| Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China | |
He, Shengxi1,2,3; Yu, Longchuan3; Jia, Shaowei1,2; Chen, Qing1,2; Wang, Dongmei4 ; Hu, Shu1,2; Jia, SW (reprint author), Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China.
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| 心理所单位排序 | 3 |
| 摘要 | Very little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients. In the present study, a portable event-related potential (ERP) working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing. In addition, the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients. Results revealed a significant main group effect in reaction time to visual signal stimulations. The reaction time of normal controls was shortest, but longest in opioid-dependent patients. The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls. A significant main group effect was also observed in P100 latency, and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients. P100 amplitude at the Oz-electrode resulted in a significant main group effect. In particular, normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups. These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients. |
| 关键词 | long-term sustained naltrexone release opioid dependence projection of unilateral visual field event-related potential P100 |
| 学科领域 | Medical Psychology |
| 2011-01-25 | |
| 语种 | 英语 |
| 发表期刊 | NEURAL REGENERATION RESEARCH
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| ISSN | 1673-5374 |
| 卷号 | 6期号:3页码:236-240 |
| 期刊论文类型 | Article |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | This work was supported by the Natural Science Foundation of Guangdong Province, No. 06027973; the Science and Technology Development Program of Guangdong Province, No. 2004B3600105; the Medical Science Foundation Program of Guangdong Province, No. A2007592. |
| WOS记录号 | WOS:000288061400013 |
| 资助机构 | Natural Science Foundation of Guangdong Province [06027973] ; Science and Technology Development Program of Guangdong Province [2004B3600105] ; Medical Science Foundation Program of Guangdong Province [A2007592] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/11485 |
| 专题 | 健康与遗传心理学研究室 |
| 通讯作者 | Jia, SW (reprint author), Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China. |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China 2.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China 3.Peking Univ, Coll Life Sci, Beijing 100112, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Shengxi,Yu, Longchuan,Jia, Shaowei,et al. Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China[J]. NEURAL REGENERATION RESEARCH,2011,6(3):236-240. |
| APA | He, Shengxi.,Yu, Longchuan.,Jia, Shaowei.,Chen, Qing.,Wang, Dongmei.,...&Jia, SW .(2011).Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China.NEURAL REGENERATION RESEARCH,6(3),236-240. |
| MLA | He, Shengxi,et al."Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China".NEURAL REGENERATION RESEARCH 6.3(2011):236-240. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS000288061400013.p（652KB） | 限制开放 | Apache License | 请求全文 | |||
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