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Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder
Chen, Xiaoyu1; Li, Yonghui5; Li, Sa1; Kirouac, Gilbert J.1,2,3,4; Kirouac, GJ (reprint author), Univ Manitoba, Fac Dent, Dept Oral Biol, 780 Bannatyne Ave, Winnipeg, MB R3E 0W2, Canada.
2012
发表期刊BEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
文章类型Article
卷号226期号:1页码:112-117
产权排序2
摘要Exposure of humans and animals to an intensely fearful experience can lead to an enduring behavioral profile involving fear and avoidance. The present study examined if rats that show more fear to a novel tone one day after exposure to footshocks exhibit more avoidance-like responses over a 4-week period. Rats were exposed to an episode of moderately intense footshock (5 x 2s episodes of 1.5 mA presented randomly over 3 min). Shock rats that exhibited a high level of fear (HR) to a novel tone one day after the shock exposure showed more avoidance of open spaces and novel rats when compared to shock rats that exhibited a lower level of fear to the novel tone (LR). Similarly, HR emitted more ultrasonic vocalization in the dysphoric range (20-30 kHz) when placed in a novel chamber or the chamber in which shock was given. This study highlights the importance of early fear as a contributing factor for the development of lasting changes in avoidance. These results also support the view that the presence of an intense peritraumatic stress response may be a predictor of the subsequent development of a lasting negative emotional state in humans exposed to trauma. (C) 2011 Elsevier B.V. All rights reserved.
关键词Post-traumatic stress disorder Fear Avoidance Footshock Rat Stress
学科领域Physiological Psychology/biological Psychology
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收录类别SCI
语种英语
项目资助者Canadian Institutes of Health Research (CIHR) [MOP68909]
项目简介The study was supported by Canadian Institutes of Health Research (CIHR; MOP68909 to G.J.K.). The authors declare that except for income received from their primary employer, no financial support has been received from any individual or corporate entity.
WOS记录号WOS:000296941400014
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11479
专题中国科学院心理健康重点实验室
通讯作者Kirouac, GJ (reprint author), Univ Manitoba, Fac Dent, Dept Oral Biol, 780 Bannatyne Ave, Winnipeg, MB R3E 0W2, Canada.
作者单位1.Univ Manitoba, Fac Dent, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada
2.Univ Manitoba, Fac Dent, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
3.Univ Manitoba, Fac Med, Dept Oral Biol, Winnipeg, MB R3E 0W2, Canada
4.Univ Manitoba, Fac Med, Dept Psychiat, Winnipeg, MB R3E 0W2, Canada
5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Chen, Xiaoyu,Li, Yonghui,Li, Sa,et al. Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder[J]. BEHAVIOURAL BRAIN RESEARCH,2012,226(1):112-117.
APA Chen, Xiaoyu,Li, Yonghui,Li, Sa,Kirouac, Gilbert J.,&Kirouac, GJ .(2012).Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder.BEHAVIOURAL BRAIN RESEARCH,226(1),112-117.
MLA Chen, Xiaoyu,et al."Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder".BEHAVIOURAL BRAIN RESEARCH 226.1(2012):112-117.
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