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Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
Zhang, Xiang Yang1,2,3,4; Zhou, Dong Feng1; Shen, Yu Cun1; Zhang, Pei Yan4; Zhang, Wu Fang1; Liang, Jun1; Chen, Da Chun4; Xiu, Mei Hong4; Kosten, Therese A.2; Kosten, Thomas R.2; Zhang, XY (reprint author), VA Med Ctr, Res Bldg 109,Room 130,2002 Holcombe Blvd, Houston, TX 77030 USA.
2012-04-01
Source PublicationNEUROPHARMACOLOGY
ISSN0028-3908
SubtypeArticle
Volume62Issue:5-6Pages:1928-1934
Contribution Rank3
AbstractOxidative stress may be involved in the pathophysiology of schizophrenia. No double-blind study has compared the effects of typical and atypical antipsychotics on both antioxidant enzyme activity and nitric oxide (NO) levels in schizophrenic patients. Seventy-eight inpatients with chronic schizophrenia were randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol using a double-blind design. Clinical efficacy was determined using the Positive and Negative Syndrome Scale. Blood superoxide dismutase (SOD) and plasma NO levels were measured in patients and 30 normal controls. Our results showed that following a 2-week washout period, levels of SOD and NO were significantly increased in patients with schizophrenia compared to normal controls. Both risperidone and haloperidol equivalently reduced the elevated blood SOD levels in schizophrenia, but neither medication reduced the elevated plasma NO levels in schizophrenia. Low blood SOD levels at baseline predicted greater symptom improvement during treatment, and greater change in SOD was correlated with greater symptom improvement. These results suggest that both typical and atypical antipsychotic drugs may at least partially normalize abnormal free radical metabolism in schizophrenia, and some free radical parameters at baseline may predict antipsychotic responses of schizophrenic patients. (C) 2011 Elsevier Ltd. All rights reserved.
KeywordSchizophrenia Free radical Oxidative stress Antipsychotic treatment
Subject AreaAbnormal Psychology
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Indexed BySCI
Language英语
Funding OrganizationStanley Medical Research Institute [03T-459, 05T-726] ; Beijing Municipal Natural Science Foundation [7072035] ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC),United States National Institute of Health [K05-DA0454, P50-DA18827, U01-MH79639]
Project Intro.This study was partially funded by the Stanley Medical Research Institute (03T-459 and 05T-726), the Beijing Municipal Natural Science Foundation (ID: 7072035), and the Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health K05-DA0454, P50-DA18827 and U01-MH79639.
WOS IDWOS:000301474300003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11488
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, XY (reprint author), VA Med Ctr, Res Bldg 109,Room 130,2002 Holcombe Blvd, Houston, TX 77030 USA.
Affiliation1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
4.Beijing HuiLongGuan Hosp, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiang Yang,Zhou, Dong Feng,Shen, Yu Cun,et al. Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia[J]. NEUROPHARMACOLOGY,2012,62(5-6):1928-1934.
APA Zhang, Xiang Yang.,Zhou, Dong Feng.,Shen, Yu Cun.,Zhang, Pei Yan.,Zhang, Wu Fang.,...&Zhang, XY .(2012).Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia.NEUROPHARMACOLOGY,62(5-6),1928-1934.
MLA Zhang, Xiang Yang,et al."Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia".NEUROPHARMACOLOGY 62.5-6(2012):1928-1934.
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