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Executive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid test
Liu, Kristy C. M.1; Chan, Raymond C. K.2; Chan, Kevin K. S.1; Tang, Jennifer Y. M.1; Chiu, Cindy P. Y.1; Lam, May M. L.1; Chan, Sherry K. W.1; Wong, Gloria H. Y.1; Hui, Christy L. M.1; Chen, Eric Y. H.1; Chen, EYH (reprint author), Univ Hong Kong, Queen Mary Hosp, Dept Psychiat, 102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
2011-03-01
发表期刊SCHIZOPHRENIA RESEARCH
ISSN0920-9964
文章类型Article
卷号126期号:1-3页码:87-92
产权排序2
摘要Executive function impairment is a key cognitive deficit in schizophrenia. However, traditional neuropsychological tests of executive function may not be sensitive enough to capture the everyday dysexecutive problems experienced by patients. Additionally, existing literature has been inconsistent about longitudinal changes of executive functions in schizophrenia. The present study focuses on examining the longitudinal change of executive functions in schizophrenia using the Modified Six Elements Test (MSET) that was developed based on the Supervisory Attentional System model and shown to be sensitive to everyday dysexecutive problems. In the present study, MSET performance was assessed in 31 medication-naive first-episode schizophrenic patients at four times over a period of three years, while the 31 normal controls were assessed once. Patients demonstrated impairment in MSET as compared to controls. Importantly, the MSET impairment persisted from the medication-naive state to clinical stabilization and the three years following the first psychotic episode though patients improved in a conventional executive test (Modified Wisconsin Card Sorting Test). Performance was not related to intelligence, educational level, symptom changes, age-of-onset, or duration of untreated psychosis. Better MSET performance at medication-naive state predicted improvement in negative and positive symptoms over the three-year period. These findings may suggest that MSET impairment is a primary deficit in schizophrenia that occurs early in the course of the illness and remains stable irrespective of clinical state for at least three years following the first episode of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.
关键词First-episode schizophrenia Medication-naive Longitudinal Cognitive function Executive function Six elements
学科领域Abnormal Psychology
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收录类别SCI
语种英语
WOS记录号WOS:000289025700013
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11506
专题脑与认知科学国家重点实验室
通讯作者Chen, EYH (reprint author), Univ Hong Kong, Queen Mary Hosp, Dept Psychiat, 102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
作者单位1.Univ Hong Kong, Queen Mary Hosp, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
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Liu, Kristy C. M.,Chan, Raymond C. K.,Chan, Kevin K. S.,et al. Executive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid test[J]. SCHIZOPHRENIA RESEARCH,2011,126(1-3):87-92.
APA Liu, Kristy C. M..,Chan, Raymond C. K..,Chan, Kevin K. S..,Tang, Jennifer Y. M..,Chiu, Cindy P. Y..,...&Chen, EYH .(2011).Executive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid test.SCHIZOPHRENIA RESEARCH,126(1-3),87-92.
MLA Liu, Kristy C. M.,et al."Executive function in first-episode schizophrenia: A three-year longitudinal study of an ecologically valid test".SCHIZOPHRENIA RESEARCH 126.1-3(2011):87-92.
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