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Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats
Han, Xiao1; Li, Nanxin1,2; Xue, Xiaofang1; Shao, Feng1; Wang, Weiwen3; Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
2012-04-04
发表期刊BRAIN RESEARCH
ISSN0006-8993
文章类型Article
卷号1447页码:38-43
产权排序3
摘要Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of pen-adolescent social isolation on latent inhibition (LI) and dopamine 02 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats were randomly divided into adolescent isolation (ISO; isolated housing, 21-34 days of age) and social housing (SOC) groups. LI was tested at postnatal day 56. After behavioral testing, the number of dopamine D2 receptor-expressing cells was determined using immunohistochemistry. Adolescent social isolation impaired LI and increased the number of cells expressing the D2 receptor in the mPFC and NAc. The results suggest that adolescent social isolation produces profound effects on cognitive and dopaminergic function in adult rats, and could be used as an animal model of various neurodevelopmental disorders. (C) 2012 Elsevier B.V. All rights reserved.
关键词Adolescence Social isolation Latent inhibition Dopamine D2 receptor Medial prefrontal cortex Nucleus accumbens
学科领域Physiological Psychology/biological Psychology
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收录类别SCI
语种英语
项目资助者National Natural of Science Foundation of China [31070910, 30500158] ; National Basic Research Program of China (973 Program) [2007CB512306] ; Chinese Academy of Sciences [KSCX2-YW-R-131] ; American Psychological Association ; Institute of Psychology, Chinese Academy of Science [O9KF013001]
项目简介This work was supported by the National Natural of Science Foundation of China (grant No. 31070910, 30500158), National Basic Research Program of China (973 Program, 2007CB512306), the Chinese Academy of Sciences (KSCX2-YW-R-131), American Psychological Association, and grants to young scientists from the Institute of Psychology, Chinese Academy of Science (O9KF013001).
WOS记录号WOS:000303033300005
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被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11481
专题中国科学院心理健康重点实验室
通讯作者Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
作者单位1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
2.Yale Univ, Div Mol Psychiat, Dept Psychol, New Haven, CT 06508 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Han, Xiao,Li, Nanxin,Xue, Xiaofang,et al. Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats[J]. BRAIN RESEARCH,2012,1447:38-43.
APA Han, Xiao,Li, Nanxin,Xue, Xiaofang,Shao, Feng,Wang, Weiwen,&Shao, F .(2012).Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats.BRAIN RESEARCH,1447,38-43.
MLA Han, Xiao,et al."Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats".BRAIN RESEARCH 1447(2012):38-43.
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