PSYCH OpenIR  > 中国科学院心理健康重点实验室
Expression of Ephrin Receptors and Ligands in Postmortem Brains of HIV-Infected Subjects With and Without Cognitive Impairment
Yuferov, Vadim; Ho, Ann; Morgello, Susan; Yang, Yaning; Ott, Jurg; Kreek, Mary Jeanne; Yuferov, V (reprint author), Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA.
2013
发表期刊JOURNAL OF NEUROIMMUNE PHARMACOLOGY
ISSN1674-2788
文章类型期刊论文
卷号8期号:1页码:333-344
产权排序4
摘要Despite the successes of combination antiretroviral therapy, HIV-associated neurocognitive disorders persist in many infected individuals. Earlier studies showed that neurocognitive impairment was associated with glutamate toxicity and synaptodendritic damage. We examined alterations in expression of four ephrin genes that are involved in synapse formation and recruitment of glutamate receptors to synapses, in the caudate and anterior cingulate in postmortem brain of cognitively characterized HIV-infected subjects, along with expression of neuronal and astroglial/macroglial markers. Postmortem tissues of HIV-infected and control subjects were obtained from the Manhattan HIV Brain Bank. HIV-infected subjects underwent neurocognitive assessment prior to death. Quantification of mRNA of genes of chemokine receptors and chemokines (CCR5, CXCR4, CCL2), astroglial/microglial markers (GFAP, CD163, CD68), the neuronal marker SNAP25, ephrin receptors EPHA4 and EPHB2, and ephrin ligands EFNB1 and EFNB2 was performed using SYBR Green RT-PCR. Proinflammatory chemokine and glial/macrophage mRNA levels in both regions were significantly greater in HIV+ than in HIV- subjects. Levels of EPHA4 and EFNB2 mRNA in the caudate, and EPHB2 mRNA in anterior cingulate were significantly lower in HIV+ subjects (p < 0.002, p < 0.02, p < 0.05, respectively). These transcripts also showed correlations with immune status and cognitive function within the HIV-infected group. Decreased levels of EFNB2 mRNA in the caudate correlated with lower CD4 counts (P < 0.05). Cognitive associations were limited to the cingulate, where decreased levels of EPHB2 mRNA were associated with better global cognitive status. Decreased cingulate expression of EPHB2 may represent a compensatory mechanism minimizing excitotoxic injury in the face of chronic inflammation.
关键词HIV dementia Human postmortem brain Ephrin receptors and ligands Chemokine receptors and ligands Neurocognitive impairment
学科领域Cognitive Neuroscience
URL查看原文
收录类别SCI
语种英语
项目资助者NIH [NIDA-P60-05130, NIMH-U01-MH083501]
项目简介This work was supported by NIH NIDA-P60-05130 (MJK), NIMH-U01-MH083501 (SM). We thank Allie Sperry for help in performance of RT-PCR assays, and the patients and staff of the Manhattan HIV Brain Bank. We acknowledge the help of Dr. Keiichi Niikura, Adam J. Brownstein, and Molly Deutsch-Feldman for the art work of the diagram.
WOS记录号WOS:000315441900031
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11512
专题中国科学院心理健康重点实验室
通讯作者Yuferov, V (reprint author), Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA.
推荐引用方式
GB/T 7714
Yuferov, Vadim,Ho, Ann,Morgello, Susan,et al. Expression of Ephrin Receptors and Ligands in Postmortem Brains of HIV-Infected Subjects With and Without Cognitive Impairment[J]. JOURNAL OF NEUROIMMUNE PHARMACOLOGY,2013,8(1):333-344.
APA Yuferov, Vadim.,Ho, Ann.,Morgello, Susan.,Yang, Yaning.,Ott, Jurg.,...&Yuferov, V .(2013).Expression of Ephrin Receptors and Ligands in Postmortem Brains of HIV-Infected Subjects With and Without Cognitive Impairment.JOURNAL OF NEUROIMMUNE PHARMACOLOGY,8(1),333-344.
MLA Yuferov, Vadim,et al."Expression of Ephrin Receptors and Ligands in Postmortem Brains of HIV-Infected Subjects With and Without Cognitive Impairment".JOURNAL OF NEUROIMMUNE PHARMACOLOGY 8.1(2013):333-344.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000315441900031.p(349KB) 开放获取Apache License请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yuferov, Vadim]的文章
[Ho, Ann]的文章
[Morgello, Susan]的文章
百度学术
百度学术中相似的文章
[Yuferov, Vadim]的文章
[Ho, Ann]的文章
[Morgello, Susan]的文章
必应学术
必应学术中相似的文章
[Yuferov, Vadim]的文章
[Ho, Ann]的文章
[Morgello, Susan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。