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Effects of Apolipoprotein E Genotype on the Off-Line Memory Consolidation
Wang, De-Yi1; Han, Xiu-Jie1,2; Li, Su-Fang1; Liu, Dong-Qiang3,4; Yan, Chao-Gan1,5; Zuo, Xi-Nian1,6; Zhu, Chao-Zhe1; He, Yong1; Kiviniemi, Vesa7; Zang, Yu-Feng1,3,4; Zang, YF (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
2012-12-12
Source PublicationPLOS ONE
ISSN1932-6203
SubtypeArticle
Volume7Issue:12
Contribution Rank5
AbstractSpontaneous brain activity or off-line activity after memory encoding is associated with memory consolidation. A few recent resting-state functional magnetic resonance imaging (RS-fMRI) studies indicate that the RS-fMRI could map off-line memory consolidation effects. However, the gene effects on memory consolidation process remain largely unknown. Here we collected two RS-fMRI sessions, one before and another after an episodic memory encoding task, from two groups of healthy young adults, one with apolipoprotein E (APOE) epsilon 2/epsilon 3 and the other with APOE epsilon 3/epsilon 4. The ratio of regional homogeneity (ReHo), a measure of local synchronization of spontaneous RS-fMRI signal, of the two sessions was used as an index of memory-consolidation. APOE epsilon 3/epsilon 4 group showed greater ReHo ratio within the medial temporal lobe (MTL). The ReHo ratio in MTL was significantly correlated with the recognition memory performance in the APOE epsilon 3/epsilon 4 group but not in epsilon 2/epsilon 3 group. Additionally, APOE epsilon 3/epsilon 4 group showed lower ReHo ratio in the occipital and parietal picture-encoding areas. Our results indicate that APOE epsilon 3/epsilon 4 group may have a different off-line memory consolidation process compared to epsilon 2/epsilon 3 group. These results may help generate future hypotheses that the off-line memory consolidation might be impaired in Alzheimer's disease.
Subject AreaCognitive Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationNSFC [81020108022, 30770594] ; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) ; Ministry of Education of China [B07008]
Project Intro.This study was supported by NSFC (81020108022, 30770594), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT), and the 111 Project from the Ministry of Education of China (B07008). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
WOS IDWOS:000313236200147
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11483
Collection中国科学院行为科学重点实验室
Corresponding AuthorZang, YF (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Anshan Changda Hosp, Dept Neurol, Anshan, Liaoning, Peoples R China
3.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
4.Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China
5.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
6.Chinese Acad Sci, Inst Psychol, Lab Funct Connectome & Dev, Key Lab Behav Sci, Beijing 100101, Peoples R China
7.Univ Hosp Oulu, Dept Diagnost Radiol, Oulu, Finland
Recommended Citation
GB/T 7714
Wang, De-Yi,Han, Xiu-Jie,Li, Su-Fang,et al. Effects of Apolipoprotein E Genotype on the Off-Line Memory Consolidation[J]. PLOS ONE,2012,7(12).
APA Wang, De-Yi.,Han, Xiu-Jie.,Li, Su-Fang.,Liu, Dong-Qiang.,Yan, Chao-Gan.,...&Zang, YF .(2012).Effects of Apolipoprotein E Genotype on the Off-Line Memory Consolidation.PLOS ONE,7(12).
MLA Wang, De-Yi,et al."Effects of Apolipoprotein E Genotype on the Off-Line Memory Consolidation".PLOS ONE 7.12(2012).
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