited a more negative deflection in the middle fronto-central region than the control group. Likewise, a similar pattern was observed in the second 500-ms period in the middle fronto-central region, although the effect was marginally significant. There were no differences between groups in the remaining 1000 ms. During retrieval, the P1, N1 and P2 amplitudes were lower while the P300 amplitude and latency were higher in schizophrenic patients. The present results indicate early visual deficits in the working memory task in adults with schizophrenia. Impairments in the maintenance phase were confined to the late rehearsal stage. The increased P300 amplitude at the fronto-central electrode sites along with the poorer behavioral performance suggests that schizophrenic patients have an inefficient working memory system. (C) 2011 Elsevier B.V. All rights reserved.
KeywordWorking memory Schizophrenia Event-related potentials Sternberg
Subject AreaAbnormal Psychology
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Indexed BySSCI
Language英语
Funding OrganizationBeijing Municipal Science & Technology Commission [D0906001040191] ; Beijing Natural Science Foundation [7102086] ; Fund of Capital Medical Development and Research grant [2007-3059] ; Beijing Municipal Training Programme Foundation for the Talents [2007id0301400101] ; major project of Beijing science and technology [D0906001000091]
Project Intro.This study was partially supported by Beijing Municipal Science & Technology Commission grant (No. D0906001040191), Beijing Natural Science Foundation grant (No. 7102086), Fund of Capital Medical Development and Research grant (No. 2007-3059),and Beijing Municipal Training Programme Foundation for the Talents(No. 2007id0301400101).This work was supported by the major project of Beijing science and technology: D0906001000091.
WOS IDWOS:000298512500018
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11478
Collection中国科学院心理健康重点实验室
Corresponding AuthorZou, YZ (reprint author), Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China.
Affiliation1.Beijing Hui Long Guan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China
2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
3.Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Southwest Univ, Sch Psychol, Chongqing 400715, Peoples R China
7.Peking Univ, Inst Mental Hlth, Beijing 100091, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yan Li,Tan, Shu Ping,Yang, Fu De,et al. Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings[J]. SCHIZOPHRENIA RESEARCH,2011,133(1-3):112-119.
APA Zhao, Yan Li.,Tan, Shu Ping.,Yang, Fu De.,Wang, Li Li.,Feng, Wen Feng.,...&Zou, YZ .(2011).Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings.SCHIZOPHRENIA RESEARCH,133(1-3),112-119.
MLA Zhao, Yan Li,et al."Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings".SCHIZOPHRENIA RESEARCH 133.1-3(2011):112-119.
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