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Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction
Fang, Kechi2; Zhao, Hansheng2,3; Sun, Changyue2; Lam, Carolyn M. C.1; Chang, Suhua2,4; Zhang, Kunlin2; Panda, Gurudutta1; Godinho, Miguel1,5; dos Santos, Vitor A. P. Martins1,6; Wang, Jing2; dos Santos, VAPM (reprint author), Helmholtz Ctr Infect Res HZI, Syst & Synthet Biol Grp, Inhoffenstr 7, D-38124 Braunschweig, Germany.
2011-05-25
Source PublicationBMC SYSTEMS BIOLOGY
ISSN1752-0509
SubtypeArticle
Volume5
Contribution Rank1
AbstractBackground: Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection. Strain B. cenocepacia J2315 is the most infectious isolate from CF patients. There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationEuropean Union [29104, 222886] ; Ministry of Science and Technology of the People's Republic of China [2011CBA00802] ; Institute of Psychology, Chinese Academy of Sciences [O9CX115011] ; Portuguese Fundacao para a Ciencia e Tecnologia [ERA-PTG/SAU/0003/2008]
Project Intro.We acknowledge funding from the European Union (Projects PROBACTYS: Grant No. 29104 and MICROME: No. 222886), the National Basic Research Program of China (973 Program) (Grant No. 2011CBA00802) from the Ministry of Science and Technology of the People's Republic of China, the Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (Grant No. O9CX115011), and Portuguese Fundacao para a Ciencia e Tecnologia (Project METAGUT; Grant No. ERA-PTG/SAU/0003/2008).
WOS IDWOS:000292106500001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11511
Collection中国科学院心理健康重点实验室
Corresponding Authordos Santos, VAPM (reprint author), Helmholtz Ctr Infect Res HZI, Syst & Synthet Biol Grp, Inhoffenstr 7, D-38124 Braunschweig, Germany.
Affiliation1.Helmholtz Ctr Infect Res HZI, Syst & Synthet Biol Grp, D-38124 Braunschweig, Germany
2.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
3.China Agr Univ, Coll Biol Sci, Beijing 100193, Peoples R China
4.Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China
5.Lifewizz Lda, P-4150616 Oporto, Portugal
6.Wageningen Univ, NL-6703 HB Wageningen, Netherlands
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Fang, Kechi,Zhao, Hansheng,Sun, Changyue,et al. Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction[J]. BMC SYSTEMS BIOLOGY,2011,5.
APA Fang, Kechi.,Zhao, Hansheng.,Sun, Changyue.,Lam, Carolyn M. C..,Chang, Suhua.,...&dos Santos, VAPM .(2011).Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.BMC SYSTEMS BIOLOGY,5.
MLA Fang, Kechi,et al."Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction".BMC SYSTEMS BIOLOGY 5(2011).
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