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Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats
Li, Xianghong2; Luo, Fei1,2; Shi, Lihong3; Woodward, Donald J.4; Chang, Jingyu4; Luo, F (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
2011-10-01
Source PublicationNEUROSCIENCE RESEARCH
ISSN0168-0102
SubtypeArticle
Volume71Issue:2Pages:149-160
Contribution Rank2
AbstractThe question pursued in this study was when neural activity appears in the cortico-basal ganglia system that could predict alternate behavioral responses in a reaction time (RT) task. In this protocol, rats first performed a nose poke to initiate a trial, depressed a lever when presented, and then released the lever after a tone cue. Multiple-channel, single-unit recordings (up to 62 units) were obtained simultaneously from the prefrontal cortex, the dorsal medial striatum, the globus pallidus, and the substantia nigra pars reticulata in a single rat during a session. Results indicated that (1) global alterations of neural activity appeared in clusters, which was associated with different behavioral components and observed in each of the targeted areas; (2) small independent subsets of neurons responded differently between error (lever was released before tone presentation) and correct trials (lever was released within 0.5 s after tone onset) during these behavioral episodes; (3) significant correlations between RTs and single units activities were found in the early preparation phases of the task. The results reveal that complex early preparatory activity exists several seconds before the final movements in a RT task, which may determine executive functions leading to rapid decoding of alternate behavioral performances. (C) 2011 Published by Elsevier Ireland Ltd and the Japan Neuroscience Society.
KeywordStriatum Frontal cortex Substantia nigra pars reticulata Globus pallidus Movement initiation Timing
Subject AreaPhysiological Psychology/biological Psychology
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Indexed BySCI
Language英语
Funding OrganizationTourette Syndrome Association [AA-10337, DA-2338, NS-40628, DA-10370, NS-43441, TW-06144] ; National Natural Science Foundation of China [30770688, 30970959] ; Beijing NNSF [5082008] ; Chinese Academy of Sciences ; National Hi-Tech Research and Development Program of China [2008AA022604] ; NIH Fogarty International Center [R03-TW 008038]
Project Intro.This work was supported by the Tourette Syndrome Association, AA-10337, DA-2338, and NS-40628 to D.J. Woodward, DA-10370, NS-43441, and TW-06144 to J.-Y. Chang, and by the National Natural Science Foundation of China (30770688 and 30970959), a Beijing NNSF grant (5082008), the 100 Talented Plan of the Chinese Academy of Sciences, the National Hi-Tech Research and Development Program of China (Grant No. 2008AA022604), and a grant from NIH Fogarty International Center (R03-TW 008038) to F. Luo.
WOS IDWOS:000295556600007
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11499
Collection中国科学院心理健康重点实验室
Corresponding AuthorLuo, F (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China.
Affiliation1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Wake Forest Univ, Bowman Gray Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC 27103 USA
4.Neurosci Res Inst N Carolina, Winston Salem, NC 27104 USA
Recommended Citation
GB/T 7714
Li, Xianghong,Luo, Fei,Shi, Lihong,et al. Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats[J]. NEUROSCIENCE RESEARCH,2011,71(2):149-160.
APA Li, Xianghong,Luo, Fei,Shi, Lihong,Woodward, Donald J.,Chang, Jingyu,&Luo, F .(2011).Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats.NEUROSCIENCE RESEARCH,71(2),149-160.
MLA Li, Xianghong,et al."Ensemble neural activity of the frontal cortical basal ganglia system predicts reaction time task performance in rats".NEUROSCIENCE RESEARCH 71.2(2011):149-160.
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