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Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China
He, Shengxi1,2,3; Yu, Longchuan3; Jia, Shaowei1,2; Chen, Qing1,2; Wang, Dongmei4; Hu, Shu1,2; Jia, SW (reprint author), Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China.
2011-01-25
Source PublicationNEURAL REGENERATION RESEARCH
ISSN1673-5374
SubtypeArticle
Volume6Issue:3Pages:236-240
Contribution Rank3
AbstractVery little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients. In the present study, a portable event-related potential (ERP) working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing. In addition, the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients. Results revealed a significant main group effect in reaction time to visual signal stimulations. The reaction time of normal controls was shortest, but longest in opioid-dependent patients. The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls. A significant main group effect was also observed in P100 latency, and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients. P100 amplitude at the Oz-electrode resulted in a significant main group effect. In particular, normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups. These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients.
Keywordlong-term sustained naltrexone release opioid dependence projection of unilateral visual field event-related potential P100
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of Guangdong Province [06027973] ; Science and Technology Development Program of Guangdong Province [2004B3600105] ; Medical Science Foundation Program of Guangdong Province [A2007592]
Project Intro.This work was supported by the Natural Science Foundation of Guangdong Province, No. 06027973; the Science and Technology Development Program of Guangdong Province, No. 2004B3600105; the Medical Science Foundation Program of Guangdong Province, No. A2007592.
WOS IDWOS:000288061400013
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11485
Collection健康与遗传心理学研究室
Corresponding AuthorJia, SW (reprint author), Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China.
Affiliation1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Coll Life Sci, Beijing 100112, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
He, Shengxi,Yu, Longchuan,Jia, Shaowei,et al. Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China[J]. NEURAL REGENERATION RESEARCH,2011,6(3):236-240.
APA He, Shengxi.,Yu, Longchuan.,Jia, Shaowei.,Chen, Qing.,Wang, Dongmei.,...&Jia, SW .(2011).Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China.NEURAL REGENERATION RESEARCH,6(3),236-240.
MLA He, Shengxi,et al."Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China".NEURAL REGENERATION RESEARCH 6.3(2011):236-240.
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